SYNTHETIC ANTIPARASITES The first modern anthelmintic (after mercury and arsenic), Thiabendazole, was developed in 1960. Since then pentamidine (Diamidine) and nitroheterocyclic antiprotozoal drugs such as metronidazole have been developed.
Antinematodal drugs: Albendazole is also used to manage most infections caused by nematodes (roundworms) and is the drug of choice for ascariasis, trichuriasis, trichinosis, cutaneous larva migrans, hookworm, and pinworm infections.
Originating from a single Japanese soil sample and the outcome of the innovative, international collaborative research partnership to find new antiparasitics, the extremely safe and more effective avermectin derivative, ivermectin, was initially introduced as a commercial product for Animal Health in 1981.
For over 25 years, ivermectin has been used to treat parasitic infections in mammals, with a good safety profile that may be attributed to its high affinity to invertebrate neuronal ion channels and its inability to cross the blood-brain barrier in humans and other mammals.
Anthelmintic drugs of choice include: mebendazole for roundworm, pinworm, whipworm and hookworm infections; niclosamide for tapeworm infections, and thiabendazole for trichinosis.
There are two medications that can be used to treat the infection and manage the symptoms. The treatment of choice is diethylcarbamazine (DEC), which kills the microfilariae and adult worms. Albendazole is sometimes used in patients who are not cured with multiple DEC treatments. It is thought to kill adult worms.
Garlic, honey, pumpkin seeds, and papaya seeds are all touted as antiparasitic foods to include in your diet. Some natural practitioners go a step further and recommend a grain-free, sugar-free diet. Others recommend limiting fruit intake in order to further reduce dietary sugars.
The FDA has not authorized or approved ivermectin for the treatment or prevention of COVID-19 in people or animals. Ivermectin has not been shown to be safe or effective for these indications.
The avermectin family of compounds was discovered by Satoshi Ōmura of Kitasato University and William Campbell of Merck. In 1970, Ōmura isolated a strain of Streptomyces avermitilis from woodland soil near a golf course along the south east coast of Honshu, Japan.
Ivermectin is effective for COVID-19: real-time meta analysis of 44 studies, 2021.
Ivermectin –which now is used to fight pests from bed bugs and lice to serious diseases such as lymphatic filariasis – was derived from naturally occurring bacteria in soil.
Ivermectin, an avermectin, acts by interacting with the chloride channel in nerve and muscle cell membranes, resulting in hyperpolarization of the affected cells and consequent paralysis and death of the parasites. The drug also inhibits the reproductive function of the adult femaleO.
Ivermectin is metabolized in the liver, and ivermectin and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1% of the administered dose excreted in the urine. The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.
IgE antibodies are thought to react with the parasite to form immune complexes that are bound by macrophages via surface receptors for the Fc region of IgE. These activated macrophages then kill the parasite.
Nutrition and Supplements
Drink a lot of water to help flush out your system. Eat more fiber, which may help get rid of worms. Probiotics (Lactobacillus acidophilus, Lactobacilus plantarum, Saccharomyces boulardii, and bifidobacteria). Help keep your digestive tract healthy.
The dangers of using ivermectin
Taking large doses or doses intended for animals is dangerous and can result in overdose, causing serious harm including nausea, vomiting, diarrhea, low blood pressure, dizziness, balance problems, seizures, coma, and even death.
Ivermectin is an anti-parasitic agent that has gained attention as a potential COVID-19 therapeutic. It is a compound of the type Avermectin, which is a fermented by-product of Streptomyces avermitilis.
Ivermectin (Stromectol) is a medication used for infections caused by certain parasitic worms found in rural tropical areas.
Ivermectin has a minimal effect on coagulation and concern about mass treatment for this reason appears to be unjustified.
Some of the products that may interact with this drug include: barbiturates (such as phenobarbital, butalbital), benzodiazepines (such as clonazepam, lorazepam), sodium oxybate (GHB), valproic acid.
No, Ivermectin is not an antibiotic. Antibiotics are a class of medicines used to treat bacterial infections. Some common examples of antibiotics are azithromycin, amoxicillin, etc. On the other hand, Ivermectin is an Anthelmintic drug.
The finding that liquid hand soap efficiently destroys all three parasites suggests that soap solutions can be used as first aid measure to clean skin areas accidentally contaminated with the pathogens.