What is the most gentle statin?

Which cholesterol-lowering drug is the safest? Overall, statins are safe as a class of drugs. Serious adverse events are very rare. Among the individual medications, studies have shown that simvastatin (Zocor®) and pravastatin (Pravachol®) seem to be safer and better tolerated than the other statins.

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What is the mildest statin to take?

According to a research review people who take simvastatin (Zocor) or pravastatin (Pravachol) may experience fewer side effects.

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What is the statin drug with the least side effects?

In the analysis of 135 previous studies, which included nearly 250,000 people combined, researchers found that the drugs simvastatin (Zocor) and pravastatin (Pravachol) had the fewest side effects in this class of medications.

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Which statin drug is best tolerated?

Statins are not associated with cancer risk but do result in a higher odds of diabetes mellitus. Among individual statins, simvastatin and pravastatin seem safer and more tolerable than other statins.

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Which statin is least likely to cause muscle pain?

Even though all statins are similar chemically, they have some minor differences that could impact how likely they are to cause muscle pain. Simvastatin is the most likely to cause muscle pain, and fluvastatin is the least likely.

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Study Confirms What Many Patients Taking Statins Have Said for Years | NBC Nightly News

26 related questions found

Is there a statin that doesn't cause muscle weakness?

Try a different statin

The hydrophilic statins, including rosuvastatin (Crestor®) and pravastatin (Pravachol®), have to be actively transported and cause fewer muscle aches. If you haven't tried a hydrophilic statin, talk to your doctor about switching to one.

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Which statin causes the most joint pain?

In other words, statins were not good pain medications. Atorvastatin (Lipitor) use was associated with a reduced risk of developing pain, whilst rosuvastatin (Crestor) leads to a higher risk of developing pain.

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What is the new cholesterol drug that is not a statin?

In studies, Nexletol also appears to reduce the risk of muscle pain, a common complaint of people on statins. Nexletol (bempedoic acid) is a new cholesterol-lowering drug.

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Which statin is least likely to cause liver?

Adverse Effects and Hepatotoxicity

Simvastatin, lovastatin, fluvastatin, and atorvastatin are metabolized by cytochrome P-450, while pravastatin, rosuvastatin, and pitavastatin remain almost unaffected by any hepatic metabolic processes.

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Which is safer Lipitor or Crestor?

Despite this, there was no significant difference between the two drugs in how well they decreased the volume of atherosclerotic buildup in the arteries. Both Crestor and Lipitor are generally well tolerated with a similar rate of side effects.

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Is there a new statin without side effects?

Another newer option is actually a statin. It's called pitavastatin, or Livalo. It has the same LDL- and total cholesterol-lowering property as all the other statins, but somehow doesn't give the muscle aches. A lot of people have had a lot of success taking this over any of the other statins out there.

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What is the number 1 cholesterol medications?

Statins are one of the better-known types of cholesterol-lowering drugs. Providers choose these for the majority of people because they work well. Statins decrease cholesterol output by blocking the HMG CoA reductase enzyme that the liver uses to make cholesterol. Statins are also called HMG CoA reductase inhibitors.

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What is the first drug of choice for cholesterol?

Statins are the most common medicine for high cholesterol. They reduce the amount of cholesterol your body makes. You take a tablet once a day. You usually need to take them for life.

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What can I take instead of a statin?

7 cholesterol-lowering alternatives to statins
  • Fibrates. Mostly used for lowering triglyceride levels in patients whose levels are very high and could cause pancreatitis. ...
  • Plant stanols and sterols. ...
  • Cholestyramine and other bile acid-binding resins. ...
  • Niacin. ...
  • Policosanol. ...
  • Red yeast rice extract (RYRE) ...
  • Natural products.

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Does joint pain from statins go away?

Some symptoms may go away as you continue to take the medication. If you're taking the statin preventively, your doctor may try to determine if your muscle pain symptoms are actually due to the statin by suggesting a brief holiday from the drug to see if they disappear when you're not taking it.

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Can you get off statins once you start?

If you're taking a statin medication to lower your cholesterol, you will need to keep taking your prescription, or your cholesterol will likely go back up. Stopping your statin can put you at risk of having heart disease and other preventable health problems like stroke and heart attack from high cholesterol.

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What is the safest and most effective statin?

Which cholesterol-lowering drug is the safest? Overall, statins are safe as a class of drugs. Serious adverse events are very rare. Among the individual medications, studies have shown that simvastatin (Zocor®) and pravastatin (Pravachol®) seem to be safer and better tolerated than the other statins.

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How long does it take for statins to damage liver?

Statin-associated hepatocellular injury frequently occurs 5 to 90 days after the initiation of therapy. Bilirubin levels more than twice the ULN imply severe hepatocellular liver injury with a mortality of 10% and an incidence of 0.7–1.3 per 100,000 cases of drug-induced liver injury (DILI).

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Which statin affects the liver the most?

Atorvastatin is the most common cause of clinically significant liver injury among statins with a reported incidence of 1/17 000 users.

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What to do if you can't tolerate statins?

Fibrates. Doctors often prescribe a fibrate for patients who can't take a statin. Like the statins, fibrates reduce the body's cholesterol production, but they are less effective in lowering LDL cholesterol levels.

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What is the best natural alternative to statins?

9 Natural Cholesterol Reducers
  • Niacin.
  • Soluble fiber.
  • Psyllium.
  • Phytosterols.
  • Soy.
  • Garlic.
  • Red yeast rice.
  • Ginger.

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What is the new treatment for high cholesterol?

Federal regulators have approved the new drug Leqvio to be used to help lower cholesterol levels in some people. The medication is designed to be taken along with statins and a balanced diet. Leqvio is designed to be taken twice a year, which experts say should help people adhere to a medication schedule.

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How do you know if a statin is causing muscle pain?

Rhabdomyolysis or milder forms of muscle inflammation from statins can be diagnosed with a blood test measuring levels of the enzyme creatinine kinase. If you notice moderate or severe muscle aches after starting to take a statin, contact your doctor.

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Which muscles ache with statins?

Statin-related muscle pain, if it happens at all, usually happens within the first few months after you start the drug or raise the dose. You may feel a constant soreness or weakness in your shoulders, thighs, hips, or calves. If you're like most people, it'll affect both sides of your body equally.

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Why do statins make your legs ache?

According to the research, published in JACC: Basic to Translational Science, statins cause spontaneous and irregular leaks of calcium from storage compartments within muscle cells. Under normal conditions, coordinated releases of calcium from these stores make the muscles contract.

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