Simparica Trio is highly effective for heartworm prevention, demonstrating 100% efficacy in FDA-approved studies when administered monthly as directed. It is a reliable, all-in-one preventative that has also shown strong results against some macrocyclic lactone-resistant heartworm strains.
Simparica Trio prevented microfilaremia in all dogs and was highly effective (97.2%) and significantly better than either Heartgard Plus (8.5%) or Interceptor Plus (35.9%) in preventing the development of the ZoeLA ML-resistant heartworm strain when administered for six consecutive months in this comparative laboratory ...
Choose Simparica Trio if your dog needs broad-spectrum protection—especially if fleas and ticks are a concern. Opt for Heartgard Plus if your dog is young, pregnant, lactating, or mainly indoors and you want targeted protection against heartworms and intestinal worms.
It is recommended that your dog is given an additional allwormer every 3 months (monthly for dogs 12 weeks – 6 months) for treatment against the less common Whipworm and Tapeworm. This is now included in the Total Wellness Plan at no additional charge.
In a separate well-controlled laboratory study, SIMPARICA TRIO demonstrated 100% effectiveness against adult fleas within 24 hours following treatment and maintained ≥99.7% effectiveness against weekly re-infestations for 35 days.
What will my veterinarian recommend for flea and tick treatment? Veterinarians may recommend Simparica Trio, a monthly chewable tablet that prevents against heartworm, fleas, ticks, and intestinal parasites. Revolution Plus and Bravecto are also commonly recommended treatments.
Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.
Simparica Trio™ has not been evaluated in dogs that are pregnant, breeding or lactating. Simparica Trio™ has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications. Use with caution in dogs with a history of seizures.
Simparica Trio Chewable Tablet for Dogs is our vets' pick for the best flea, tick, and heartworm prevention for dogs.
We recommend Drontal Allwormer, Paragard or Endogard dog worming tablets. Puppies should be wormed every 2 weeks until 12 weeks old and then once a month until 6 months. From 6 months old a regular 3 monthly deworming program should remain.
Simparica kills both fleas and ticks, while Frontline Plus is effective against fleas, ticks, flea eggs and larvae and lice. Simparica kills fleas within 3 hours and kills ticks within 8 hours. Frontline Plus kills fleas within 12 hours and ticks within 48.
However, Heartgard Plus Chewables cannot prevent the development of the adult stage. Use with caution for collies and other herding dog breeds. These breeds have been known to have adverse reactions to ivermectin at elevated dose levels.
Simparica trio for dogs side effects: may cause neurological signs such as tremors, instability, and seizures in dogs with or without a history of neurological disorders.
It is also imperative to have your pet tested yearly for heartworms while on preventative. Heartworm preventatives are highly effective, but dogs can still become infected. If you miss just one dose of your monthly medication – or give it late – it can leave your dog unprotected.
The best prescription alternatives to Simparica Trio include NexGard PLUS, Interceptor Plus with Bravecto or NexGard, and Credelio Quattro. These are made by trusted veterinary pharmaceutical companies like Boehringer Ingelheim, Elanco, Zoetis, and Virbac.
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Although there are fewer mosquitoes in the winter, there is still a risk that your pet could get heartworms if you stop giving heartworm prevention medication during this season. That's one reason veterinarians strongly recommend pets receive heartworm prevention medication year-round.
Monthly Simparica Trio prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and hookworm infections in dogs and puppies 8 weeks of age and older, and weighing 2.8 ...
Heartworm Prevention: SIMPARICA TRIO should be administered at monthly intervals year-round or at least within one month of the animal's first seasonal exposure to mosquitoes and continuing until at least 1 month after the dog's last seasonal exposure.
It's not uncommon for pets to experience mild side effects after taking medication like Simparica Trio. Lethargy can occur, but it's crucial to watch for any severe reactions such as vomiting or seizures. If your dog's lethargy continues or they show signs of distress, contacting your vet is the best course of action.
Popular, vet-recommended flea and tick medicines for dogs include chewables Simparica and Credelio, plus Bravecto topical, all of which are prescription medicines. Your vet can help you choose the best flea and tick medication for your individual dog based on their specific needs.
Use NexGard PLUS with caution in dogs with a history of seizures or neurologic disorders. For more information, click here for full prescribing information. Following the use of HEARTGARD Plus (ivermectin/pyrantel) in dogs, digestive and neurologic side effects and itching have been reported.
If you're hoping to find a broad-spectrum product that protects against fleas and ticks while it defends against internal parasites, Simparica Trio is the clear winner. However, if your dog is already taking a flea and tick preventative, your vet clinic might suggest concomitant use of Heartgard Plus.