Shortness of breath, a big weight gain, or swelling in the arms or legs. Chest pain or pressure or a fast heartbeat.
Serious side effects
you have severe indigestion, heartburn or stomach pain, vomiting or diarrhoea – these can be signs of an ulcer or inflammation in your stomach or gut. the whites of your eyes or your skin turn yellow, although this may be less obvious on brown or black skin – this can be a sign of liver problems.
Conclusion. This study suggests that the CL of diclofenac is not dependent on age in elderly subjects receiving HPβCD-diclofenac but indicates that diclofenac CL increases with increasing body weight.
Tell your doctor right away if you have any serious side effects, including: signs of kidney problems (such as change in the amount of urine), symptoms of heart failure (such as swelling ankles/feet, unusual tiredness, unusual/sudden weight gain).
Risk of cardiovascular problems. NSAIDs, such as diclofenac, increase your risk of serious cardiovascular problems, including heart attack and stroke. Cardiovascular problems can occur at any time while you're taking diclofenac. In rare cases, they can be fatal.
Renal impairment with NSAIDs and Diclofenac is not solely attributed to these drugs; but to patient's underlying medical conditions and renal function status. Diclofenac may be well tolerated in renally impaired patients when used at the lowest effective dose for the shortest dose duration.
Stop taking diclofenac and get medical help right away if you notice any of the following rare but serious side effects: bloody or black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body ...
Clinicians should be aware that patient-reported weight gain and increases in blood pressure can occur with all NSAIDs, and may be particularly increased with rofecoxib. Existing cardiovascular disease is also an independent predictor of weight gain and increased blood pressure.
Tell your doctor if any of these symptoms are severe or do not go away: diarrhea. constipation. gas or bloating.
Diclofenac is one of the most likely NSAIDs to cause liver injury. In many cases, the damage is significant enough to cause elevated liver function tests (LFTs) but not enough to cause symptoms. LFTs measure liver enzymes (proteins), and increased numbers point to possible liver injury.
There are a number of possible reasons why opioids can be associated with significant weight gain and obesity. For example, they can act as a sedative which makes patients less active and they have been shown to alter taste perception with a craving for sugar and sweet foods.
Prescription NSAIDs that may also cause hair loss include: celecoxib (Celebrex), diclofenac (Voltaren), etodolac (Lodine), fenoprofen (Nalfon), indomethacin (Indocin), ketoprofen (Orudis, Oruvail), oxaprozin (Daypro), nabumetone (Relafen), and sulindac (Clinoril).
First and foremost, contact your healthcare provider. Tell them why you want to stop taking your pain medication and listen to what he or she has to say. There may be new alternatives that will work better for you, or your healthcare provider may simply adjust your dosage.
Diclofenac+Tizanidine is used in pain due to muscle spasm. Diclofenac + Tizanidine is a combination of two medicines: Diclofenac and Tizanidine, which relieves pain and relaxes the muscles.
Is diclofenac a strong painkiller? Diclofenac is used to treat mild to moderate pain.
Paracetamol appears to be preferred mostly in upper respiratory tract infections compared to the preference of diclofenac rather in painful/inflammatory musculoskeletal conditions.
Therapy with diclofenac in full doses is frequently associated with mild serum aminotransferase elevations and, in rare instances, can lead to serious clinically apparent, acute or chronic liver disease.
Lidocaine cream is better than diclofenac gel for nerve pain.
Diclofenac in clinically administered doses does not interfere with the function of platelets and does not cause increased bleeding. Lower CRP in the diclofenac group may indicate a reduced inflammatory response after CPB.
Metaflammation, the metabolic inflammatory state associated with obesity, directly contributes to insulin resistance, metabolic syndrome, and type 2 diabetes. The condition is defined by low-grade chronic inflammation in metabolic tissues, including: Adipose (fat) cells. Liver.
Additionally, improving dietary choices, increasing physical activity, getting more sleep, managing stress levels effectively, quitting smoking, and limiting alcohol are all ways to decrease and avoid hormonal weight gain.
Diclofenac tablets must no longer be sold to anyone without a prescription. Diclofenac is associated with a small risk of serious cardiovascular side effects (eg myocardial infarction and stroke).
Despite the risks associated with taking NSAIDs daily, people who have been taking NSAIDs daily for long periods of time should not stop taking them abruptly. The body's reaction to such a cutoff could make blood clots more likely, adding to the risk of heart attack or stroke.
What is the strongest anti-inflammatory medication? Research shows diclofenac is the strongest and most effective non-steroidal anti-inflammatory medicine available.10 Diclofenec is sold under the prescription brand names Cambia, Cataflam, Zipsor, and Zorvolex.