Muscular dystrophy is a group of inherited diseases characterized by weakness and wasting away of muscle tissue, with or without the breakdown of nerve tissue. There are 9 types of muscular dystrophy, with each type involving an eventual loss of strength, increasing disability, and possible deformity.
What is muscular dystrophy? Muscular dystrophy (MD) refers to a group of more than 30 genetic diseases that cause progressive weakness and degeneration of skeletal muscles used during voluntary movement. These disorders vary in age of onset, severity, and pattern of affected muscles.
Myasthenia gravis. Myopathy. Myositis, including polymyositis and dermatomyositis.
Cachexia is a condition that causes extreme weight loss and muscle wasting. It is a symptom of many chronic conditions such as cancer, chronic renal failure, HIV, and multiple sclerosis. Cachexia predominantly affects people in the late stages of serious diseases like cancer, HIV or AIDS, and congestive heart failure.
Myositis (my-o-SY-tis) is a rare type of autoimmune disease that inflames and weakens muscle fibers. Autoimmune diseases occur when the body's own immune system attacks itself. In the case of myositis, the immune system attacks healthy muscle tissue, which results in inflammation, swelling, pain, and eventual weakness.
Viruses or bacteria may invade muscle tissue directly, or release substances that damage muscle fibers. Common cold and flu viruses, as well as HIV, are just a few of the viruses that can cause myositis.
Scientists have found that a major reason people lose muscle is because they stop doing everyday activities that use muscle power, not just because they grow older. Muscular atrophy is the decrease in size and wasting of muscle tissue. Muscles that lose their nerve supply can atrophy and simply waste away.
Duchenne muscular dystrophy (DMD) is the most common inherited neuromuscular disorder that affects all races and ethnicities. DMD only affects males.
A doctor may order a blood test for an enzyme called creatine kinase (CK), which leaks out of muscles that are deteriorating. This is a nonspecific test because CK levels are elevated in many neuromuscular diseases, but it's often a useful test.
In multiple sclerosis (MS), two types of atrophy are common: muscle atrophy (due to disuse of specific muscles) and brain or cerebral atrophy (due to demyelination and destruction of nerve cells).
Symptoms include general muscle weakness and possible joint deformities; disease progresses slowly; shortened life span. Symptoms include general muscle weakness and wasting; affects pelvis, upper arms, and upper legs; eventually involves all voluntary muscles; survival beyond 20s is rare.
Muscle mass decreases approximately 3–8% per decade after the age of 30 and this rate of decline is even higher after the age of 60 [4,5]. This involuntary loss of muscle mass, strength, and function is a fundamental cause of and contributor to disability in older people.
The main muscles to be affected are around the shoulders, hips and thighs. Having myositis can also lead to other parts of the body being affected, such as the skin, lungs or heart. Sometimes myositis can affect the muscles that carry out tasks such as breathing and swallowing.
Polymyositis most commonly affects adults in their 30s, 40s or 50s. Women are affected more often than men. Signs and symptoms usually develop gradually, over weeks or months.
Recent studies show that vitamin D deficiency may be responsible for muscle atrophy.
How long it takes to will depend on the amount of atrophy that occurred and your physical condition beforehand. It will take at least two weeks of physical therapy before you start to feel a difference in your muscles. It can take several months of physical therapy for muscle size and strength to be fully restored.
People with severe heart failure can develop muscle wasting and weakness, which makes it difficult to perform everyday tasks or exercise.
Among metabolic myopathies that can mimic myositis are disorders of carbohydrate metabolism such as McArdle's disease, 6-phosphofructokinase deficiency, and Pompe's disease (adult acid maltase deficiency); disorders of lipid metabolism such as carnitine deficiency and carnitine palmitoyltransferase 2 (CPT2) deficiency; ...
Anything that causes swelling in the muscles – including injury, vigorous exercise, infection or exposure to some viruses (the common cold and flu) – can trigger myositis. Certain medications (such as statins) and illegal drugs (like cocaine) can cause myositis, too.