1) Kaguya Otsutsuki As an Otsutsuki member, Kaguya is the strongest character in the Narutoverse.
While Naruto is an extremely strong character, there are a few that are capable of taking him down. Naruto Uzumaki is the Seventh Hokage of Konohagakure and the strongest shinobi to ever exist in the Naruto series, with Sasuke Uchiha being the only one close to him in terms of power.
Who are the gods in Naruto? Jashin is a god whose presence has little to no origins. He was first introduced by Hidan in Naruto Shippuden, and was the source of his immortality. According to Hidan, Jashin's ideologies center around violence and blood sacrifice.
Who is the god of Uchiha? Indra Otsutsuki is revealed to be the creator/ founder of the renowned Uchiha Clan in Naruto. He was the eldest son of Hagoromo Otsutsuki (The Sage of Six Paths) and the elder brother of Ashura Otsutsuki.
Jiraiya. Jiraiya was an exceptionally competent shinobi, and he was the only member of the Legendary Sannin who could actually beat Itachi. He was trained by the Third Hokage, and learned how to use Sage Mode while training with the toads of Mount Myoboku.
Sasuke is yet another strong character in the Naruto series who eventually surpassed Kakashi. Sasuke was so strong that he was able to perform jutsus like Indra's Arrow which has similar, if not the same destructive capabilities compared to Naruto's Six Paths: Ultra Big Ball Rasenshuriken.
Madara Uchiha is a legendary ninja with immense skill and chakra, and during the 4th Great Ninja War, he proved to be stronger than Sasuke. He possesses far more battle experience, and his Fire-Style ninjutsu was powerful enough to bathe an entire battlefield in fire.
He is dubbed by most to be the strongest shinobi in history. Sasuke himself admitted this fact. In the end, while Sasuke may not be able to beat Naruto, even with his perceived weakened state in Boruto, the two did become friends again. A combination of powers that are said to be able to destroy the entire world.
Sasuke was stated to be the strongest Uchiha to ever have been born, including Madara. So, obviously, his powers do exceed Madara's. With his Choku-tomou Rinnegan and Indra's arrow, he is almost invincible. As a result, he is also one of the Naruto characters who can defeat Madara.
Itachi Uchiha:
Itachi Uchiha is the single most powerful character in the Naruto Universe. Masashi Kishimoto named himself Itachi Uchiha. He unlocked his power at a very early age, for example, unlocking his Sharingan at a very early age.
1 Baryon Mode
Baryon Mode powered Naruto Uzumaki up to great levels, and made him strong enough to overpower Isshiki Otsutsuki in battle. This transformation made him the strongest character in the story, and is Naruto's strongest form by far.
Kakashi's own double Mangekyo Sharingan power is far superior to Guy's eight gates. Even though Guy almost touches the speed of light, Kakashi's Kamui is instantaneous. He's fast enough to blitz even Kaguya Otsutsuki, and as such, Might Guy stands no chance.
Naruto and Sasuke are arguably the most powerful characters by the end of the Naruto Shippuden anime, so it goes without saying that Might Guy would stand no chance against Naruto in his Sage of Six Paths mode, or against Sasuke using his Rinnegan.
In conclusion, Obito Uchiha would defeat Itachi Uchiha when comparing the two characters in their strongest forms. Obito has one of the strongest, if not the strongest, Sage Mode in the series and has enough chakra reserve to beat Itachi.
Hashirama Senju
This one is a pretty obvious choice, but it's worth restating. The legendary First Hokage, Hashirama Senju was known as the "God of Shinobi" for a reason. He was the only one capable of defeating Madara Uchiha during the latter's early life.
Sasuke would have only won by outlasting Itachi, and if the latter had no reason to hold back then he would have gone all-out. When the two brothers fought against Kabuto, it was only because of Itachi's knowledge that they managed to defeat him.
6 Shin Uchiha
He was one of Orochimaru's experiments that ultimately went rogue. Shin was given several Sharingan Eyes (much like Danzo) and even managed to awaken his Mangekyou. He had plans to resurrect the Akatsuki and was confronted by Naruto Uzumaki and Sasuke Uchiha in Boruto.
Obito Uchiha was one of the strongest Uchiha to ever exist. He awakened his Mangekyō Sharingan during the Third Great Ninja War after witnessing Rin die. Obito's eye weilded the Kamui, a powerful space-time ninjutsu.
Sasuke Uchiha
As you should understand by now, Sasuke Uchiha is the most handsome male character in Boruto: Naruto Next Generations.