The Otsutsuki clan is unquestionably the strongest clan in the series. They are extraterrestrial beings who came to the Earth hundreds of years ago, and the first among them were Kaguya and Isshiki. The members of the Otsutsuki clan are knowledgeable about all kinds of abilities.
The short answer to whether the Uzumaki clan is stronger than the Uchihas would be 'yes. ' However, there is a lot to take away from the fights of both legendary clans, since the original story did not touch upon this particular subject. So, the readers should know about the Uzumakis and their roots.
Yamanaka. Of all the Ino-Shika-Cho members, the Yamanaka clan is arguably the weakest. Not because they aren't powerful, but because their abilities work best with a team and are harder to use without comrades around.
The Uzumaki clan is not just the strongest clan in the Hidden Leaf but the entire series. In the past, the Uzumaki Clan was nearly wiped out because the other nations feared them due to their incredible fuinjutsu. Many of the survivors migrated to the Hidden Leaf.
Is Uzumaki stronger than Uchiha? Technically if you look at the Uzumaki clan, it produced the greatest shinobi ever, Naruto. But if we start comparing clans in the anime, the Uchiha clan is way stronger than the Uzumaki clan as it produced a large number of the finest warriors in history.
Obito Uchiha was one of the strongest Uchiha to ever exist. He awakened his Mangekyō Sharingan during the Third Great Ninja War after witnessing Rin die. Obito's eye weilded the Kamui, a powerful space-time ninjutsu.
With Naruto Uzumaki, the Seventh Hokage, being considered the strongest of all time, it is quite clear that the weakest of all Hokage is one of Kakashi Hatake and Tsunade Senju.
1) Madara Uchiha
This man was able to tame tailed beasts which really showcased his strength. As a child, Madara was able to awaken his Sharingan with one Tomoe in each eye. His mastery of the Sharingan and jutsu capabilities makes him far stronger than Kakashi.
He is dubbed by most to be the strongest shinobi in history. Sasuke himself admitted this fact. In the end, while Sasuke may not be able to beat Naruto, even with his perceived weakened state in Boruto, the two did become friends again. A combination of powers that are said to be able to destroy the entire world.
The Nara clan is known for two things: high intelligence and shadow manipulation. Shikamaru Nara and his father Shikaku are two of the smartest minds to ever live in Konohagakure.
The Uzumaki's destruction could, as well, be attributed to the power-thirst of the villages who deemed them as a threat. Even after their destruction, war never stopped as at least one village always desires to be the best over the others.
Jiraiya is a billionaire playboy of that universe per canon :D. Selling these to the outside world, It is estimated that each human body costs up to 45 million dollars.
Senju and Uchiha. Originally Rikudo Sennin started “Ninshu” and he had 2 sons that later becomes Senju and Uchiha clan.
1) Isshiki Otsutsuki
He is stronger than the combined force of Naruto and Sasuke. Although his powers were nerfed because Jigen's body was a weak vessel, he overwhelmed Naruto and Sasuke, and almost killed the latter. Sasuke was able to give a good fight to Isshiki, but he can't fight him alone.
1) Hashirama Senju
Hashirama united the Senju and Uchiha clans and went on to establish Konohagakure. He was unmatched in power during his lifetime and even after death. Hashirama was undefeated in his lifetime.
Naruto's toughest enemy is Kaguya Otsutsuki. He is the mother of all ninjutsu which gave Naruto the most challenging battle of his life. He is a strong villain that couldn't be defeated by Naruto alone.
Who is the god of Uchiha? Indra Otsutsuki is revealed to be the creator/ founder of the renowned Uchiha Clan in Naruto. He was the eldest son of Hagoromo Otsutsuki (The Sage of Six Paths) and the elder brother of Ashura Otsutsuki.
Obito Uchiha is one of the main antagonists of the Naruto franchise. He is a member of Konohagakure's Uchiha clan who was believed to have died during the Third Shinobi World War, his only surviving legacy being the Sharingan he entrusted to his teammate, Kakashi Hatake.
8 Obito Uchiha, The Second Ten-Tails Jinchuriki
The First Hokage, Hashirama Senju, openly admitted to being inferior to him. Given that the Five Kage are weaker than both Hashirama and Madara, they would certainly not have stood any chance against Obito either.