It takes at least 7 days after a dose to get the full benefit of this drug. The dose may need to be repeated depending on your blood calcium levels. For the treatment of multiple myeloma and bone problems caused by the spread of cancer, this medication is usually given every 3 to 4 weeks or as directed by your doctor.
Zoledronic acid can cause flu-like symptoms such as joint and muscle pain, fatigue, shivering and fever. These can last for a few days. Your treatment team can advise you about taking mild pain relief to help.
Zoledronate (zoledronic acid) Zoledronate is a drug treatment for osteoporosis. It can help to strengthen bones, making them less likely to break. It is given as an intravenous infusion (IV or 'drip') once a year.
Zoledronic acid is one of the bisphosphonate drug treatments which are used to reduce the risk of broken bones in people with osteoporosis. It is given as an intravenous infusion (drip), 5mg once a year, usually in a hospital clinic. The drug is given slowly, typically over 20 minutes via a needle inserted into a vein.
Zoledronic acid medication is a long-acting drug. As such, it stays in your body longer than 12 months (probably more than 24 months). Therefore, delaying your treatment for a number of months will not put you at a higher risk of sustaining fragility fracture nor cause significant decline in your bone mineral density.
Both treatment groups lost body weight during the study (placebo 1.65 kg, zoledronate 1.05 kg), and this was significantly greater in the placebo group (P = 0.01). Both groups lost lean mass, and this loss was marginally (0.17 kg) but significantly (P = 0.02) greater in those receiving zoledronate.
Medicare recipients who are prescribed zoledronic acid as an outpatient treatment, Medicare Part B may cover some of the cost of your care and medication. There may be a copay or coinsurance amount that applies, as well as a deductible amount that must be met before costs are covered by Medicare.
According to a list of zoledronic acid side-effects, dangerous side-effects such as coma, confusion, convulsions, difficult breathing, hypotension, atrial fibrillation, and cardiac arrhythmia secondary to hypocalcemia are possible [16].
If you are having zoledronic acid to help prevent the cancer coming back, you will have an infusion once every 6 months for 3 to 5 years. If you are having zoledronic acid to lower calcium levels in your blood, it is usually given as a single dose.
Tell your doctor if you have serious side effects of Reclast including urinating less than usual or not at all; drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting, swelling, weight gain, shortness of breath, muscle spasms, numbness or tingling (especially around your mouth), ...
Zoledronic acid (Zometa) is not cancer chemotherapy, and it will not slow or stop the spread of cancer.
The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of zoledronic acid. pregnancy. It is best to use birth control while being treated with zoledronic acid. Tell your doctor right away if you or your partner becomes pregnant.
3.5. Effects of ZOL on anti-cancer immunity. In addition to its effects on bone cells, ZOL has profound effects on the immune system, including a plethora of immune cell subsets expressing the mevalonate pathway enzymes, leading to a general increase in anti-tumour immunity [65].
Some people report insomnia, anxiety or confusion, coughing, and skeletal pain with zoledronic acid.
Recheck calcium level weekly as long as risk of hypercalcaemia remains or more frequently if symptoms dictate. 10. Give further doses of bisphosphonate (zoledronic acid) if calcium levels high and it is more than 3 weeks since the last dose of bisphosphonate.
EFFECTIVENESS. Zoledronic acid has been shown to decrease spine and hip fractures in two studies. It has been studied in women with a mean age of 73 years who are at high risk of fracture (three-year risk of any fracture of 12.8 percent).
User Reviews for Zoledronic acid to treat Osteoporosis. Zoledronic acid has an average rating of 4.7 out of 10 from a total of 221 reviews for the treatment of Osteoporosis. 32% of reviewers reported a positive experience, while 48% reported a negative experience.
Zoledronic acid (Aclasta) is given as a once-yearly injection. bisphosphonate treatments that are taken orally as once-daily or once- weekly tablets. with osteoporosis has shown that zoledronic acid (Aclasta) is effective in reducing the risk of hip, spine and other fractures.
Zoledronic Acid Injection 4mg, Packaging Type: Box, Packaging Size: 1 Vial at Rs 2990/piece in Mumbai.
If you are having dental procedures while receiving this medicine, you may have an increased chance of having a severe problem with your jaw. Make sure you tell your doctor or dentist about any new problems, such as pain or swelling, with your teeth or jaw.
Zoledronic acid is associated with a 25% increased risk of atrial fibrillation during its first year of use for osteoporosis compared to treatment with denosumab, shows a US study published in Journal of Bone and Mineral Research.
Musculoskeletal side effects following intravenous zolendronic acid, have also been reported, including the onset of new arthritis, painful joints and flare of existing osteoarthritis (11, 18, 24).