Pernicious anemia is a relatively rare autoimmune disorder that causes diminishment in dietary vitamin B12 (cobalamin) absorption, resulting in B12 deficiency and subsequent
Since your body doesn't make vitamin B12, you have to get it from the foods you eat or from supplements. You can get vitamin B12 deficiency if you can't absorb vitamin B12 due to problems with your gut or if you have pernicious anemia, which makes it difficult to absorb vitamin B12 from your intestines.
Pernicious anemia, one of the causes of vitamin B12 deficiency, is an autoimmune condition that prevents your body from absorbing vitamin B12.
Pernicious anemia is a relatively rare autoimmune disorder that causes diminishment in dietary vitamin B12 (cobalamin) absorption, resulting in B12 deficiency and subsequent megaloblastic anemia. It affects people of all ages worldwide, particularly those over 60.
B12 deficiency manifests as macrocytic anemia, and thus, the presenting symptoms often include signs of anemia, such as fatigue and pallor. Due to the increased hemolysis caused by impaired red blood cell formation, jaundice may also be a presenting symptom. Therefore, a thorough dermatologic exam may also be helpful.
[1] People who regularly take medications that suppress stomach acid for conditions like gastroesophageal reflux disease (GERD) or peptic ulcer disease—such as proton-pump inhibitors, H2 blockers, or other antacids—may have difficulty absorbing vitamin B12 from food.
If your anemia goes untreated for a long time, it can lead to heart failure. That's because your heart has to work harder. B12-related anemia may also raise the chances you'll have a heart attack, stroke, or other cardiovascular problem.
Although it's uncommon, vitamin B12 or folate deficiency (with or without anaemia) can lead to complications, particularly if you've been deficient in vitamin B12 or folate for some time. Potential complications can include: problems with the nervous system. temporary infertility.
Vitamin B12 deficiency can indeed lead to weight gain. But the weight gain is not a direct result of the deficiency. Instead, vitamin B12 deficiency causes lethargy or lack of energy, and in turn, inactivity causes weight gain. When you lack the energy to move, you don't burn fat.
Stage 1 is decreased levels of vitamin B12 in the blood. Stage 2 is low concentration of vitamin B12 in the cell and metabolic abnormalities. Stage 3 is increased levels of homocysteine and MMA and decreased DNA synthesis resulting in neuropsychiatric symptoms. Stage 4 is macrocytic anemia.
There are certain foods that also need a cut-down in case of vitamin B12 deficiency. “Some foods and drinks can interfere with vitamin B complex intake like alcohol, caffeine and processed foods, etc should be avoided completely,” Shah added.
Disturbed or blurred vision can also occur as a result of a Vitamin B12 deficiency. This happens when the deficiency causes damage to the optic nerve that leads to your eyes. The nervous signal that travels from the eye to the brain is disturbed due to this damage, leading to impaired vision.
The most common way to treat B12 deficiencies is by adjusting your diet. If this is unsuccessful, vitamin supplements may be recommended. If you're looking to boost the amount of vitamin B12 in your diet, you should eat more animal products, like meat, seafood, dairy and eggs.
Can I take magnesium and vitamin B together? Yes, as B vitamins and magnesium don't compete for absorption inside your body. Indeed, many supplements combine them as a way of simplifying how you monitor your intake.
If you have a vitamin B12 deficiency, it can take months—even a year—to correct it. Vitamin B12 deficiency is common, especially among vegetarians and older adults. Also known as cobalamin , it is a water-soluble vitamin found in meat, fish, and dairy. Vitamin B12 is essential for brain and nerve function.
One of the best drinks with B12 is milk. One cup of whole milk contains approximately 1.32µg of vitamin B12.
Apples Aside from being an important inclusion in a list of vitamin B12 fruits, apples are also rich in fibre, antioxidants, and flavonoids. Apples also comprise polyphenols that are found in both the peel and the pulp of the nutrient-dense fruit.
So why does vitamin B12 deficiency particularly affect older adults? As people get older, their ability to absorb vitamin B12 decreases. This is because aging adults often develop problems with the acids and stomach enzymes needed to process the vitamin.
B12 is required as a cofactor by gut microbes for various biological processes, including acetate production via the Wood-Ljungdahl pathway, and for the conversion of succinate to propionate.
Vitamin B1 (Thiamine)
Vitamin B1 deficiency can cause heavy and tired legs after running, muscle cramps, fatigue, and odd sensations in your legs and feet. Some foods rich in vitamin B1 include whole grains, vegetables, legumes, milk products, and meat.
B12 also plays a role in the production of melatonin, a hormone that helps regulate our circadian rhythms. It is possible that a deficiency of B12 could lead to disrupted sleep patterns.
Stress is known to deplete our levels of B vitamins, especially vitamin B12. Vegetarians, vegans and those on restricted diets can struggle to get enough vitamin B12 to meet their body's needs.