Leukemia. Lymphoma. Bone marrow disorders such as polycythemia vera or myelofibrosis.
Acute or chronic significant leukocytosis above 25x10^9/mL, however, can have severe complications and potentially be fatal. WBC counts 25x10^9/mL and above can cause a hyperviscosity type syndrome, which can be seen in leukemia, lymphoma, and myeloproliferative disorders.
White Blood Cells, Abnormalities of - 120
White blood cell (neutrophil and lymphocyte) abnormalities include abnormalities of number (leukocytosis or leukopenia) and of function. Leukocystosis and leucopenia may occasionnaly indicate serious and potentially urgent medical problems.
Many solid tumors, such as lung, ovary, gallbladder, kidney, colon, and stomach carcinomas, produce various cytokines, especially G-CSF, GM-CSF, IL-1, and IL-6, leading to WBC elevation especially of neutrophils. This excessive leukocytosis is also referred to as LPR.
Cancer. Some tumors such as bladder, prostate or kidney tumors can generate leukocytes in the urine. These situations cause the immune system to weaken. It may also be the case that leukocytes appear as a consequence of the treatment performed against these tumors.
Leukocytosis is often the initial finding that leads to the diagnosis of a primary hemato- logic disorder, such as leukemia or a myeloproliferative neoplasm.
Disorders related to having a high white blood count include: Autoimmune and inflammatory diseases, conditions that cause the immune system to attack healthy tissues. Bacterial or viral infections. Cancers such as leukemia and Hodgkin disease.
If your doctor tests your urine and finds too many leukocytes, it could be a sign of infection. Leukocytes are white blood cells that help your body fight germs. When you have more of these than usual in your urine, it's often a sign of a problem somewhere in your urinary tract.
Neutrophils (also called polys, segs, or polymorphonuclear leukocytes) are the most common, making up about 50% to 60% of the total WBCs.
The differential diagnosis of leukocytosis includes physiologic responses to a broad range of infectious and inflammatory processes, as well as numerous primary hematologic disorders such as leukemias, lymphomas, and myeloproliferative neoplasms.
Leukocytosis is a high number of white blood cells. It can occur as a normal response to infections, injuries, and illness as the body is healing. In these situations, the symptoms can include a fever, chills, sweating, or fatigue, and will usually go away once the illness resolves.
Leukocyte esterase is a screening test used to detect a substance that suggests there are white blood cells in the urine. This may mean you have a urinary tract infection. If this test is positive, the urine should be examined under a microscope for white blood cells and other signs that point to an infection.
Total leukocyte count increases significantly in response to infection, trauma, inflammation, and certain diseases.
Non-cancerous blood disorders include aplastic anaemia, sickle cell disease, thalassaemia and autoimmune diseases.
Septic shock may cause either leukocytosis or leukopenia. Many septic patients exist between these two extremes, with a normal WBC (such patients often develop leukocytosis in a delayed fashion).
Among the most common medications causing leukocytosis are corticosteroids, lithium, and β-agonists. Also implicated are recombinant cytokines, antihypertensives, antifungals, antibiotics, anticonvulsants, antidiabetics, antidepressants, and others.
Leukapheresis is a way of removing abnormal white blood cells from the blood. You might have this treatment if you have a very high white blood cell count. Very high numbers of leukaemia cells in the blood can cause problems with normal circulation.
An increase in the number of circulating leukocytes is rarely due to an increase in all five types of leukocytes. When this occurs, it is most often due to dehydration and hemoconcentration.
Leukocytosis (WBC > 10,000/mm 3) can indicate infection, inflammation (possibly from allergies), tissue damage or burns, dehydration, thyroid storm, leukemia, stress, or steroid use. The degree of leukocytosis depends on the severity of the disorder, the patient's age and general health, and bone marrow health.
A high number of leukocytes can indicate a person has kidney stones. Kidney stones can travel to the urinary tract and can disrupt the flow of urine. Blockages here can cause an increase in leukocyte production and leukocytes passing into the urine.
In some cases, leukocytes can be found in a urine sample without actually having a urinary tract infection, which may be due to an incorrect technique or bad hygiene when collecting the sample. This is highly suspected if there are no nitrites present in the urine at the time.
We concluded from the above study that percentage of normal individuals having leukocytes in their urine is greater than happy individuals. So, there is a connection between normal individuals and anxiety level [1].
The term leukemia means white blood. White blood cells (leukocytes) are used by the body to fight infections and other foreign substances. Leukocytes are made in the bone marrow. Leukemia leads to an uncontrolled increase in the number of white blood cells.