Fat-soluble and water-soluble vitamins For example, although it's safe to take vitamin D with vitamin B12, it's not advisable, says Virgilio Sanchez, MD, a board certified family medicine physician at Conviva Care Center in Miami, Florida.
“Take water-soluble vitamins on an empty stomach with a glass of water,” recommends Dr. Perez-Gallardo. And since it can be energizing, Dr. Perez-Gallardo says that the best time to take vitamin B12 is in the morning, so it won't affect your sleep.
Vitamin C (ascorbic acid) supplements.
Taking vitamin B-12 with vitamin C might reduce the available amount of vitamin B-12 in your body. To avoid this interaction, take vitamin C two or more hours after taking a vitamin B-12 supplement.
According to health experts at Click Pharmacy, as a general rule of thumb, take your B vitamins in the morning or with a meal. Vitamin B12, for example, should definitely be taken in the morning. This is because it is important for energy metabolism, which may interrupt your sleep if taken at night.
Your body needs C, D3, and B12 for essential functions that include immune defense, bone maintenance, and energy metabolism. * No matter what your supplement regimen is, getting reliable sources of these nutrients every day helps to nourish your body WELL.
CALCIUM+VITAMIN B12+VITAMIN D3 is likely safe to consume. In some cases, it may cause side effects like diarrhoea, constipation, and stomach upset. These side effects do not require medical attention and gradually resolve over time. Do not take CALCIUM+VITAMIN B12+VITAMIN D3 if you're allergic to any ingredient in it.
Vitamin B12 is essential for energy. If you don't get enough of it, you can feel fatigued, weak, and generally run down. Eating B12-rich foods, oral supplements, and B12 injections can all raise your levels back to the normal range.
Vitamin D and sleep: The surprising connection
Early research suggests it is inversely related to melatonin, your sleep hormone. Increasing vitamin D levels may suppress melatonin levels. So, it makes sense that taking it at night could disrupt your sleep.
There's no set time of day that's best to take vitamin D supplements. Some people say taking vitamin D supplements at night is an insomnia risk. There's no research to confirm this, but you might want to take your supplement earlier in the day if you think it's screwing with your sleep.
There's been some buzz suggesting a link between supplementing with vitamin D before bedtime and the ability to drift off to dreamland. Some studies have shown that vitamin D is connected to the production of melatonin, which regulates circadian rhythm and drives sleep.
As summarized in the table provided, vitamin B12 (cobalamin) absorption and utilization by the body can be compromised with the chronic use of certain medications which include: colchicine, chloramphenicol, ethanol, histamine 2 receptor antagonists (H2RA), metformin, and proton pump inhibitors (PPI).
Therefore, conditions that affect the gut and digestion, like celiac disease, chronic pancreatitis, Crohn's disease, and cystic fibrosis, can reduce vitamin D absorption.
Vitamins D, E and K
“Studies have shown that a person's absorption of Vitamin K may be reduced when other fat-soluble vitamins such as Vitamin E and Vitamin D are taken together,” says Dr. Chris Airey, M.D. “It's advised that you take these vitamins at least 2 hours apart to maximize your absorption.”
The best time to take fat-soluble vitamins like vitamin D, A, and K is with a meal containing fats. You should take water-soluble vitamins like vitamin C, B12, and B6 in the morning on an empty stomach. Take multivitamins or prenatal vitamins with a meal or snack containing fat and a glass of water.
It's usually best to take the tablets on an empty stomach. This means at least 2 hours after a meal or snack and at least 30 minutes before you eat again.
Those with the lowest levels should feel an improvement after just a few days, while those who only need to top up their levels may have to wait a week or two before they begin to feel healthier and more energised.
"Adequate levels of magnesium in the body are essential for the absorption and metabolism not only of vitamin D but of calcium as well," Dean states. "Magnesium converts vitamin D into its active form so that it can help calcium absorption.
Supplementing vitamin B6 may improve sleep quality and duration. A 2019 study also found that taking a supplement of magnesium, melatonin, and vitamin B complex for 3 months improved sleep and helped treat insomnia.
Use vitamin D cautiously if you're taking drugs processed by these enzymes. Digoxin (Lanoxin). Avoid taking high doses of vitamin D with this heart medication. High doses of vitamin D can cause hypercalcemia, which increases the risk of fatal heart problems with digoxin.
There are quite a few differences between vitamin D and vitamin D3, but the main difference between them is that vitamin D is a fat-soluble vitamin that regulates calcium and phosphorous levels in the body, whereas the vitamin D3 is the natural form of vitamin D produced by the body from sunlight.
More Serious Effects
B12 injections may contribute to low potassium levels in your body. Though rare, this reaction can cause muscle cramping, extreme fatigue, and an irregular heartbeat.
Thus if you're otherwise healthy but still continue to feel tired after taking a B-12 supplement, it could be a sign of a mild allergic reaction. If a rash, difficulty breathing or swelling coincides with taking your dose of B-12, get to the doctor right away.
Symptoms of vitamin D deficiency may include:
Fatigue. Not sleeping well. Bone pain or achiness. Depression or feelings of sadness.