The safety studies for NexGard had a good outcome with a very small percentage of dogs experiencing minor adverse effects. The most frequently reported adverse reaction was vomiting; less frequent reactions included dry skin, diarrhea, lethargy, and anorexia.
I would not expect the lethargy or diarrhea to last more than 12-24 hours.
The only downside to NexGard is that the parasites have to bite the dog to be affected by the medication, which can sometimes take several hours to take place. We'll contact your Vet to verify.
What are the risks associated with Nexgard Spectra? The most common side effects (affecting inbetween 1 to 10 animals in 1,000 animals) were vomiting, diarrhoea, lack of energy, decreased appetite, and itching, which generally were short-lived and resolved spontaneously.
NexGard (afoxolaner) is for use in dogs only. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite.
Simparica Trio works against the same ticks and fleas as Nexgard and also protects your dog from heartworms, hookworms, and roundworms.
If chemical products are necessary for additional flea or tick control, NRDC recommends s-methoprene or pyriproxyfen, which are less toxic ingredients—but read the labels carefully because some products use them with other, more harmful pesticides.
“NexGard (afoxolaner) is one of the isoxazoline class of parasiticides. Please do NOT use any of them again. There are now two isoxazoline-related class-action lawsuits in North America — one in Quebec and the other in New Jersey. The FDA finally has required warnings on the labels and product inserts.
NexGard® Recalls & Controversies
Although there have not been any FDA recalls for NexGuard®, the FDA has put out an alert for pet owners and veterinarians. This is because there is potential for neurological adverse events in dogs and cats when they are treated with drugs that fall into the isoxazoline class.
A Pesticide That Targets the Central Nervous System
Isoxazolines are neurotoxic to more than just insects; they also affect mammals. There is a reason why so many dogs experience seizures, ataxia, and tremors after taking NexGard — the pesticide compromises the dog's central nervous system.
NEXGARD® is recommended for use in dogs and puppies 8 weeks of age and older. FOR ANIMAL USE ONLY. NEXGARD® contains afoxolaner, an insecticide-acaricide for oral treatment and prevention of flea and tick infestations of dogs for one month following a single administration.
NexGard is given as a tablet of the appropriate strength for the dog's bodyweight. NexGard kills fleas within 8 hours and ticks within 48 hours. After being given, its actions last for at least 5 weeks against fleas and up to one month against ticks.
NexGard works quickly, entering the bloodstream within 30 minutes of ingestion. It starts killing fleas within 4 hours and ticks within 12 hours. One study found that afoxolaner kills existing fleas within 2 to 6 hours and maintains an average mortality rate of between 97.6% to 100% for 3 weeks after treatment.
Nexgard can kill 99% of all infections in a single treatment. The product kills eggs, larvae, and full-grown parasites making it highly effective in protecting your dog's health.
If after 24 hours your pet still continues to scratch, there could be other things going on. Your pet could be flea-allergic, it could have a skin infection or a hormone imbalance, or other conditions which can lead to itchiness.
Yes, Nexgard is an incredibly safe and effective prevention for fleas, ticks, and mites. However, because Nexgard is ingested and absorbed into the bloodstream, rather than applied to and spread by the oils of the skin, the few reactions that do occur can seem more dramatic.
As you can see, both Nexgard and Simparica are extremely good and effective flea and tick treatment and they do not have a major difference between them. But that being said, Simparica does kill an additional tick specie and is relatively faster in eliminating fleas and ticks.
Both contain the active ingredient afoxolaner, providing excellent protection against fleas, ticks and mites. NexGard SPECTRA contains an additional active ingredient, milbemycin oxime, which provides protection against heartworm and intestinal worms.
The most common signs of toxicity from pyrethrum-based flea products are muscle tremors and excessive salivation. Common signs of toxicity from flea products containing organophosphates are diarrhea, vomiting, difficulty breathing, small pupils, muscle tremor, weakness or falling over, and drooling.
The answer is yes, flea and tick preventatives need to be applied year-round in order to keep your pets safe. Read on to learn more about how fleas and ticks operate, the dangers they can harbor, and how best to protect your dogs and cats.
Nexgard will protect your dog from heartworm, so if you live in an area with a low risk of heartworm, Nexgard may be all your dog needs. However, if you use Nexgard and Heartgard at the same time, your dog will be protected from most types of parasites, including heartworm, fleas, and ticks.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. However, unlike Bravecto, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
The major difference between these two is the accessibility. Frontline Plus is available over the counter while Nexgard requires a prescription. With that said, the results of Nexgard are faster acting with a 24 hour turn around for ticks and four hours for fleas, giving your pet faster relief.