If Zyrtec (cetirizine) isn't working, try a different antihistamine like Allegra (fexofenadine) or Claritin (loratadine), add a nasal corticosteroid spray (Flonase, Rhinocort) for inflammation, use saline nasal rinses to clear irritants, or see a doctor to explore prescription options, combination sprays, or allergy shots (immunotherapy). It's crucial to consult a healthcare provider before changing dosages or starting new treatments, especially if symptoms are severe or you suspect non-allergic rhinitis, say Verywell Health.
Your body's reaction to certain allergens can change over time, which means the medications you were taking might not be as effective. To get to the bottom of why your allergy meds aren't working, you'll want to talk to your healthcare provider. It's possible that it might be time for a specific IgE blood test.
In general, Zyrtec, Claritin, and Allegra are all similarly effective for treating allergies. But some studies suggest Allegra might work slightly better for eye-related symptoms. And Claritin may be slightly less effective than other similar antihistamines.
Your provider may suggest a steroid nose spray if decongestants or antihistamines don't control your symptoms. Steroid sprays that you can buy off the shelf include a fluticasone (Flonase Allergy Relief) and triamcinolone (Nasacort Allergy 24 Hour). Stronger steroid sprays also can be prescribed.
Fexofenadine 180mg is the strongest non-drowsy antihistamine used to treat hay fever, hives (itchy skin), and other allergy symptoms.
These are some examples of prescription allergy medicines:
Fexofenadine and cetirizine are the strongest antihistamines. There are no stronger ones that can be given on prescription. All antihistamines are available over the counter.
If one non-drowsy antihistamine has not worked for you, it's worth trying another one. Can I take 2 different antihistamines together? Sometimes, doctors recommend that people with a severe, itchy skin rash take 2 different antihistamines together for a few days.
Go to the ER or call 911 if you experience symptoms of a severe allergic reaction, including: Swelling of your face, lips, tongue or throat. Difficulty breathing. Chest pain or tightness.
Conquering Allergy Symptoms
“Nasal steroids are good for moderate to severe symptoms, as they are used daily for a period of time,” Dr. Reisacher says. “Antihistamines are good for sneezing and an itchy, runny nose. Saline rinses also help dilute any allergens in the nose.”
Allergy medications that work differently in the body can be safely taken together. For instance, someone taking an oral antihistamine, such as Zyrtec (cetirizine), can also use a corticosteroid (“steroid”) nasal spray, such as Flonase (fluticasone propionate).
Natural remedies for allergy symptoms
Common side effects of cetirizine and levocetirizine include fatigue, drowsiness, sore throat, cough, dry mouth, nosebleed, fever, diarrhea, and vomiting.
Popping two Zyrtec pills probably won't hurt you, but there are better options, says Hill. If your allergies aren't well controlled on a single 10-milligram pill, talk to your allergist or primary care doctor about other ways to reign in your symptoms.
Perennial allergies may occur at any time of year—unrelated to the season—or may last year-round. Perennial allergies are often a reaction to house dust. House dust may contain mold and fungal spores, fibers of fabric, animal dander, dust mite droppings, and bits of insects.
The choice between Claritin and Zyrtec depends on individual needs. Claritin has fewer side effects and is suitable for long-term use, while Zyrtec acts faster and is more effective at relieving severe symptoms. However, Zyrtec may cause drowsiness. Always consult a healthcare provider.
Treating allergic reactions at the emergency room
A person with a severe allergic reaction may feel better with a dose of epinephrine.
The "3-day rule" for allergens means introducing one new allergenic food at a time and waiting 3 to 5 days before introducing another, allowing parents to easily pinpoint which food caused a reaction, though some experts suggest a shorter wait (2-3 days) or even daily introduction for non-high-risk infants, while emphasizing introducing common allergens like peanut, egg, dairy, soy, wheat, tree nuts, and fish early (around 6 months) and regularly (2-3 times a week) to build tolerance and prevent allergies, always starting with tiny amounts and monitoring for signs like hives, swelling, or breathing issues.
Symptoms of anaphylaxis
They usually start within minutes of coming into contact with something you're allergic to, such as a food, medicine or insect sting. Symptoms include: swelling of your throat and tongue. difficulty breathing or breathing very fast.
Common medications like Zyrtec, Allegra, Flonase, and Claritin usually don't stop working. It's time to check for new allergies if your nose is still stuffy and you can't stop sneezing after taking your regular allergy medicine. You may need a new treatment plan, not just more medication.
There's no single "strongest" antihistamine, as potency varies by person, but prescription options like Desloratadine, Levocetirizine (Xyzal), and higher-dose Fexofenadine (Allegra) are considered very powerful for severe allergies, while strong OTC choices include Cetirizine (Zyrtec) and Fexofenadine, offering fast, non-drowsy relief. Stronger antihistamines work by blocking histamine more effectively, but older types (like Benadryl) cause more drowsiness.
If over-the-counter options aren't enough, your allergist may prescribe: Stronger antihistamines. Nasal corticosteroids. Leukotriene modifiers (helpful for people with both allergies and asthma)
However, some generally considered to be among the most powerful prescription antihistamines include Desloratadine (learn more about how it compares to Loratadine in our guide) and Xyzal. For over-the-counter antihistamines, Cetirizine and Fexofenadine are very effective second-generation choices.