It's said by many that
The fact that Goku could not defeat Jiren with Super Saiyan Blue combined with the Kaioken technique, but was later able to defeat him using Ultra Instinct proves that Ultra Instinct is vastly more powerful.
Hercules is the Olympian God of Strength, and he might be one of the unique ones on this list capable enough of matching and overpowering Ultra Instinct Goku in terms of pure strength. Being a Half-God, Hercules is nigh-omnipotent and invulnerable to almost anything.
Ultra Instinct is at least 20x stronger than Super Saiyan Blue considering that Super Saiyan Blue Goku Kaioken x20 was a joke against Jiren, yet Ultra Instinct Goku actually pushed him back and proved a challenge.
Pointing it out here, Gogeta would win, not because of his strength, but rather because of UI Goku's Time Limit, though UI Goku is stronger.
Jiren was able to fight against Mastered Ultra Instinct Goku during the Tournament of Power, and he even held his own against him, meaning he should be able to do the same against Gogeta. Furthermore, Jiren got gradually stronger as the two fought and it's possible for him to do the same against Gogeta as well.
Gogeta technically did beat Broly in the climactic final battle of Dragon Ball Super: Broly , but Broly obviously wasn't killed.
A final and most likely scenario is that there's simply nothing after Ultra Instinct. Goku will eventually learn Autonomous Ultra Instinct, and this will be his most powerful form through the rest of Dragon Ball.
By using his Ultra Instinct -Sign- form, Goku achieved True Ultra Instinct, which affords him the benefits of Ultra Instinct along with the willpower gained through his Saiyan emotions and is Goku's strongest form to date.
Deus ex machina is the most powerful character in Future Diary. He is known as the ruler of Time and Space. His control over these domains allows him to create the Future Diaries. Due to his ability to warp reality, he can defeat Ultra Instinct Goku as easily as Featherine.
Ultra Instinct can only be activated at the brink of death. Ultra Instinct drains an insane amount of stamina and energy.
Literally referred to as the "State of the Gods," it would be no surprise if Ultra Instinct Goku could already beat Beerus. As the main character, Goku eventually surpassing Beerus is all but guaranteed.
Super Saiyan 3 Goku at full power has a battle power of 24,000,000,000, 2 billion above Kid Buu's level.
The largest drawback of Ultra Instinct is the difficulty in which the technique is to master. For instance, the Hakaishin Beerus spent millions of years in training and still has not mastered the technique. A significant part of this difficulty comes with the technique's massive stamina drain.
It's said by many that Super Saiyan Blue Evolution is not as strong as Ultra Instinct. That it is only as strong as Super Saiyan Blue Kaioken X20.
Before long, however, Goku unwittingly unlocked Ultra Instinct while fighting Jiren during the Tournament of Power–and since then, he's been able to tap into it a few more times.
It all depends on the situation. The first time that Goku achieved Perfected Ultra Instinct, it was out of desperation to defend his universe from extinction; this second time he achieved it to honor the sacrifice of his friend and mentor, the angel Merus.
In summation. Through the use of dragon balls, it is indeed possible for a human to achieve Ultra Instinct. Although only two wishes are needed for this to be possible, a third would certainly improve the chances.
Goku may never pass Zeno and 4 other Dragon Ball characters
While his fight with Moro showed he can beat another Ultra Instinct user, Whis' Angelic heritage and proficiency is unfathomable.
Does that mean now that Goku has finally awakened the powers of the True Ultra Instinct, it just might be his ticket to defeating Beerus? Unfortunately, the answer is no.
1) Beerus. Although Jiren is said to be able to defeat a God of Destruction, it's unlikely Beerus is at risk of suffering that defeat. Beerus has yet to use 100% of his powers in Dragon Ball Super thus far, whereas Jiren at 100% struggled against Mastered Ultra Instinct (MUI) Goku.
Whis is one of the strongest beings in existence, and interestingly enough, only his father and the Omni King are confirmed to be stronger than him.
Beerus has said that Whis is stronger than him, and Whis once demonstrated this by knocking Beerus out with a single blow to the neck.