Lithium has been associated with impaired memory, word finding difficulties, and impaired recall. Often, my patients have reported a cognitive "dulling" and a loss of cognitive "creativity" with lithium use that they found most disturbing.
A common complaint made by those who take lithium, but one which may easily be overlooked, is cognitive compromise. Clinically, patients describe this as “brain fog”-an elusive admixture of complaints regarding attention, concentration, and memory occurring in conjunction with a slowing of thought processes.
Long-term lithium use may cause cortical atrophy and cognitive dysfunctions. Patients who use lithium should be monitored with brain MRI.
The most common side effects of lithium are feeling or being sick, diarrhoea, a dry mouth and a metallic taste in the mouth. Your doctor will carry out regular blood tests to check how much lithium is in your blood.
Lithium has been shown to delay the progression of Alzheimer's disease to reduce the prevalence of dementia.
Adverse effects were the most common cause for lithium discontinuation. Among the adverse effects, diarrhoea, tremor, creatinine increase, polyuria/polydipsia/diabetes insipidus and weight gain were the top five reasons for discontinuing lithium.
Lithium has been reported to be beneficial in animal models of brain injury, stroke, Alzheimer's, Huntington's, and Parkinson's diseases, amyotrophic lateral sclerosis (ALS), spinal cord injury, and other conditions.
Lithium may cause problems with kidney health. Kidney damage due to lithium may include acute (sudden) or chronic (long-term) kidney disease and kidney cysts.
The reputation that lithium got for being "toxic," "mind numbing," and so forth, certainly those things have an element of truth to them. But they come from earlier studies where people were kept at a much higher doses and blood levels of lithium.
Although lithium has been used in significantly longer-term treatment than any other mood stabilizer, long-term therapy is not devoid of adverse effects, the most important of which is kidney damage.
We assessed the association between lithium use and the incidence of dementia and its subtypes, including Alzheimer disease (AD) and vascular dementia (VD). We found that lithium was associated with a lower risk of receiving a diagnosis of dementia, including a lower risk of being diagnosed with either AD or VD.
Memory loss is a frustrating and overwhelming challenge for as many as 40 to 60 percent of people with bipolar disorder. That's according to a research article published in the August 2017 International Journal of Neuropsychopharmacology .
Lethargy, dysphoria, a loss of interest in interacting with others and the environment, and a state of increased mental confusion were reported. No generalized effects were found in the responses to the personality inventories. 1. 2.
The syndrome of irreversible lithium effectuated neurotoxicity (SILENT) is characterized by cerebellar dysfunction, extrapyramidal symptoms, brainstem dysfunction, and dementia. Other symptoms can include nystagmus, choreoathetoid movements, myopathy, and blindness.
The most common thyroid side effects associated with long-term lithium treatment are hypothyroidism and goiter. The prevalence of hypothyroidism during lithium treatment varies from 6% to 50%, with significantly higher female preponderance.
Chronic lithium has been shown to enhance spatial working memory and to promote long-term retention of a weak aversive contingency (Tsaltas et al. 2007a, b). It has also been shown to promote learning in three different spatial cognitive tasks involving positive reinforcement (Nocjar et al. 2007).
These side effects include: use of large quantities of water and related pollution; potential increase in carbon dioxide emissions; production of large quantities of mineral waste; increased respiratory problems; alteration of the hydrological cycle. Obviously the economic interests at stake are enormous.
Of 873 patients treated with lithium, 54% discontinued lithium, corresponding to 561 episodes of lithium discontinuation. In 62% of episodes, lithium was discontinued due to adverse effects, in 44% due to psychiatric reasons, and in 12% due to physical reasons interfering with lithium treatment.
Despite its overall advantages, lithium-ion has its drawbacks. It is fragile and requires a protection circuit to maintain safe operation. Built into each pack, the protection circuit limits the peak voltage of each cell during charge and prevents the cell voltage from dropping too low on discharge.
One of the side effects of lithium maintenance therapy is weight gain. Scientists believe that lithium-associated weight gain occurs due to various reasons, such as increased thirst, increased appetite, alterations in metabolism, sodium retention, hormonal fluctuations, constipation, and fatigue.
Approximately 25% of people gain weight from taking lithium, according to a review article published in Acta Psychiatrica Scandinavica. 1 After analyzing all relevant published medical studies, the authors reported an average weight gain of 10 to 26 pounds among those who experience this troubling side effect.
The ones that treat bipolar depression are cariprazine (Vraylar), lurasidone (Latuda), olanzapine-fluoxetine combo (Symbyax), and quetiapine (Seroquel). Among them, lurasidone offers a good balance of efficacy and tolerability.
Not suitable for people with significant renal or cardiovascular disease, who are frail, dehydrated, taking diuretics, with low levels of sodium, or on a sodium-restricted diet. In exceptional circumstances, lithium may be used if the patient's condition is life-threatening and other treatments have failed.
Lithium is not recommended in patients with renal impairment. It is also not recommended in patients with cardiovascular disease. Lithium causes reversible T wave changes and can unmask Brugada syndrome. A cardiology consult is necessary if a patient experiences unexplained palpitations and syncope.
Some side effects are common when people first start lithium, such as: Tremors (shakiness), especially in the hands. Dry mouth. Feeling thirstier.