There are many causes of
Antiseizure Medications -- Taking antiseizure or anticonvulsant medications for a long time can lower biotin levels in the body. Valproic acid can cause biotinidase deficiency, which may improve with biotin supplements. Ask your doctor before taking any supplements, however.
Symptoms of biotin deficiency start gradually and can build up over time. Symptoms can include thinning hair, progressing to loss of hair across the body, and a scaly, red rash around body openings, including the eyes, nose, mouth, and anus. Conjunctivitis can also develop.
Egg white contains a protein called avidin, which binds to biotin extremely tightly, though not via a covalent linkage. The physiological function of the avidin in egg white is not clear. The protein tightly binds the biotin released during the digestion of dietary protein and prevents its absorption.
Biotin deficiency can cause thinning hair and loss of body hair; a rash around the eyes, nose, mouth, and anal area; pinkeye; high levels of acid in the blood and urine; seizures; skin infection; brittle nails; and nervous system disorders.
How long does it take to recover? A high dose of biotin supplement will take 3-5 days to treat the symptoms of biotinidase deficiency, and will most likely disappear in 3-5 months.
To maximize the intake of biotin and for safety reasons, always cook eggs before eating them. Raw egg white contains a protein called dietary avidin, which binds to biotin and makes it harder for the body to absorb it. Cooking separates the biotin from the avidin, helping the digestive tract to absorb the vitamin.
Most commonly, biotin use can result in falsely high levels of T4 and T3 and falsely low levels of TSH, leading to either a wrong diagnosis of hyperthyroidism or that the thyroid hormone dose is too high.
“Consuming beverages with caffeine inhibits the absorption of water-soluble vitamins like vitamin C, biotin and the seven B vitamins.”
There are reports that excessive biotin supplementation can lead to insomnia. Since biotin supplements are needed to metabolize fats and carbohydrates and turn these into energy, excessive intake of biotin during nighttime might lead to a surge of energy. This surge of energy may make it difficult for you to sleep.
With early detection and biotin therapy, many of the symptoms and signs of biotin deficiency are reversible. However, if left untreated, vision problems, hearing loss, and developmental delay can occur and these are usually irreversible.
All these neurotransmitters are needed to maintain a healthy mood and prevent depression and anxiety. These neurotransmitters also relax the brain and allow for better cognition and memory. Biotin deficiency can lead to symptoms of depression and anxiety.
Egg white contains an anti-nutrient called avidin. Avidin binds to the B vitamin biotin, preventing its absorption.
Biotin has no effect on thyroid hormone levels or thyroid function in the body. However, biotin can interfere with the measurement of hormone levels in the laboratory, making them inaccurate.
Biotin, also called vitamin B7, vitamin H and Coenzyme R, is a nutrient that the body requires in small amounts (micronutrient). It is a coenzyme that is necessary for fat, protein, and carbohydrate metabolism—it helps turn the food you eat into energy. It also has a role in hormone production.
Altogether, these data demonstrate that biotin deficiency enhances the secretion of TNF-α, IL-1β, IL-23, and IL-12p40 from DCs, which biases the Th cell responses towards Th1/Th17. Biotin deficiency thus favors inflammation since these are all highly proinflammatory responses.
When testing vitamin D levels using these immunoassays, biotin interference can cause a falsely high result. This has been known to create confusion for participants when testing their vitamin D levels through GrassrootsHealth and another lab (such as through their doctor) around the same time.
6. Biotin (Vitamin B7) The brain is particularly sensitive to the delivery and metabolism of glucose. Biotin plays a key role in glucose metabolism and haemostasis, including regulation of hepatic glucose uptake, gluconeogenesis (and lipogenesis), insulin receptor transcription and pancreatic β-cell function [18].
Worldwide profound biotinidase deficiency is reported to be 1 in 137401; partial biotinidase deficiency is estimated to be 1 in 109,921, and the comprehensive incidence is 1 in 61067.
Most biotin in food is protein bound and must be released prior to intestinal absorption. Biotin is water soluble and as a result free biotin is absorbed almost 100%. Almost 50% of ingested biotin is excreted unchanged in urine.
Sources of Biotin
Other foods that contain this vitamin are whole meal bread, salmon, pork, sardines, mushroom and cauliflower. Fruits that contain biotin include avocados, bananas and raspberries. In general, a healthy varied diet provides the body with sufficient amounts of biotin.
Regular intake of excessive quantities of certain nutrients can cause hair loss in some cases due to a temporary condition known as Telogen Effluvium. However, the effects of too much vitamin B7 - also known as biotin toxicity - remain unconfirmed.
There is no specific antidote for overdosing on biotin. Excess in the body is rare, and since biotin is a water-soluble vitamin, it is excreted in the urine when in excess. Signs and symptoms of biotin overdose may include and are not limited to insomnia, excessive thirst, and urination.
Biotinidase deficiency (BD) is a rare, autosomal recessively inherited disorder that if untreated can cause neurologic symptoms including seizures, hypotonia, respiratory abnormalities, and vision/hearing loss, especially in countries that do not screen newborns.