For individuals with fibromyalgia, magnesium malate and magnesium glycinate are often considered the best forms due to their high absorption rates and specific benefits for muscle pain and relaxation.
Magnesium citrate
Because magnesium is important for both energy production and muscle function, some people with fibromyalgia choose citrate as a form that may be easier for the body to use.
Top Vitamins for Fibromyalgia Relief: A Guide to Managing...
Omega-3 supplements are quite safe and may improve other aspects of health, such as lipid profiles. Magnesium deficiency appears to be more common in patients with fibromyalgia, and deficiency is correlated with fibromyalgia symptoms.
Choose a complex if you want comprehensive magnesium support, or glycinate if you specifically need better sleep and stress support with minimal digestive effects.
Treatment options have historically been limited, and many patients report inadequate relief. On August 15, 2025, the U.S. Food & Drug Administration (FDA) approved a new treatment: Tonmya (cyclobenzaprine HCl sublingual tablets), marking the first new FDA-approved drug for fibromyalgia in more than 15 years.
Several studies have mentioned the correlation between a low concentration of vitamin D and non-specific musculoskeletal pains [3,12,13], while, some other studies reported the probable association between vitamin D deficiency and clinical manifestations of FM [1,3,4,5,14].
Foods to Eat With Fibromyalgia
Eating lots of fruits and vegetables can improve the health of a fibromyalgia patient. Fruits and vegetables are low in calories and high in fiber and antioxidants. Vitamins A, C, and E are found in fresh fruits and veggies, and these also fight free radicals to keep your body normalized.
TNX-102 SL (Tonmya; Tonix Pharmaceuticals), cyclobenzaprine HCl sublingual tablets, has been approved by the FDA to treat fibromyalgia in adult patients, making it the first new treatment approved for the musculoskeletal and chronic pain disorder in over 15 years and the fourth treatment approved overall.
Magnesium malate is best used for muscle soreness, chronic inflammation, fibromyalgia, and improving energy.
However, if you ingest high doses of any magnesium supplement, you might experience side effects, such as diarrhea, gastrointestinal irritation, nausea, vomiting and worse. If too much magnesium builds up in your body, as can happen if you have kidney disease, you can have serious side effects.
Gentle movement exercises, such as tai chi or yoga, can help with fibromyalgia-related pain. If you're living with fibromyalgia, it's important to make time for self-care. It's a chronic (long-lasting) condition that causes muscle pain and tenderness all over the body.
Physical and Emotional Exertion
Engaging in physical or emotional activities beyond one's capacity can lead to fibromyalgia flares. Overexertion, such as intense exercise or prolonged periods of physical activity, can strain the muscles and trigger pain.
While no single treatment works for every patient, many individuals living with fibromyalgia report symptom relief through increased hydration. In fact, a data analysis by a crowdsourced medical platform indicated that nearly 80% of users found drinking more water helpful in managing their symptoms.
1. Vitamin D. Vitamin D is one of the most widely studied supplements for fibromyalgia, Arkfeld says, and it may be helpful because so many people don't have adequate levels of vitamin D in their body.
Inflammatory autoimmune diseases also commonly co-occur with fibromyalgia. Those autoimmune diseases include: Rheumatoid arthritis (RA) Lupus.
Several rheumatic diseases can mimic fibromyalgia. These include sero-negative rheumatoid arthritis, ankylosing spondylitis, Lyme disease, polymyalgia rheumatica and lupus. They have symptoms of widespread pain along with joint involvement.
Tonix Pharmaceuticals announces FDA approval of Tonmya™ (cyclobenzaprine HCl sublingual tablets) for the treatment of fibromyalgia. News release. Tonix Pharmaceuticals. August 15, 2025.
Milnacipran (brand name: Joncia®) belongs to a class of medicines called serotonin and noradrenaline reuptake inhibitors (SNRI). Other similar drugs from this group are used to treat depression and anxiety, but in Australia milnacipran is approved specifically to treat fibromyalgia.
Individuals with diabetes, intestinal disease, heart disease, or kidney disease should avoid magnesium unless specifically instructed by their healthcare provider. Overdose: Signs of a magnesium overdose include nausea, diarrhea, low blood pressure, muscle weakness, and fatigue.
Magnesium deficiency symptoms start mild with fatigue, weakness, loss of appetite, nausea, vomiting, and headaches, but progress to more severe issues like muscle cramps/spasms, numbness, tingling, anxiety, insomnia, abnormal heart rhythms, and even seizures, affecting nerve, muscle, and brain function crucial for overall health.
Can You Combine Them? Yes! Combining Magnesium L-Threonate and Magnesium Glycinate can offer a comprehensive approach to magnesium supplementation. For example, you might take Magnesium Glycinate at night for relaxation and muscle support while using Magnesium L-Threonate during the day for cognitive enhancement.
Fibromyalgia flare-ups can be caused by various factors such as stress, injury, illness, hormonal changes, changes in treatment or routine, diet, lack of sleep, overdoing it, and even changes in the weather! All these factors disrupt the body's pain system, which involves the nervous, immune, and endocrine systems.