Stage 1E lymphoma means that the lymphoma started in a single body organ outside the lymphatic system (for example, the liver) and is in only that organ. This is called extranodal lymphoma.
Stage I adult lymphoma. Cancer is found in one or more lymph nodes in a group of lymph nodes or, in rare cases, cancer is found in the Waldeyer's ring, thymus, or spleen. In stage IE (not shown), cancer has spread to one area outside the lymph system.
More than 80 percent of all patients diagnosed with Hodgkin lymphoma can be cured by current treatment approaches. The cure rate is higher, approaching 90 percent, in younger patients and those with early-stage favorable disease. Even if disease recurs, many patients can be cured with further treatment.
Lymphomas can start anywhere in the body where lymph tissue is found. The major sites of lymph tissue are: Lymph nodes: Lymph nodes are bean-sized collections of lymphocytes and other immune system cells throughout the body, including inside the chest, abdomen, and pelvis.
Lymphoma develops when white blood cells called lymphocytes grow out of control. Lymphocytes are part of your immune system, which helps to fight infection. Lymphocytes travel around your body in the lymphatic system carrying a fluid called lymph.
Physical exam. Your doctor checks for swollen lymph nodes, including in your neck, underarm and groin, as well as a swollen spleen or liver. Removing a lymph node for testing. Your doctor may recommend a lymph node biopsy procedure to remove all or part of a lymph node for laboratory testing.
Swollen lymph nodes, fever, and night sweats are common symptoms of lymphoma. Symptoms of lymphoma often depend on the type you have, what organs are involved, and how advanced your disease is. Some people with lymphoma will experience obvious signs of the disease, while others won't notice any changes.
Blood Tests for Lymphoma
Blood tests are essential to accurately diagnosing this complex disease. These tests can show whether you have lymphoma cells or abnormal levels of normal cells: Blood smear: We take a drop of blood and look at it under a microscope.
Limited (early) stage Hodgkin lymphoma
Limited stage usually means stage 1 or 2A lymphoma. You will probably have a short course of chemotherapy if you have limited disease. Your doctor might then recommend radiotherapy to the affected lymph nodes. You might also have radiotherapy to your spleen or other lymph nodes.
Blood Tests
A low level of red blood cells, white blood cells or platelets may indicate that the lymphoma is present in the bone marrow and/or blood.
Anaplastic large cell lymphomas (ALCL) may come with symptoms such as fever, backache, painless swelling of lymph nodes, poor appetite, itchy skin, rashes and fatigue. Angioimmunoblastic T-cell lymphoma (AITL) often causes symptoms such as fever, night sweats, rashes and itchy skin.
After five to 10 years, low-grade disorders begin to progress rapidly to become aggressive or high-grade and produce more severe symptoms. This type progresses fairly rapidly without treatment.
Stage II is divided into stages II and IIE. In stage II, cancer is found in two or more groups of lymph nodes that are either above the diaphragm or below the diaphragm. In stage IIE, cancer has spread from a group of lymph nodes to a nearby area that is outside the lymph system.
The best way to find lymphoma early is to pay attention to possible signs and symptoms. One of the most common symptoms is enlargement of one or more lymph nodes, causing a lump or bump under the skin which is usually not painful. This is most often on the side of the neck, in the armpit, or in the groin.
It takes time but most people adjust well to life after a diagnosis of lymphoma and find a 'new normal'. This might involve making some changes to your everyday life.
Hodgkin lymphoma is considered one of the most treatable cancers, with more than 90 percent of patients surviving more than five years. Most patients with Hodgkin lymphoma live long and healthy lives following successful treatment.
Lymphoplasmacytic lymphoma or Waldenstrom macroglobulinemia.
This is a rare, slow-growing type of lymphoma. It's found mainly in the bone marrow, lymph nodes, and spleen. This type of lymphoma can't be cured. But people can live with it for many years.
Radiotherapy is most often used to treat early-stage non-Hodgkin lymphoma, where the cancer is only in one part of the body. How long you will need treatment for will depend on the type of non-Hodgkin lymphoma you have and what stage it's at.
Computed tomography (CT) scan
This scan can help tell if any lymph nodes or organs in your body are enlarged. CT scans are useful for looking for lymphoma in the abdomen, pelvis, chest, head, and neck. CT-guided needle biopsy: A CT can also be used to guide a biopsy needle into a suspicious area.
You might have an ultrasound scan to help diagnose non-Hodgkin lymphoma. Ultrasound scans are useful for looking at individual organs such as the liver and kidneys and showing any changes.
To diagnose non-Hodgkin lymphoma, NYU Langone doctors perform a biopsy, in which they take a tissue sample from a swollen lymph node found during the physical exam or with imaging tests, such as CT, PET, or MRI, which doctors often use when diagnosing cancer, and evaluate it under a microscope.
Lymph nodes can swell for a variety of reasons and are considered to be enlarged if they are bigger than 1.5 centimeters in diameter, or slightly larger than a pea. Typically, lymph nodes that are enlarged due to lymphoma are much bigger and can grow to be the size of a grape (or larger).
The lumps may be confined to one area of the body, such as the neck, or develop in multiple areas, such as the neck, armpits and groin. Lymphoma lumps have a rubbery feel and are usually painless. While some lymphoma lumps develop within a matter of days, others can take months or even years to become noticeable.