Rosuvastatin and atorvastatin are the best at lowering LDL cholesterol.
According to a research review people who take simvastatin (Zocor) or pravastatin (Pravachol) may experience fewer side effects.
Rosuvastatin, at moderate and high intensity doses, and atorvastatin and simvastatin at high intensity doses, were the most effective statin treatment option in the population of 7028 adults at low to medium risk of major cardiovascular events and possible primary prevention.
Similarly, data from comparative trials, shown in Table 1 confirm that rosuvastatin is the most effective statin for lowering LDL-C (reduction of 63% with 40 mg daily), followed by atorvastatin, simvastatin, and pravastatin. The lipid lowering effect of pitavastatin was comparable to atorvastatin.
A lipid profile was determined as baseline, at 4 weeks and again at 8 weeks. Atorvastatin every other day significantly reduced total cholesterol (TC), triglyceride (TG), and LDL-c versus baseline. The TC, TG, and LDL-c levels were lower by 23 per cent, 8 per cent, and 30 per cent.
It turns out that some statins may be better at preventing liver cancer than others. Specifically, lipophilic statins (those that dissolve more readily in lipids such as oils and fats) may be more effective for preventing liver cancer than hydrophilic statins (those that dissolve more readily in water).
In addition, rosuvastatin 5 mg effectively lowers triglycerides (-16%), total cholesterol (-30%), non-high-density lipoprotein cholesterol (non-HDL-C; -38%) and apolipoprotein (apo) B levels (-33%) and increases HDL-C (+8.2-13%) in a wide range of patients with hypercholesterolaemia, including the elderly, obese ...
Despite this, there was no significant difference between the two drugs in how well they decreased the volume of atherosclerotic buildup in the arteries. Both Crestor and Lipitor are generally well tolerated with a similar rate of side effects.
Atorvastatin is the most common cause of clinically significant liver injury among statins with a reported incidence of 1/17 000 users.
In studies, Nexletol also appears to reduce the risk of muscle pain, a common complaint of people on statins. Nexletol (bempedoic acid) is a new cholesterol-lowering drug.
A: Yes. There have been several clinical studies — many of them done here at Cleveland Clinic — that show statins can reverse plaque buildup. Two statins in particular, atorvastatin, which is sold under the brand name Lipitor, and rosuvastatin, which is sold under the brand name Crestor, are the strongest statins.
They looked at the effects of Lipitor, Crestor, Zocor, and Pravachol on lowering LDL (low-density lipoprotein) cholesterol after six weeks. The study concluded that Crestor lowered LDL cholesterol by 8.2% more than Lipitor, and Crestor lowered total cholesterol significantly more than all the other statins studied.
Is muscle pain a side effect of all statins? Even though all statins are similar chemically, they have some minor differences that could impact how likely they are to cause muscle pain. Simvastatin is the most likely to cause muscle pain, and fluvastatin is the least likely.
Statins are the most common medicine for high cholesterol. They reduce the amount of cholesterol your body makes. You take a tablet once a day. You usually need to take them for life.
Inclisiran will only be given to people who are unable to lower their cholesterol with statins and/or lifestyle changes, or are unable to tolerate statin medication.
Statins — Statins are one of the best-studied classes of medications and the most commonly used drugs for lowering LDL cholesterol. They are the most effective drugs for prevention of coronary heart disease, heart attack, stroke, and death.
Statin-associated hepatocellular injury frequently occurs 5 to 90 days after the initiation of therapy. Bilirubin levels more than twice the ULN imply severe hepatocellular liver injury with a mortality of 10% and an incidence of 0.7–1.3 per 100,000 cases of drug-induced liver injury (DILI).
PCSK-9 inhibitors thus reduce cholesterol levels by maintaining higher levels of LDL receptors that remove cholesterol from the blood. Currently, PCSK-9 inhibitors are limited in use as they must be administered as shots. Further research into them could expand their use as an alternative to statins.
There are no specific treatments for NAFLD, but cholesterol-lowering drugs called statins appear to slow its progression to more serious liver inflammation and fibrosis/scarring, characteristics of NASH.
Liver disease: Liver disease can also be a severe side effect of Crestor. Your doctor should do blood tests to check your liver before you start taking Crestor. They should also do these tests if you have symptoms of liver disease while you take the drug.
Federal regulators have approved the new drug Leqvio to be used to help lower cholesterol levels in some people. The medication is designed to be taken along with statins and a balanced diet. Leqvio is designed to be taken twice a year, which experts say should help people adhere to a medication schedule.
If you're taking a statin medication to lower your cholesterol, you will need to keep taking your prescription, or your cholesterol will likely go back up. Stopping your statin can put you at risk of having heart disease and other preventable health problems like stroke and heart attack from high cholesterol.
These prescription drugs lower your risk for heart disease by blocking a substance your body uses to make cholesterol. But statins aren't always enough. One study says that half of people who take statins don't get their cholesterol down to a healthy level after 2 years.
The usual dose for adults is between 10mg and 80mg a day. Your dose depends on the reason why you're taking it, your cholesterol levels, and what other medicines you're taking. Do not reduce your dose without talking to your doctor first.