Besides the role of inflammation, HLA B27 has been associated with increased risk of malignancies such as lymphoma and colorectal cancer [6, 7].
HLA-B27 and Ankylosing Spondylitis
One gene, HLA-B27, is strongly associated with a big family of rheumatic diseases called spondyloarthropathies. It includes: Axial spondyloarthritis.
Advanced Ankylosing Spondylitis
If you have more advanced AS, your doctor may tell you that your spine has fused. That happens when new bone grows between some of the small bones that form your spine, joining them together. The more this happens, the less movement you have in your spine.
Life expectancy for people with ankylosing spondylitis is the same as that of the general population, except for patients with severe symptoms and complications. Ankylosing spondylitis is a chronic, inflammatory autoimmune disease.
In severe, advanced cases of ankylosing spondylitis there is a complete fusion of the bones of the spine, turning the spinal column into one long bone, which some people say resembles a bamboo stalk. It is quite rare for complete spinal fusion to occur in patients receiving treatment.
Ankylosing spondylitis has no known specific cause, though genetic factors seem to be involved. In particular, people who have a gene called HLA-B27 are at a greatly increased risk of developing ankylosing spondylitis. However, only some people with the gene develop the condition.
Spondylosis can lead to spinal stenosis, which is a narrowing of the spinal canal. As a result, the spinal cord and/or spinal nerve roots can become compressed (pinched). For example, the cervical spinal cord can be affected by compression from spondylosis. This is called cervical spondylotic myelopathy.
Ankylosing spondylitis may affect more than the spine. The disease may inflame joints in the pelvis, shoulders, hips and knees, and between the spine and ribs.
"B27 disease" is a new autoimmune disease that afflicts millions of people throughout the world. "B27 disease" occurs in individuals who have ankylosing spondylitis (AS) or preankylosing spondylitis and/or uveitis and are also positive for HLA-B27.
Ankylosing spondylitis (AS) is a chronic, inflammatory disease of the axial spine that can manifest with various clinical signs and symptoms. Chronic back pain and progressive spinal stiffness are the most common features of the disease.
With lower frequency, the presence of the HLA-B27 allele has correlated with inflammatory bowel disease, psoriatic arthritis, and reactive arthritis.
AS can run in families, and the HLA-B27 gene variant can be inherited from another family member. If you have AS and tests show you carry the HLA-B27 gene variant then there is a 1 in 2 chance that you could pass on the gene variant to any children you have.
HLA-B27 positive Caucasians have a 20-fold risk of developing any spondylarthropathy, particularly ankylosing spondylitis and undifferentiated spondarthritis. Family and twin studies of ankylosing spondylitis have shown a polygenic pattern of genetic susceptibility with heritability in excess of 90%.
Ankylosing spondylitis is caused by Klebsiella.
"Fatigue from inflammation in ankylosing spondylitis can feel like you have the flu. You can ache all over," says Rochelle Rosian, MD, the director of regional rheumatology at the Cleveland Clinic in Ohio. “That's because inflammation affects your whole body, not just your joints.”
Ankylosing spondylitis (AS) is a type of arthritis. It causes pain and stiffness, mainly in your spine. But it can also cause eye inflammation called uveitis. Left untreated, uveitis can harm your vision and, in some cases, lead to blindness.
It is a rare disease, there is no cure, and you will end up in a wheelchair.
While people with ankylosing spondylitis taking biologic medications might be at an increased risk of infections, there is no evidence at this time that suggests that patients with ankylosing spondylitis are at an increased risk of acquiring COVID-19 or having more severe symptoms if they do get sick.
If you have ankylosing spondylitis, you may have pain and stiffness at night, in the morning, or when you're not active. The pain may begin in the joints between your pelvis and spine and then move along your spine. Your pain may get better with movement or exercise.
Second Stage AS
As ankylosing spondylitis symptoms worsen (increased pain and stiffness), the disease may start to involve other parts of the body. For example, systemic inflammation can affect the eyes and your vision could become impacted.