Since antigens play a major role in how lupus works, studies checked if the blood groups with antigens (A, B, and AB) are a risk factor. One study⁸ demonstrated that people with B+ blood type might have a higher risk of developing lupus.
Of the eight main blood types, people with Type O have the lowest risk for heart attacks and blood clots in the legs and lungs. This may be because people with other blood types have higher levels of certain clotting factors, which are proteins that cause blood to coagulate (solidify).
We showed that blood type changed from A to AB in a female patient with SLE, and that her blood type returned to A after steroid pulse therapy.
Results: This study projected that in lupus patients, Coombs-positive autoimmune hemolytic anemia and arthritis were more common among the B blood type and Rh-positive group, respectively.
Women of all ages are affected far more than men (estimates range from 4 to 12 women for every 1 man). Learn more about lupus in women. Minority racial and ethnic groups—blacks/African Americans, Hispanics/Latinos, Asians, and American Indians/Alaska Natives—are affected more than whites/Caucasians.
While Shimizu and Colleagues10 found that blood type B was associated with longevity, Mengoli and Colleagues6 and Brecher and Hay12 concluded that group B was inversely correlated with age. In addition, there are isolated reports of group A7 and group O9 being associated with longevity.
Blood type and stress
Type A may exhibit more anxious behaviour than other types. The blood types B and AB have been found to respond better to stress. And blood type O was found to have the lowest amounts of cortisol in their bodies.
Recent data suggests that people with blood type A have a significantly higher risk of acquiring COVID-19 than non-A blood types. Blood type O seems to have the lowest risk. Yet these risks are relative, meaning people with type O blood are not immune to COVID-19.
Type O negative red blood cells are considered the safest to give to anyone in a life-threatening emergency or when there's a limited supply of the exact matching blood type. That's because type O negative blood cells don't have antibodies to A, B or Rh antigens.
Donors with blood type O... can donate to recipients with blood types A, B, AB and O (O is the universal donor: donors with O blood are compatible with any other blood type)
The most potent risk factor in the development of systemic lupus erythematosus is gender; females are more likely to develop SLE.
What are some triggers for lupus flares? Common triggers include: Overwork and not enough rest. Being out in the sun or having close exposure to fluorescent or halogen light.
Hydrochloric Acid and Blood Type
Specifically, Type O's tend to have higher stomach acid than other types, while Type A's tend to have lower stomach acid than other types.
The risk of ADHD is increased in the presence of alleles O and A, but the risk is reduced in the presence of allele B.
The ABO gene is connected with brain function and memory loss. People who have blood types A, B, and AB are up to 82 percent more likely to develop cognition and memory problems — which can lead to dementia — compared to those with Type O.
Blood Type A Is Linked to Stress
People with blood type A are prone to having more cortisol in their bodies—and therefore at a higher risk of stress. "If you have type A blood, you may have more trouble handling stress," says Glenn E. Ramsey, MD, Northwestern Medical Group, Pathology.
Here's one finding that has continued to surface over the years: People with a non-O blood type (that's A, B, or AB) are at a higher risk of developing cardiovascular diseases.
Type O is routinely in short supply and in high demand by hospitals – both because it is the most common blood type and because type O negative blood is the universal blood type needed for emergency transfusions and for immune deficient infants.
In molecular history, type A appears to be the 'oldest' blood type, in the sense that the mutations that gave rise to types O and B appear to stem from it. Geneticists call this the wild-type or ancestral allele.
Kidneys About one half of people with lupus experience kidney involvement, and the kidney has become the most extensively studied organ affected by lupus. Lungs About 50% of people with SLE will experience lung involvement during the course of their disease.