In relation to renal function, atorvastatin was the safest statin as it resulted in the least number of patients at the end of 2 years of treatment with the new onset of microalbuminuria (10.9%) followed by rosuvastatin (14.3%) and then pravastatin (26.6%).
Atorvastatin seems to be the statin of choice in patients with CKD stages 4–5. Fluvastatin as well as other statins may also be used at more advanced stages of CKD after appropriate dose adjustments.
Compared to use of atorvastatin, use of rosuvastatin was associated with an 8% greater risk of hematuria, a 17% greater risk of proteinuria, and a 15% higher risk of developing kidney failure.
Higher doses of rosuvastatin may have lasting and damaging effects on the kidneys, according to a study published in JASN based on patient health records. Rosuvastatin is in the statin class of drugs indicated to lower high cholesterol.
Although effect estimates and rankings of individual treatments were variable across the analyses, in general atorvastatin 40–80 mg, fluvastatin 20 mg/ezetimibe 10 mg, pravastatin 10–20 mg, simvastatin 10–40 mg, and fluvastatin 20 mg were the most effective treatments with regard to eGFR decline.
Bempedoic Acid: A Statin Alternative to Reduce Cholesterol
Bempedoic acid is sold under the brand name Nexletol on its own and as a combination drug with ezetimibe called Nexlizet.
The Heart Protection Study included more than 20,000 people with cardiovascular disease or diabetes, who received simvastatin 40 mg daily versus placebo [6]. The risk of cardiovascular events was reduced by 18% in subjects aged 70 to 80 years treated with simvastatin and by 24% in those aged less than 65 years [6].
Conclusion: Although the medication caused no severe adverse events, we recommend caution when using atorvastatin for severe CKD patients until further evidence of its safety and efficacy is verified.
WASHINGTON, D.C. – The rate of reports of kidney failure or damage among patients taking the cholesterol drug Crestor is 75 times higher than in all patients taking all other statins, according to a Public Citizen analysis of government data.
Despite this, there was no significant difference between the two drugs in how well they decreased the volume of atherosclerotic buildup in the arteries. Both Crestor and Lipitor are generally well tolerated with a similar rate of side effects.
Some statins require dose adjustments based on renal function, whereas atorvastatin does not. Ezetimibe can be prescribed in patients with CVD and CKD, usually combined with a statin.
The overall risk of statin-induced rhabdomyolysis is low (1 case/10,000 person-years of treatment), and the occurrence of acute kidney injury complicated with rhabdomyolysis is rare (1). Furthermore, rhabdomyolysis with acute kidney injury is usually reversible following statin discontinuation.
Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). Rhabdomyolysis can cause extreme muscle pain, liver damage, kidney failure and death. The risk of very serious side effects is extremely low.
Even though all statins are similar chemically, they have some minor differences that could impact how likely they are to cause muscle pain. Simvastatin is the most likely to cause muscle pain, and fluvastatin is the least likely.
A daily pill, bempodoic acid, has the potential to lower risk of major cardiovascular events such as heart attack or stroke for people who can't or won't take statins.
Rarely, statins may cause bad side effects, including confusion, memory loss, damage to your livers or high blood sugar. The new bempedoic acid drug – currently called Nexletol – is being developed by US-based Esperion Therapeutics and will go to the Therapeutics Goods Administration for approval for use in Australia.
It's important to know that stopping statins cold turkey, or even gradually, can cause serious health problems and you should talk to your doctor before doing so.
Statins can stabilize cholesterol plaque already attached to artery walls, making it less likely to get worse or rupture, causing a heart attack or stroke. "Statins also help remove cholesterol from you blood by causing the liver to express more LDL cholesterol receptors that take cholesterol out of your blood," Dr.
But whether you take statins or not, making changes to what you eat and how you live can have a real effect on your cholesterol levels. By making smart food choices, you may be able to lower your need for statins — or remove that need altogether.
Statins arguably exert protective effects on the kidney in a general adult population and on the cardiovascular system in patients with CKD who do not require dialysis. Adjunctive therapy with statins can dose-dependently prevent CIN and attenuate the CRS.
Statins induce expression of cholesterol transporters such as ABCA1, ABCG1 and SR-BI in the liver and extra-hepatic tissues such as intestine, adipose tissue and skin.
There is evidence that certain medicines called statins can slow the process of both chronic kidney disease and heart disease. These drugs are used to lower high cholesterol levels in the blood, helping slow down the progression of chronic kidney disease.