Pemphigus is a rare group of autoimmune diseases. It causes blisters on the skin and mucous membranes in the body. It can affect the mouth, nose, throat, eyes, and genitals. Pemphigus vulgaris is the most common type of pemphigus.
Duke dermatologists diagnose autoimmune skin diseases like pemphigus, pemphigoid, scleroderma, morphea, dermatomyositis, dermatitis herpetiformis, vasculitis, lupus, and Sjögren's syndrome -- all of which occur when the body's immune system attacks healthy skin or tissue.
Pemphigus vulgaris occurs when the immune system mistakenly attacks proteins in the upper layers of the skin. People have severe blistering in the mouth and on other areas of the body, and sometimes sheets of skin peel off.
Autoimmune disease happens when the body's natural defense system can't tell the difference between your own cells and foreign cells, causing the body to mistakenly attack normal cells.
Mild Fever
If you're running a higher temperature than normal, it could be that your immune system is starting to overwork. That can happen due to an oncoming infection or because you're starting to have a flare of an autoimmune condition.
Symptoms of sensitive skin, especially itching, are also common in some autoimmune connective tissue diseases, including dermatomyositis, systemic lupus erythematosus, Sjogren syndrome, systemic sclerosis, as well as mixed connective tissue disease.
Asherson's syndrome is an extremely rare autoimmune disorder characterized by the development, over a period of hours, days or weeks, of rapidly progressive blood clots affecting multiple organ systems of the body.
Necrotising fasciitis, also known as the "flesh-eating disease", is a rare and life-threatening infection that can happen if a wound gets infected.
Skin signs
The common skin manifestation of Sjögren syndrome include: Dry, rough skin (xerosis), in 50% of patients. Reduced sweating (hypohidrosis) Vaginal dryness. Small vessel vasculitis (in up to 30% of patients with SS, usually affecting the legs)
Systemic lupus erythematosus can affect many parts of the body, including the skin, joints, heart, lungs, kidneys, circulating blood cells, and brain. Vitiligo happens when skin cells that make pigment are destroyed causing patches of skin to lose pigment or color.
Melanoma – Nearly 80% of skin cancer-related deaths are caused by melanoma. People who develop melanoma often notice sores that don't heal, areas of darker pigmentation spreading out from a mole, or quickly growing or changing spots.
Some common autoimmune diseases, including Type 1 diabetes mellitus, are relatively easy to diagnose, while others, such as vasculitis, Addison's disease, lupus, and other rheumatic diseases, are more difficult.
Common skin diseases worldwide include eczema, psoriasis, acne, moles, and fungal infections. Symptoms can be similar between conditions, but the treatment will vary.
Your body works to protect the wound by sending nutrient-rich blood to the injury to help regenerate new skin. This healing process depends on healthy immune cells. But if your immune system is sluggish, your skin can't regenerate. Instead, your wounds linger and have a hard time healing.
Ichthyosis is a group of rare skin conditions that cause dry, scaly skin. It's usually something you're born with, but it can happen later in life. It cannot usually be cured, but there are treatments to help the symptoms.
Flesh-eating bacteria (necrotizing fasciitis) is a rare infection of the skin and tissues below it. It can be deadly if not treated quickly. Necrotizing fasciitis spreads quickly and aggressively in an infected person. It causes tissue death at the infection site and beyond.
Background: Autoimmune diseases are multifactorial with environmental and heritable factors. Autoimmunity reflects an altered immune status, therefore the presence of more than one disorder is not uncommon. The coexistence of three or more autoimmune diseases in a patient constitutes multiple autoimmune syndrome (MAS).
Diseases like lupus, rheumatoid arthritis and multiple sclerosis are complex and serious. Although there are no cures for these diseases, many of their symptoms can be treated, and sometimes they go into remission.
What causes sensitive skin reactions? Causes of sensitive skin reactions include: Skin disorders or allergic skin reactions such as eczema, rosacea, or allergic contact dermatitis. Overly dry or injured skin that can no longer protect nerve endings, leading to skin reactions.
A biopsy is usually needed for a definitive diagnosis of autoimmune skin disease, although a characteristic appearance may be suggestive of a particular condition [9]. Blood tests may include: Tests for circulating skin autoantibodies (indirect immunofluorescence) [14]
Autoimmune disorders in general cannot be cured, but the condition can be controlled in many cases. Historically, treatments include: anti-inflammatory drugs – to reduce inflammation and pain.
Signs of a weak immune system include frequent colds, infections, digestive problems, delayed wound healing, skin infections, fatigue, organ problem, delayed growth, a blood disorder, and autoimmune diseases. The immune system helps protect the body from harmful pathogens and other environmental risks.