Kelly Kline was an aide to President
Lydia is an Amazon who hooked up with Dean Winchester at a bar and the two made love in bed. She was impregnated by the older Winchester and in just a few hours, she was pregnant with her unborn child.
When it seems like things can't get any worse, Castiel finds himself pregnant with the spawn of Dean Winchester and Lucifer. Of course, he can't keep his child, not when it could potentially destroy the world, but, as time goes on, he begins to fantasize about the little family he could have.
Kelly Kline (born 1978 - May 18, 2017) was the secret girlfriend and secretary of Jefferson Rooney, the President of the United States, before becoming the mother of Jack Kline, Lucifer's child. Following her son's birth, Kelly passed away and her soul ascended to Heaven.
A heavily pregnant Lydia. Within hours, Lydia becomes pregnant and gets a surprise call from Dean asking about a flask. Lydia tells Dean she's busy and hangs up on him. Several hours later, she gives birth to her and Dean's daughter Emma.
In Plucky Pennywhistle's Magical Menagerie, Dean mentions not wanting to get into bed with any more women in case he makes more babies, a clear reference to Emma. She was killed by her uncle. She is also the second direct relative that Sam killed with the other being Samuel Campbell, Emma's great-grandfather.
When Dean had first met Ben Dean considered the possibility that Ben might actually be his son. Lisa confirmed to Dean that Ben wasn't his son and his similarities to him was due to her 'type' that she hooked up with that Dean had fallen under.
Mazikeen is a character who appears in American comic books published by DC Comics. She is one of the lilim, a child of Lilith. She first appeared in The Sandman (vol. 2) #22 (December 1990), and was created by Neil Gaiman and Kelley Jones.
In season 4, she finds out she's pregnant with Amenadiel's half-angel child. Linda and Amenadiel name their son Charlie in honor of Charlotte.
Castiel is a young Seraphim, former leader of his garrison, and youngest angel in all of Heaven. He is the husband of the demoness, Meg Master and widowed father of his daughter, Cassandra Masters.
Emma Winchester is the daughter of Dean Winchester and Lydia.
Cassandra Masters is the daughter of Castiel and Meg Masters and the only known Nephalem to exist, which is a hybrid between a union of an angel and demon, even being part human due of Castiel and Meg's human vessels. Cassandra acts as one of the leading main characters with Sam and Dean.
Cass reveals that he has learned a lot about being human and reveals he had sex with April, leading the Winchester's to be surprised. Dean even goes onto make a joke about "having protection." Castiel goes to eat and Ezekiel takes over Sam saying Cass can't stay because he will bring the angels down on them.
Dean invites Rory and her mother to his wedding, but after some intervention from Luke (who heard Dean confess his remaining feelings for Rory the night before whilst he was drunk), the two decide to not attend. Dean marries Lindsay in Season 4.
When Dean tells Rory he and Lindsay are engaged, he's obviously seeking her approval and was almost looking for her support. On the night of his bachelor party (a night before the wedding), a drunk Dean falls into bed and says he missed Rory. It's crystal clear: he married Lindsay to get over Rory.
In the series finale, after Dean dies, Sam leaves the bunker behind for good, taking their dog, Miracle, with him. Over the years, Sam has a family and a son, whom he named after his brother, grows old and dies of natural causes. After Sam's death, he and Dean are reunited in Heaven.
Second Birthday. On Charlie's second birthday, he manifested a pair of angel wings, much to his parents' shock (Linda) and joy (Amenadiel).
When Maze went to find her mother, Linda revealed that she had abandoned a child when she was younger. Maze then went out and found Adriana so Linda could meet her. They went to an open house Adrianna was hosting, but did not actually introduce themselves.
However, Lucifer decides that he must return to Hell to keep the demons in line, recognizing that Chloe was his true love, even if Eve was his first. After a tearful goodbye and last kiss with Chloe, Lucifer uses his wings, angelic white once again, to return to his throne in Hell.
Aurora Morningstar, commonly known as Rory, is a central character in Lucifer. She is the Nephilim daughter of Lucifer Morningstar and Chloe Decker. She was raised solely by her mother after Lucifer seemingly abandoned them before she was born, resulting in her resenting her absent father.
Hormin who is mentioned here as the son of Lilith is most probably a result of a scribal error of the word "Hormiz" attested in some of the Talmudic manuscripts. The word itself in turn seems to be a distortion of Ormuzd, the Zoroastrian deity of light and goodness.
Mazikeen, better known by her nickname Maze, is a major protagonist in the TV series Lucifer, serving as the secondary antagonist of Season 3, a major antagonist in Season 5 and a major protagonist in every other season. She is a demon from Hell, the daughter of Lilith and former right-hand of Lucifer Morningstar.
In Byzantium, Sam and Dean outright call Jack their son and God compares Dean killing Jack to a father killing his son in Moriah. Ironically, the Winchesters had started out trying to stop Jack from coming into existence and Dean was the most against and threatening towards him but became the closest to Jack.
Eileen Leahy - Sam's final love (Season 15)
That is until Chuck wiped everyone from existence (“Despair”).
And we're not about that life, especially with the history of fridging that Supernatural has had when it comes to their female characters. Sam and Eileen got married. Dean approved. And they all lived happily ever after.