Most people with fibromyalgia take a combination of treatments, including FDA-approved drugs like duloxetine (Cymbalta), milnacipran (Savella), and pregabalin (Lyrica), often alongside antidepressants, anti-seizure drugs, exercise, physical therapies (massage, yoga, TENS), and psychotherapy (CBT) to manage widespread pain, fatigue, sleep issues, and mood. Opioids and NSAIDs are generally not recommended for long-term use as they're less effective and carry risks, but doctors might suggest acetaminophen.
Duloxetine (Cymbalta) and milnacipran (Savella) may help ease fibromyalgia pain and fatigue. Your doctor may prescribe amitriptyline or the muscle relaxant cyclobenzaprine to help with pain or sleep. Anti-seizure medicines. Epilepsy medicines often help ease some types of pain.
Milnacipran (brand name: Joncia®) belongs to a class of medicines called serotonin and noradrenaline reuptake inhibitors (SNRI). Other similar drugs from this group are used to treat depression and anxiety, but in Australia milnacipran is approved specifically to treat fibromyalgia.
There are no gold-standard treatments for fibromyalgia. Treatment is focused on symptom management. A multidisciplinary approach and individualized treatment plan that incorporates a combination of interventions can help improve outcomes.
TNX-102 SL (Tonmya; Tonix Pharmaceuticals), cyclobenzaprine HCl sublingual tablets, has been approved by the FDA to treat fibromyalgia in adult patients, making it the first new treatment approved for the musculoskeletal and chronic pain disorder in over 15 years and the fourth treatment approved overall.
Top Vitamins for Fibromyalgia Relief: A Guide to Managing...
On August 15, 2025, the U.S. Food & Drug Administration (FDA) approved a new treatment: Tonmya (cyclobenzaprine HCl sublingual tablets), marking the first new FDA-approved drug for fibromyalgia in more than 15 years.
Experts don't know what causes fibromyalgia, but studies have found that certain health conditions, stress and other changes in your life might trigger it. You might be more likely to develop fibromyalgia if one of your biological parents has it.
Küçük et al15 compared 58 women with fibromyalgia with a control group of women without fibromyalgia and noted that the vitamin D, B12, and ferritin levels were lower in the patients with fibromyalgia than in the control group and that there was a negative correlation between the number of tender points and these ...
Lab Tests for Fibromyalgia
6 ways to manage your fibromyalgia
Financial help for fibromyalgia comes in two main forms in Australia. Disability Support Pensions and TPD insurance claims from your super policy can each give you assistance. It's possible to qualify for both!
What is the best muscle relaxer for fibromyalgia? Cyclobenzaprine (Flexeril) is the most studied muscle relaxer for fibromyalgia, with research showing it can help with pain, sleep, and muscle tension. Tizanidine (Zanaflex) is another option that may reduce substance P levels and improve sleep when taken at bedtime.
PRP injections
Perhaps one of the most advanced fibromyalgia treatments is platelet-rich plasma (PRP) injection therapy. The injection is a concentration of platelets extracted from a sample of your own blood. Platelets are your body's natural healers.
Stage 4: Severe and Debilitating Symptoms
The final stage of fibromyalgia is marked by severe and debilitating symptoms. Pain can become overwhelming, and fatigue may prevent patients from engaging in even the simplest tasks.
Researchers think that fibromyalgia affects the way the brain and spinal cord process painful and nonpainful signals. That increases your overall sensitivity to pain. Symptoms often start after a triggering event. Triggers can include injuries, surgery, infections or emotional stress.
The pain most often affects the muscles and the points where muscles attach to bones. These are the ligaments and tendons. Pain may start in one part of your body, such as your neck and shoulders. But any part of the body may be affected.
Foods to Eat With Fibromyalgia
Eating lots of fruits and vegetables can improve the health of a fibromyalgia patient. Fruits and vegetables are low in calories and high in fiber and antioxidants. Vitamins A, C, and E are found in fresh fruits and veggies, and these also fight free radicals to keep your body normalized.
There are 18 tender points that exists as nine symmetrical pairs (left and right), located at the:
It's also suggested that some people are more likely to develop fibromyalgia because of genes inherited from their parents. In many cases, the condition appears to be triggered by things that are physical or emotional like an injury, an infection or stress.
Toothaches in those with fibromyalgia aren't always due to typical dental issues such as cavities or gum disease. Instead, fibromyalgia can cause orofacial pain that is unrelated to these common dental problems1.
While there's no known cure, many people find relief through a combination of medical care and natural approaches. In fact, several home remedies for fibromyalgia are gaining popularity among patients seeking safer, more holistic ways to manage their symptoms.
If you're living with fibromyalgia, you already know that there is no cure for the pain and fatigue you often feel. Fortunately, with medications, self-care strategies and lifestyle modifications, living with fibromyalgia can be a little easier.
In general, TENS unit placement for fibromyalgia (example here) features two electrodes on either side of the spine just at the tops of the shoulder blades, with another two on either side of the lower back. This placement targets widespread nerve pain that is characteristic of fibromyalgia.