Previous studies have shown that PPIs can damage the "Teflon-like" lining of blood vessels, which are designed to prevent buildup. A PLOS ONE Circulation report in 2013 suggested how PPIs might cause long-term cardiovascular disease and increase heart attack risk.
PPIs are very effective agents for short-term control of gastric acidity when indicated. However, long-term use is not FDA approved, and accumulating data suggest that chronic exposure to PPIs increases the risk of myocardial infarction, renal failure, and dementia.
There is some evidence that omeprazole or esomeprazole may prevent clopidogrel from working as effectively, leading to more heart attacks among people who took both drugs. This evidence is limited, though, and some trials have suggested there may not be an issue. If you have concerns, speak to your doctor.
Most people who take Nexium temporarily will only experience mild gut-related side effects. Nausea, constipation, and diarrhea are the most common culprits. Long-term Nexium use may increase the risk of more rare side effects, such as low magnesium or vitamin B12 levels, bone fractures, and kidney problems.
The concerns around their extended use are that they may lead to increased risk of bone fractures, vitamin B and magnesium deficiencies, and infection with Clostridium difficile bacteria, which can cause serious bowel damage and in some vulnerable people, lead to an increased risk of premature death.
Do not use Nexium 24HR for longer than 14 days unless your healthcare professional directs you to do so. You can repeat a 14-day regimen once every four months.
Prolonged treatment (greater than 24-36 months) may cause vitamin B12 deficiency. The risk is greater in women, people aged less than 30, and with higher dosages. Administration of PPIs (such as Nexium), has been associated with acute interstitial nephritis, a severe inflammation of the kidneys.
Long-term and inappropriate use of PPIs like Nexium have been linked to kidney problems. It can increase the risk of developing acute interstitial nephritis, chronic kidney disease and acute kidney injury. Kidney damage may be irreversible and can progress to organ failure.
If you have allergies to any medications or medication ingredients, especially if they're in esomeprazole or other PPIs. If you take blood thinners, methotrexate, HIV medications, antifungal drugs or any other medications that may interact with Nexium. If you take vitamins or supplements, including St. John's Wort.
Antacids are among the safest drugs for acid reflux and side effects are rare.
In some cases, an individual may have an allergic reaction to the medication, and patients should seek urgent medical attention if any of the following symptoms occur: Difficulty breathing. Tight chest or throat. Severe stomach pain.
What does heartburn have to do with your heart? Nothing! Despite its name, heartburn, or acid indigestion, is related to your esophagus. But because the esophagus and heart are located near each other, either one can cause chest pain (angina).
few common problems are abdominal pain, diarrhea, and headache.” He further added that antacids are linked to causing cardiovascular diseases. Many reports have stated a cause-and-effect relationship between antacids and the heart – however, a definitive relationship is yet to be proven.
The most common PPIs in use were omeprazole (Prilosec), pantoprazole (Protonix), and esomeprazole (Nexium). All participants were free of dementia at the study's beginning. Yet, after the eight-year follow-up, chronic PPI users had a 44% increased risk of dementia compared with those who did not take any medication.
In addition to vitamin B-12, iron and magnesium, researchers found patients who had been taking PPIs over an extended period of time suffered from deficiencies of vitamin C and calcium. This was found to be more of a problem among elderly and malnourished patients than it was among the general population.
You Take PPIs Incorrectly
People often have breakthrough acid reflux symptoms if they do not take their PPIs correctly. Generally, PPIs are most effective if you take them about 30 minutes before your first meal. 1 Food signals your body to secrete stomach acid.
If it has been prescribed for you, you may only take it for a few weeks or months, depending on your condition. Sometimes your doctor may advise you to take it for longer, even many years. Your doctor may suggest taking esomeprazole only when you have symptoms. This means you will not have to take it every day.
Take one Nexium 24HR capsule with a glass of water before eating each morning for 14 consecutive days. Do not take more than one capsule each day. You should not chew the capsule or empty its contents into food or drink.
For many people, prescription NEXIUM can provide 24-hour relief from persistent heartburn pain caused by acid reflux disease. Prescription NEXIUM can also heal possible damage to the esophagus that may be caused over time by acid reflux disease.
People who use Nexium, Prilosec and Prevacid have a 20 to 50 percent higher risk of developing chronic kidney disease. These popular drugs were already linked to short-term kidney problems, but newer studies on Nexium, Prilosec and Prevacid show a link between PPIs and chronic, long-term kidney disease.
Slowly taper off the PPI over 2-4 weeks (the higher the dose, the longer the taper). While the taper is being completed, use the following for bridge therapy to reduce the symptoms of rebound hyperacidity. Encourage regular aerobic exercise. Encourage a relaxation technique such as deep breathing.
Usually, you can stop taking esomeprazole without reducing your dose first. But if you've been taking esomeprazole for a long time speak to your doctor before you stop taking it. Stopping suddenly could make your stomach produce a lot more acid, and make your symptoms come back.
Many over-the-counter medications either block the production of stomach acid or reduce the amount of stomach acid released into your digestive tract. These medications promote the healing of inflammation, some include Prilosec, Nexium, and Zantac.
Although proton pump inhibitors like Nexium are useful in some situations, they can be very difficult to quit. Stopping acid-suppressing drugs suddenly leads to rebound hyperacidity. You may need to reduce your dose even more gradually.