Cytokines can irritate nerve endings in the skin, which can in turn cause persistent itching. Many individuals experience this itchiness in their hands, lower legs or feet, while others feel it throughout their entire body. Patients often report that the itching tends to worsen while they are lying in bed at night.
The lesions are often itchy, scaly, and red to purple. The lymphoma might show up as more than one type of lesion and on different parts of the skin (often in areas not exposed to the sun). Some skin lymphomas appear as a rash over some or most of the body (known as erythroderma).
Itching caused by lymphoma can affect: areas of skin near lymph nodes that are affected by lymphoma. patches of skin lymphoma. your lower legs.
Itching (pruritus) can be a symptom of some types of lymphoma: It is quite common with Hodgkin lymphoma. It is less common with most types of non-Hodgkin lymphoma (other than cutaneous T-cell lymphoma, a type of skin lymphoma).
What is skin lymphoma? Skin lymphoma is a group of rare, usually slow-growing skin cancers that start in lymphocytes, which are a kind of white blood cell. While most lymphocytes are in lymph nodes, a key part of the body's immune system, they are also present in the skin.
The most common sites are in the chest, neck, or under the arms. Hodgkin lymphoma most often spreads through the lymph vessels from lymph node to lymph node. Rarely, late in the disease, it can invade the bloodstream and spread to other parts of the body, such as the liver, lungs, and/or bone marrow.
Common symptoms of having lymphoma include swelling of lymph nodes in your neck, in your armpits or your groin. This is often but not always painless and often could be associated with fevers, or unexplained weight loss, or drenching night sweats, sometimes chills, persistent fatigue.
Association With Blood Cancers
1 Hodgkin itch can develop weeks and even months before other clinical signs of lymphoma.
Severe intractable itch has been reported in lymphoma patients. Some of the most severe pruritic cases in our practice suffer from lymphoma.
Lymphoma can cause a person to feel exceedingly itchy. This itchiness tends to be worse at night, when the person is lying in bed, and in some cases it can lead to an unpleasant burning sensation. In some instances, the itchiness may be accompanied by a rash, while at other times there will be no rash present at all.
See your doctor or a skin disease specialist (dermatologist) if the itching: Lasts more than two weeks and doesn't improve with self-care measures. Is severe and distracts you from your daily routines or prevents you from sleeping. Comes on suddenly and can't be easily explained.
Many types of CTCL start as flat red patches on the skin, which can sometimes be itchy. With darker skin, the patches may appear lighter or darker than the surrounding skin. In the early stages, the skin patches can look like other common conditions such as eczema or psoriasis.
They can help to reduce itching, but don't work for everyone. Your doctor can prescribe antihistamines. There are many different types and they may give you some relief. They tend not to work so well for itching caused by lymphoma or due to jaundice caused by a blocked bile duct.
Blood tests measure the amounts of certain types of cells and chemicals in the blood. They are not used to diagnose lymphoma, but they can sometimes help determine how advanced the lymphoma is.
When lymphoma affects the skin, it may cause a rash that appears as one or more scaly, reddish-to-purple patches, plaques, or nodules. A lymphoma rash, such as mycosis fungoides (MF), can be easy to confuse with other skin conditions, such as psoriasis or eczema, which can cause similar symptoms.
Signs and Symptoms of Hodgkin Lymphoma. You or your child can have (HL) and feel perfectly well. But HL often causes symptoms or changes that should be checked by a doctor.
However, it's less common in those with non-Hodgkin's lymphoma. Itching can occur without rashes. It's believed that chemicals called cytokines, which are released to fight cancer cells, contribute to making the skin itch.
When dealing with lymphoma, these symptoms may come and go and are sometimes referred to as 'B symptoms. ' These symptoms can include a persistent, chronic fever; unintended weight loss, and excessive sweating, especially at night (night sweats).
Swollen lymph nodes, a fever and night sweats may also be symptoms of the cold and flu. However, unlike the cold and flu, non-Hodgkin lymphoma symptoms typically do not go away. If you have symptoms that persist for more than two weeks, or symptoms are recurring and becoming more intense, you should see your doctor.
Stage I adult lymphoma. Cancer is found in one or more lymph nodes in a group of lymph nodes or, in rare cases, cancer is found in the Waldeyer's ring, thymus, or spleen. In stage IE (not shown), cancer has spread to one area outside the lymph system.
The most common symptom of Hodgkin lymphoma is a swelling in the neck, armpit or groin. The swelling is usually painless, although some people find that it aches. The swelling is caused by an excess of affected lymphocytes (white blood cells) collecting in a lymph node (also called lymph glands).
Lymphoma most often spreads to the liver, bone marrow, or lungs. Stage III-IV lymphomas are common, still very treatable, and often curable, depending on the NHL subtype. Stage III and stage IV are now considered a single category because they have the same treatment and prognosis.
Unlike most cancers, rates of Hodgkin lymphoma are highest among teens and young adults (ages 15 to 39 years) and again among older adults (ages 75 years or older). White people are more likely than Black people to develop non-Hodgkin lymphoma, and men are more likely than women to develop lymphoma.