The lesions are often itchy, scaly, and red to purple. The lymphoma might show up as more than one type of lesion and on different parts of the skin (often in areas not exposed to the sun). Some skin lymphomas appear as a rash over some or most of the body (known as erythroderma).
Cytokines can irritate nerve endings in the skin, which can in turn cause persistent itching. Many individuals experience this itchiness in their hands, lower legs or feet, while others feel it throughout their entire body. Patients often report that the itching tends to worsen while they are lying in bed at night.
When lymphoma affects the skin, it may cause a rash that appears as one or more scaly, reddish-to-purple patches, plaques, or nodules. A lymphoma rash, such as mycosis fungoides (MF), can be easy to confuse with other skin conditions, such as psoriasis or eczema, which can cause similar symptoms.
Itching (pruritus) can be a symptom of some types of lymphoma: It is quite common with Hodgkin lymphoma. It is less common with most types of non-Hodgkin lymphoma (other than cutaneous T-cell lymphoma, a type of skin lymphoma).
See your doctor or a skin disease specialist (dermatologist) if the itching: Lasts more than two weeks and doesn't improve with self-care measures. Is severe and distracts you from your daily routines or prevents you from sleeping. Comes on suddenly and can't be easily explained.
Severe intractable itch has been reported in lymphoma patients. Some of the most severe pruritic cases in our practice suffer from lymphoma.
It may also cause a burning sensation. It is not usually associated with an obvious rash unless you have skin lymphoma. Itching can be very difficult to tolerate, especially in hot weather. It is usually worse at night in bed.
Blood tests measure the amounts of certain types of cells and chemicals in the blood. They are not used to diagnose lymphoma, but they can sometimes help determine how advanced the lymphoma is.
However, it's less common in those with non-Hodgkin's lymphoma. Itching can occur without rashes. It's believed that chemicals called cytokines, which are released to fight cancer cells, contribute to making the skin itch.
Swollen lymph nodes, fever, and night sweats are common symptoms of lymphoma. Symptoms of lymphoma often depend on the type you have, what organs are involved, and how advanced your disease is. Some people with lymphoma will experience obvious signs of the disease, while others won't notice any changes.
There are no at-home tests available when it comes to Hodgkin lymphoma.
This disease often goes away without treatment, but it can take anywhere from a few months to many years to go away completely. Lymphomatoid papulosis doesn't spread to internal organs and is not fatal. Rarely, some people with this skin disorder develop another, more serious type of lymphoma.
Immunophenotyping. This laboratory test can detect specific cancer cells based on the types of antigens or proteins on the surface of the cells. Immunophenotyping is used to help diagnose specific types of leukemia and lymphoma.
They can help to reduce itching, but don't work for everyone. Your doctor can prescribe antihistamines. There are many different types and they may give you some relief. They tend not to work so well for itching caused by lymphoma or due to jaundice caused by a blocked bile duct.
Low-Grade Lymphoma
These grow so slowly that patients can live for many years mostly without symptoms, although some may experience pain from an enlarged lymph gland. After five to 10 years, low-grade disorders begin to progress rapidly to become aggressive or high-grade and produce more severe symptoms.
Most types of lymphoma can't be diagnosed by a blood test. However, blood tests can help your medical team find out how lymphoma and its treatment are affecting your body. They can also be used to find out more about your general health.
Stage 1E lymphoma means that the lymphoma started in a single body organ outside the lymphatic system (for example, the liver) and is in only that organ. This is called extranodal lymphoma.
Although Hodgkin lymphoma can start almost anywhere, most often it starts in lymph nodes in the upper part of the body. The most common sites are in the chest, neck, or under the arms. Hodgkin lymphoma most often spreads through the lymph vessels from lymph node to lymph node.
Lymphoma most often spreads to the liver, bone marrow, or lungs. Stage III-IV lymphomas are common, still very treatable, and often curable, depending on the NHL subtype. Stage III and stage IV are now considered a single category because they have the same treatment and prognosis.
Signs and Symptoms
NHL is a disease that usually comes on suddenly and gets worse quickly. Symptoms vary depending on where tumor(s) are. These are the most common locations and their symptoms: Abdomen – pain, swelling, fever, anemia, tiredness, weight loss, vomiting, diarrhea, constipation, and irregular periods.
In most cases, there is no known cause for lymphoma. However, for a few types of lymphoma, scientists have identified a cause: Most cases of gastric MALT lymphoma are caused by a common bacterial infection called Helicobacter pylori. Usually, Helicobacter pylori causes stomach ulcers and indigestion.