The Norman version of the Green Goblin is usually regarded as Spider-Man's archenemy.
The Green Goblin, specifically Norman Osborn, is Spider-Man's arch-enemy. Norman barely edges out Doc Ock and Venom for the dubious honor. Osborn is uniquely sadistic and ingenious among Peter's enemies. Osborn's murder of Gwen Stacy is still the deepest wound a super-villain has inflicted on Spider-Man.
It wasn't until Amazing Spider-Man #1 (by Stan Lee and Steve Ditko) that Spider-Man battled a true villain. The first supervillain was The Chameleon, who disguised himself as Spider-Man and made the hero look like a villain.
The Mandarin is a supervillain appearing in American comic books published by Marvel Comics. He is the archenemy of Iron Man. The character was created by Stan Lee and designed by Don Heck, first appearing in Tales of Suspense #50 (Feb. 1964).
Cosmic Spider-Man is undoubtedly the most powerful variation of the character. In the Acts of Vengeance storyline, Peter absorbs a mysterious power known as the Enigma Force.
1. Thanos (Avengers: Infinity War, Avengers: Endgame)
1/10 DOCTOR OCTOPUS
When Doc Ock took over Peter's body and became the Superior Spider-Man, it wasn't just a name. He upgraded everything about Spider-Man, and proved to be the most intelligent villain he ever faced.
The Venom/Spider-Man feud began years ago due to bad journalism, Spider-Man's heroism, and the mutual hatred of one angry symbiote. Though the Lethal Protector has become an anti-hero since the '90s, Venom is still widely regarded as one of Spider-Man's most well-known and iconic villains.
Besides communicating the apparent fact that Venom wants to eat brains — and Peter's looks tasty to Venom — Venom's hunger appears to be proof of an intrinsic attraction to Peter Parker. Now, it's critical to point out that this has never been a real thing in the comics.
File this one under “no-brainer,” Carnage has long since been defined as Venom's true arch-nemesis, even more so than Spider-Man.
While Venom grew to be regarded as one of Spider-Man's archenemies, later comic book storylines depict him as an antihero, and he even reluctantly teamed up with Spider-Man when the lives of innocent people were at risk.
Rhino. Rhino ranks among the best Spider-Man villains in Marvel Comics and certainly among the strongest. He lifts 100 tons in his specialized suit, far beyond Spider-Man's capability, which lies closer to 10 tons.
Spider-Man
Spider-Man redefined what a superhero could be, and although many have followed in his footsteps, he's still number one, definitively at Marvel and arguably anywhere else.
When Thanos had all the Infinity Stones in his possession, he was the most powerful individual in the MCU. Admittedly, without them, he was not quite as mighty, but he remained stronger than most.
Now, thanks to his starring role in Avengers: Infinity War and Endgame, Thanos is not just seen as Marvel's biggest villain but he's a household name in his own right - even recreating his cosmically catastrophic Infinity Gauntlet 'snap' to murder half the Marvel Cinematic Universe, just as he did in Marvel Comics.
Yes, even Spider-Man has been worthy of holding the hammer of Thor.
Like his namesake, Spider-Man's strength and agility stand far above those of the average human, allowing him to lift nearly ten tons and to leap and move at incredible speeds with high accuracy. He also heals faster than normal when injured, though he is not completely immune to viruses and other human ailments.
Ethyl chloride is essentially Spider-Man's Kryptonite and it renders anyone's spider-powers null and void. This makes ethyl chloride extremely powerful against Spider-Man, but this chemical cocktail doesn't have nearly the same reputation as Superman's Kryptonite.
Spider-Man can be pretty silly, but he's tough as nails and his spider-senses and agility, combined with super strength, have allowed him to beat Hawkeye every time they've fought.
The Chameleon (Dmitri Smerdyakov; Russian: Дмитрий Смердяков) is a supervillain appearing in American comic books published by Marvel Comics. He is the first ever adversary of the superhero Spider-Man, having debuted in the initial issue of The Amazing Spider-Man (March 1963).
The Sinister Six appear in Spider-Man: Return of the Sinister Six, consisting of Doctor Octopus, Electro, Sandman, Mysterio, the Vulture, and the Hobgoblin. The Sinister Six appear in Spider-Man 2: The Sinister Six, consisting of Doctor Octopus, Mysterio, Sandman, the Vulture, the Scorpion, and Kraven the Hunter.
Every great hero has an arch nemesis. And for the Black Panther, that man is Erik Killmonger. A fierce and cunning warrior who thinks of himself as a more capable and courageous than T'Challa, Killmonger has opposed the King of Wakanda almost constantly.