Jamie has a son named William Ransom with Geneva Dunsany, who died during William's birth. Jamie also has two stepdaughters, Marsali MacKimmie Fraser and Joan MacKimmie, from his marriage to his second wife, Laoghaire MacKenzie.
Claire and Jamie only have two biological children together: Faith and Brianna. Faith was the stillborn baby in France. Mother Hildegarde baptized the child despite it being against the law, and Jamie never got to see her. He was in the Bastille at the time, and Claire almost died of childbed fever.
Murtagh is godfather to Jamie Fraser, the son of his second cousin, Brian Fraser.
“He's about 25,” Gabaldon said. It's an interesting response. If you're up to date on the series, then you know that Jamie is not dead at the age of 25.
The simple answer is no. Claire and Jamie don't have any more children after Brianna. Claire heads through the stones while pregnant with Brianna at the end of the second season/book. She spends 20 years in the 20th century, and she and Frank don't have any children together.
Unable to sleep, Claire heads to Colum's library to borrow a book, and ends up eavesdropping on a conversation between Colum and Dougal. She discerns that Dougal has gotten Laoghaire pregnant.
William loses both his mother Geneva, who dies during childbirth, and his supposed father the Earl (killed by Jamie), shortly after his birth, from there he ends up in the care of Jamie's friend and close confidant Lord John Gray - who had married Geneva's sister Isobel.
Murtagh is surely aware of Jamie's captivation for Claire; he is also likely conscious of Claire's reciprocation. Murtagh desires the best for Jamie. He does not wish for Jamie to just marry anyone.
Season 4, Episode 9 “The Birds and The Bees” – Part 1
This is without a doubt, the best Jamie dad moment in the series — the moment he meets his and Claire's daughter, Brianna. It's one of those scenes that even if your heart is made of ice, it will melt. And you will cry. Go on watch it, try not to cry.
Claire tells the entire family her true identity of being a time-traveller from the future, but Jenny still views her as a 'witch' or 'faery-woman'.
Claire realises that she had fled because she was afraid that Jamie wouldn't choose her, but she now knows that her future is with Jamie and she will stay. Jamie awakens but thinks that Claire is part of a fever dream until she touches him and he realises she is real.
Unbeknownst to Willie, his birth father was not the elderly Earl of Ellesmere at all, but Jamie Fraser.
During his time apart from Claire, Jamie slept with several women, including Mary McNab (Emma Campbell-Jones) and Geneva Dunsany (Hannah James). And of course, there was Laoghaire MacKenzie (Nell Hudson) as well who had her sights on Jamie since season one.
Claire asks Lord John if he believes she (and Brianna and Roger) are from the future, to which he says that he doesn't, but that he will behave for all appearances as though he does.
Claire gives him a beautiful, tender answer: she shares his regret, but regret is not enough. And together they make the decision to give the baby to Lucinda, a young mother who lost her own baby at birth, and has both love and milk in abundance.
Grey falls in love with Jamie, who rejects his advances. Still, Grey cannot dismiss his feelings.
Despite being nephew and uncle, Jamie and Dougal had a complex relationship with the clan chieftain viewing his nephew as a rival and wanting to dominate the young man, including marrying Claire.
Jamie: "Claire, it was you. It's always been you, and it always will be. Get into bed and put the candle out.
While on a second honeymoon in Scotland with her husband, Frank Randall, Claire inadvertently travels two hundred years into the past, where she meets and eventually marries Jamie Fraser.
During An Echo in the Bone/Written in My Own Heart's Blood, Claire marries for the third time. This time it's to Lord John Grey.
Roger is the father of Bree's baby in Outlander
The Outlander Season 6 finale included the lice scene. It wasn't quite the same way as the books, but it was still a great way to make it clear that Jemmy and Roger are related by blood.
Events of the Novels
Claire and Jamie care for her and give her goat's milk, keeping her warm as they bring her into Brownsville. Once in Brownsville, they find a nursing mother to feed the child, and Richard Brown makes the executive decision to take her in and raise her as his.