Often, after an infection has passed, a lymph node or group of nodes that reacted to the infection can remain enlarged for months (reactive adenopathy). While this is a normal process, reactive adenopathy needs to be differentiated from worrisome processes that also can affect lymph nodes.
Following infection, lymph nodes occasionally remain permanently enlarged, though they should be non-tender, small (less the 1 cm), have a rubbery consistency and none of the characteristics described above or below.
Swollen glands are more likely to be caused by cancer if they: don't go away within a few weeks and slowly get bigger. are painless and firm or hard when you touch them. occur with other symptoms, such as night sweats and weight loss.
Swollen glands are a sign the body is fighting an infection. They usually get better by themselves within 2 weeks.
But more often than not, minor infection or illness is the cause. They should go away as soon as your condition clears up. If you have swollen lymph nodes that don't go away or seem to grow over time, see your healthcare provider. You may have a more serious condition that needs proper diagnosis and treatment.
Sensitivity: Some people think cancer always hurts, but that's not true. Tenderness tends to be a sign of an infectious process, because the immune system has been challenged. But lymph nodes that are swollen due to lymphoma are usually not painful.
Swollen lymph nodes are often painless, moveable, and have a soft, “rubbery” feel to them, says Eric Jacobsen, MD, clinical director of the Adult Lymphoma Program at Dana-Farber.
Enlarged lymph nodes that have an irregular shape and a rubbery, hard consistency may be infiltrated by malignant cells.
Swollen lymph nodes usually occur as a result of infection from bacteria or viruses. Rarely, swollen lymph nodes are caused by cancer. Your lymph nodes, also called lymph glands, play a vital role in your body's ability to fight off infections.
Lymph nodes measuring more than 1 cm in the short axis diameter are considered malignant. However, the size threshold does vary with anatomic site and underlying tumour type; e.g. in rectal cancer, lymph nodes larger than 5 mm are regarded as pathological.
Often, after an infection has passed, a lymph node or group of nodes that reacted to the infection can remain enlarged for months (reactive adenopathy). While this is a normal process, reactive adenopathy needs to be differentiated from worrisome processes that also can affect lymph nodes.
Lymph nodes commonly swell if we have an infection but they usually go back to normal over a short time. With lymphoma, the lymph nodes often grow slowly and may be there for months or years before they're noticed. But sometimes they grow very quickly. Usually, the swollen nodes don't hurt.
While it may not be familiar, stress can certainly cause swollen lymph nodes. First, these small organs are located throughout the body.
Healthy lymph nodes are more rubbery than the surrounding tissue but are not solid like stone. Any lumps on the neck, groin or armpits that are hard, very enlarged, and do not move when pushed may indicate lymphoma or another type of cancer and should be investigated by your GP.
Blood Tests for Lymphoma
Blood tests are essential to accurately diagnosing this complex disease. These tests can show whether you have lymphoma cells or abnormal levels of normal cells: Blood smear: We take a drop of blood and look at it under a microscope.
For stage I NHL, the 5-year relative survival rate is more than 86%. For stage II the 5-year relative survival rate is 78%, and for stage III it is more than 72%. For stage IV NHL, the 5-year relative survival rate is almost 64%.
Most of the enlarged lymph nodes are not cancers. However, it is advisable to see a doctor when you find enlarged nodes that do not go away in 2 weeks, but no need to panic. Nodes that are rapidly increasing in size over weeks are a warning sign.
A lymphoma lump will tend to be painless and feel rubbery when touched. Swollen lymph nodes caused by other conditions like the flu can make your lymph nodes swell and feel tender when touched. A lymphoma lump also tends to be movable under the skin versus hard and unmovable.
Risk factors and associated cancers
Most cases of lymphadenopathy aren't caused by cancer. Malignancies are reported in as few as 1.1 percent of primary-care patients with swollen lymph nodes, according to a review in American Family Physician.
Unlike most cancers, rates of Hodgkin lymphoma are highest among teens and young adults (ages 15 to 39 years) and again among older adults (ages 75 years or older). White people are more likely than Black people to develop non-Hodgkin lymphoma, and men are more likely than women to develop lymphoma.
Lymphoma lumps have a rubbery feel and are usually painless. While some lymphoma lumps develop within a matter of days, others can take months or even years to become noticeable.
Lymph node status shows whether or not the lymph nodes in the underarm area (axillary lymph nodes) contain cancer: Lymph node-negative means none of the axillary lymph nodes contain cancer. Lymph node-positive means at least one axillary lymph node contains cancer.