You Will Regain Weight Because people stop feeling full and their food cravings return when they stop Ozempic, weight gain is likely, Kushner says.
Some individuals may actually gain more weight after stopping an obesity drug than they initially lost, Conde-Knape added. Studies have similarly shown weight rebound in people who stop taking Ozempic.
As soon as someone stops taking the drug, their body fat and former appetite tend to return. Experts recommend working with a provider versed in obesity medicine to create a plan for improved lifestyle and long-term adherence to the drug.
What happens when you stop taking Ozempic? Weight loss caused by GLP-1 agonist drugs is not always permanent. In clinical trials, people who stopped taking semaglutide regained the majority of their prior weight loss within a year.
Stop using Ozempic® and call your health care provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.
How Long Can You Stay on Ozempic (semaglutide)? A person can stay on Ozempic® so long as they are tolerating the medication and it is deemed appropriate by their treating provider. There is no specific time frame when someone should stop taking Ozempic as it is a medication that is intended for chronic (long-term) use.
“GLP-1 medications [like Ozempic] are designed to be taken long-term,” explains Dr. McGowan. “They are chronic medications for the treatment of chronic conditions (both diabetes and obesity).”
You'll need to stay on the drug to keep seeing weight loss effects from Ozempic. If you stop taking it, you will most likely regain the weight you've lost.
The drugs also come with a warning that they may increase the risk of thyroid cancer, acute pancreatitis, gallbladder disease, low blood sugar, kidney injury, damage to the eye's retina and suicidal thinking or behavior.
“Ozempic face” is a term for common side effects of the type 2 diabetes medication semaglutide (Ozempic). It can cause sagging and aging of facial skin. A doctor may recommend lifestyle modifications or facial fillers to treat these effects.
It's normal to eventually hit a point where your weight loss slows down, especially if you're not working on keeping or building up your muscle mass. Losing muscle along with fat slows your metabolism and can slow down your weight loss.
For people who are trying to lose weight, whether or not they need to, Ozempic will flush out of your body and you'll go back to where you were, Sadhu said. There's no withdrawal and you don't need to taper off the drug, although you may feel hungry again and regain the weight.
Ideally, you should not take Ozempic if you do not have diabetes, or if you're pregnant, breastfeeding, or planning on becoming pregnant. Ozempic may cause serious (but rare) side effects, including thyroid C-cell tumors and medullary thyroid carcinoma (MTC).
Research has proven that higher doses of Ozempic — 2.4 milligrams of semaglutide — are very effective for reducing weight in people with obesity. In one landmark study, people with obesity who used the drug in combination with lifestyle interventions lost about 15% percent of their body weight in 68 weeks.
So, on average, with the recommended starting Ozempic dose of 0.25 mg, a 500 to 1000 calorie reduced diet, and exercise 3 times a week, you can expect to lose 3-5 pounds in the first month of treatment, which works out to about 3% of body weight for most overweight or obese individuals.
If you're having trouble accessing Ozempic, your healthcare provider may recommend an alternative that works in a similar way. For Type 2 diabetes, this may include Rybelsus, Trulicity, or Mounjaro. If you're taking Ozempic off-label for weight loss, Wegovy and Saxenda are two FDA-approved options.
Describing her experience maintaining her weight loss after stopping semaglutide, Shepherd said, "Absolutely people can get off of it and do it, and I wouldn't be scared to get off of it." Teresa Shepherd, of Florida, said she lost 90 pounds while taking a semaglutide compound for around eight months.
Mounjaro is a more effective drug than Ozempic. As demonstrated above, tirzepatide (the active ingredient in Mounjaro) leads to more clinically significant weight loss and blood sugar reductions than semaglutide (the active ingredient in Ozempic).
Ozempic has a new rival: Mounjaro, also a diabetes drug, has led to average weight losses of 15 to 24 kg. A powerful new diabetes drug is poised to become a hit on the global weight loss market.
Will Ozempic or Wegovy reduce belly fat? The answer appears to be yes. That Novo Nordisk-funded study of almost 2,000 overweight or obese adults without diabetes also found their visceral fat — the type that accumulates in the belly — was reduced from baseline with semaglutide, along with their total fat mass.
Yes, you'll lose weight with semaglutide – until you stop taking it. Then, evidence shows you're likely to regain the weight: one year after discontinuing the use of semaglutide, there was significant weight regain among participants. In fact, participants regained two-thirds of their prior weight loss.