Cases of myocarditis and pericarditis after COVID-19 vaccines are rare: mostly reported in males under 40 years of age, after the second dose. Cases do occur in both females and males, at any age, and after any dose, including a third or fourth dose.
Guillain-Barré Syndrome (GBS) after COVID-19 Vaccination
GBS is a rare disorder in which the body's immune system damages nerve cells, causing muscle weakness and sometimes paralysis.
Common side effects of COVID-19 vaccination
Most side effects are mild and should not last longer than a week, such as: a sore arm from the injection. feeling tired. a headache.
Capillary leak syndrome (CLS) emerged as new adverse event after immunization (AEFI) associated to COVID-19 vaccination. CLS is a rare condition characterized by increased capillary permeability, resulting in hypoalbuminemia, hypotension, and edema mainly in the upper and lower limbs.
COV2. S vaccination was associated with GBS and that GBS after BNT162b2 and mRNA-1273 may represent background incidence. Importance Because of historical associations between vaccines and Guillain-Barré syndrome (GBS), the condition was a prespecified adverse event of special interest for COVID-19 vaccine monitoring.
In clinical studies, the most commonly reported (≥10%) adverse reactions in participants 16 through 55 years of age following any dose were pain at the injection site (88.6%), fatigue (70.1%), headache (64.9%), muscle pain (45.5%), chills (41.5%), joint pain (27.5%), fever (17.8%), and injection site swelling (10.6%).
Affected patients can present with limb or cranial-nerves weakness, loss of deep tendon reflexes, sensory and dysautonomic symptoms. The main pathophysiology for the clinical presentation is demyelination and/or axonal damage to peripheral nerves or roots.
Serious side effects from vaccines are extremely rare. For example, if 1 million doses of a vaccine are given, 1 to 2 people may have a severe allergic reaction. Signs of a severe allergic reaction can include: Difficulty breathing.
There was a recent report of Ramsey Hunt Syndrome (RHS after the Pfizer vaccination. RHS leads to facial nerve palsy, vestibulocochlear neuropathy, and glossopharyngeal nerve neuropathy, so it causes numbness of the face, tongue, and hearing loss.
People who should not have the Pfizer vaccine
anaphylaxis after exposure to any component of the vaccine, including polyethylene glycol (PEG) myocarditis and/or pericarditis attributed to a previous dose of the vaccine. any other serious adverse event attributed to a previous dose of an mRNA(Pfizer or Moderna) vaccine.
3.4.
The most common complication, stroke, was reported in 39.9% of cases, followed by 15% of MI and pulmonary embolism each, and myocarditis in 11% of the cases with any dose. The remainder 19.1% of the events comprised 43 cases of thrombosis, and 13 cases of pericarditis after any dose.
Acute Liver Injury
It's unclear whether the virus harms the liver or if it happens for another reason, but besides the lungs, the liver usually suffers the biggest injuries from COVID-19. Acute liver injury and liver failure are life-threatening complications.
Autoimmune hemolytic anemia, immune thrombocytopenic purpura, autoimmune thyroid diseases, Kawasaki disease, Guillain-Barre syndrome, and the detection of autoantibodies are the cues to the discovery of the potential of COVID-19 in inducing autoimmunity.
Nationwide, some people who recovered from COVID-19 have reported neurological concerns such as dizziness, headache, lingering loss of taste or smell, muscle weakness, nerve damage and trouble thinking or concentrating — sometimes called “COVID fog” or “brain fog”.
We found a total of 11 reports describing 14 cases of psychiatric reactions; these were mostly altered mental states, psychosis, mania, depression, and functional neurological disorder. The index case was commonly a young or middle-aged adult. All reports pertained to the use of either mRNA or vector-based vaccines.
According to the Vaccine Injury Table, symptoms of GBS after a flu shot should manifest 3-42 days following vaccination to bring an on-Table claim, although it is still possible to file a successful claim if symptoms do not strictly fall within this time period.
A self-controlled case series found an increased risk of GBS during a 42-day period after vaccination with Shingrix [11]. The study also found an estimated three cases of GBS per million vaccinations administered in adults aged 65 and older [11].
Dressler syndrome is inflammation of the sac surrounding the heart (pericarditis). It's believed to occur as the result of the immune system responding to damage to heart tissue or damage to the sac around the heart (pericardium). The damage can result from a heart attack, surgery or traumatic injury.
Myocarditis presents similarly to pericarditis, with a range of symptoms including: chest pain, pressure or discomfort. pain with breathing (pleuritic chest pain) shortness of breath.
Myocarditis occurs when the heart muscle (myocardium) becomes inflamed. Inflammation occurs when your body's immune system responds to infections, for example. Myocarditis can be caused by viral infections or more systemic inflammatory conditions such as autoimmune disorders.
Risks include: Rare Severe Allergic Reaction: There is a remote chance the vaccine could cause a severe allergic reaction (difficulty breathing, swelling of face and throat, fast heartbeat, bad rash all over your body, dizziness, weakness), which would usually occur a few minutes to one hour after getting the dose.
If you are allergic to polyethylene glycol (PEG), you should not get Pfizer-BioNTech or Moderna COVID-19 vaccine. If you are allergic to polysorbate, you should not get Novavax or J&J/Janssen COVID-19 vaccine.