Acetaminophen or Tylenol® is the best known medication that can damage the liver. This medication is widely available without prescription and is present in many of the cold and flu remedies as well as in prescribed pain medications.
Acetaminophen is harder on the liver than ibuprofen. The liver is the main organ responsible for breaking down acetaminophen. When taken occasionally, and at recommended doses (no more than 4,000 mg per day), it shouldn't cause any liver damage.
Acetaminophen (paracetamol), when taken in reduced doses (maximum 2–3 grams per day), is generally considered to be the safest pain relief option for your liver.
Abuse of paracetamol can cause damage on your liver, while abuse of ibuprofen can cause damage to your stomach or liver. It's safer to take paracetamol if you are pregnant than ibuprofen. (In the case of the latter, you should consult your doctor first, but completely avoid it in your 3rd trimester)
Nonprescription pain relievers such as acetaminophen (Tylenol, others), aspirin, ibuprofen (Advil, Motrin IB, others) and naproxen (Aleve, others) can damage your liver, especially if taken frequently or combined with alcohol.
Ibuprofen has the highest liver safety profile among NSAIDs and showed no severe liver injury in larger studies. Along with paracetamol and aspirin, it is considered one of the most common over the counter NSAIDs sold in the world.
Taking 1 or 2 extra tablets is unlikely to harm you. Do not take more than 8 tablets in 24 hours. Taking too much paracetamol can be dangerous and you may need treatment.
3) Diclofenac (Voltaren, Cambia)
Any NSAID (non-steroidal anti-inflammatory drug) can cause liver injury, although it's very rare. This class of medications includes popular drugs like ibuprofen and naproxen. But when it comes to liver injury, diclofenac is the NSAID with the highest risk.
Scientists at the University of Edinburgh studied the impact of paracetamol on liver cells in human and mouse tissue, and tests showed that in certain settings paracetamol can damage the liver by harming vital structural connections between adjacent cells in the organ.
Acetaminophen remains the drug of choice for occasional use in patients with kidney disease because of bleeding complications that may occur when these patients use aspirin.
Acetaminophen. Taking acetaminophen in excess is the leading cause of drug-induced liver injury.
Foods that support liver health include berries, cruciferous vegetables, beans, whole grains, nuts, and fatty fish. Coffee and green tea contain antioxidants that are helpful for liver health.
It's safe to take ibuprofen with paracetamol or codeine. But do not take ibuprofen with similar painkillers like aspirin or naproxen without talking to a pharmacist or doctor.
Naproxen. Another anti-inflammatory drug, which works much like ibuprofen. Some studies show this may be a better choice than ibuprofen for people at risk for heart disease. Aspirin.
Side effects of paracetamol
blood disorders, such as thrombocytopenia (low number of platelet cells) and leukopenia (low number of white blood cells) liver and kidney damage, if you take too much (overdose) – this can be fatal in severe cases.
Non-steroidal anti-inflammatory drugs, or NSAIDs, like ibuprofen rarely affects the liver. Most users have little risk of liver damage from ibuprofen medication.
Older adults may be at greater risk for stomach/intestinal bleeding, kidney problems, heart attack, and stroke while using this drug. Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks.
The maximum daily dose of 4 g in any given 24 hour period should not be exceeded as well. Paracetamol is generally a safe, non-prescription pain reliever, but misuse and overdose do occur. This is because so many medications contain paracetamol that it's easy to take too much of the drug without realizing it.
Do not use for more than a few days at a time unless your doctor tells you to. Do not take more than the recommended dose unless your doctor tells you to. Do not use PANADOL OSTEO to treat any other complaints unless your pharmacist or doctor tells you to.
In general, acetaminophen (the active ingredient contained in Panadol Osteo) is well-tolerated when administered in therapeutic doses. The most commonly reported adverse reactions have included nausea, vomiting, constipation. Injection site pain and injection site reaction have been reported with the IV product.