The biggest recent breakthrough in bronchiectasis treatment is the FDA approval of brensocatib (Brinsupri™), the first targeted anti-inflammatory drug for non-cystic fibrosis bronchiectasis (NCFB) that reduces exacerbations by blocking DPP-1 enzymes, offering a shift from symptom management to disease modification. Other emerging approaches involve new DPP-1 inhibitors (like BI1291583), dual PDE3/PDE4 inhibitors (ensifentrine for COPD but under investigation for bronchiectasis), and monoclonal antibodies targeting specific inflammatory pathways (IL-4, IL-5, IL-13) for certain patient groups, alongside ongoing research into personalized medicine and existing drugs like statins.
In August 2025, the FDA approved Brensocati, a selective dipeptidyl peptidase-1 (DPP-1) inhibitor, as the first disease-modifying therapy for bronchiectasis. By blocking NSP activation, Brensocatib reduces inflammation and exacerbation.
The most common causes of flare ups are infections. Bacteria are most common but they can be caused by viruses or a combination of both. As mentioned before some people have bugs colonising their lungs which can cause more frequent flare ups, this is particularly true if you have pseudomonas in your lungs.
A ground-breaking discovery
However, Professor Chalmers has discovered the world's first tailored therapy for bronchiectasis - a new drug called brensocatib. The drug was tested on people living with bronchiectasis and showed it can make a real improvement to their lung health, reducing inflammation and flare-ups.
BRINSUPRI™ (brensocatib) is a small molecule, once-daily, oral, reversible inhibitor of dipeptidyl peptidase 1 (DPP1) indicated for the treatment of non-cystic fibrosis bronchiectasis (NCFB) in adult and pediatric patients 12 years of age or older.
Antibiotics are the most common treatment for bronchiectasis. Oral and sometimes inhaled antibiotics are used to treat most infections. An infection that does not get better with oral antibiotics may require intravenous (IV) antibiotics.
At $88,000 per year, the launch price for brensocatib is substantially higher than a cost-effective price.
Antioxidants (vitamins A, C, E, selenium) seem beneficial in reducing oxidative stress, which is elevated in bronchiectasis. Adequate calcium for bone health. Omega-3 fatty acids may help via anti-inflammatory effects.
CHICAGO, Dec. 19, 2025 — Today, the U.S. Food and Drug Administration approved Boehringer Ingelheim's nerandomilast (Jascayd) for the treatment of progressive pulmonary fibrosis (PPF) in adults.
What treatments are used for bronchiectasis?
If you are suffering from bronchiectasis, you should consider Salt Therapy. Not only will it bring much-needed relief, but it also prevents the frequency of symptoms occurring. Salt Therapy is a clinically proven natural, safe and beneficial method of treatment for every age group.
Coughing up mucus is a common symptom.
The most common symptom of bronchiectasis is a chronic cough that produces a lot of mucus. Other signs and symptoms include: Shortness of breath. Chest congestion.
If supplemental oxygen is used, it is appropriate to maintain a saturation of >92%. The addition of oxygen therapy to a patient's management plan should be determined by a comprehensive clinical assessment, not just the requirement of an increase in PaO2.
Currently, bronchiectasis has no cure. However, most people can enjoy a good quality of life and manage the condition with stepwise treatment , including clearing their lungs, exercising, and taking steps to lower the chance of lung infection.
Anti-Inflammatories for Lung Conditions
Sugary and Carbonated Beverages.
Consuming large amounts of soda and energy drinks, especially those with caffeine or lots of sugar, can lead to rapid breathing and an increased heart rate. A diet high in sugar can also increase the risk of infections, which people with bronchiectasis are more susceptible to.
Nerandomilast is used to treat idiopathic pulmonary fibrosis (IPF; scarring of the lungs with an unknown cause). Nerandomilast is in a class of medications called phosphodiesterase 4 (PDE4) inhibitors. It works by blocking the action of a certain natural substance in the body that is involved in causing fibrosis.
The company confirmed the list price of Jascayd at $16,219 per month.
PEOPLE HAVE BEEN PRESCRIBED SAPHNELO FOR SLE IN THE US SINCE 2021. SAPHNELO IS THE #1 PRESCRIBED BRAND FOR ADULT PATIENTS WITH LUPUS WHO ARE STARTING A NEW IV BIOLOGIC.
Vitamin D deficiency was found in the majority of patients with bronchiectasis despite sufficient sun exposure. Vitamin D levels correlated with extension and severity of bronchiectasis, and with lung function decline. These correlations were stronger than those found for other inflammatory markers.
Research suggests that vitamin D enhances lung function and increases exercise duration. In a study involving over 10,000 adults in South Korea, vitamin D supplementation improved lung capacity and eased breathing in patients with tuberculosis.
Ascorbic acid, also known as vitamin C, is a powerful antioxidant. Antioxidants help address cellular wear and tear that can set off inflammation. You'll find vitamin C in fruits and vegetables, which are the basis of a healthy diet.
Brensocatib is used to treat non-cystic fibrosis bronchiectasis (NCFB; a lung condition caused by inflamed and damaged airways). Brensocatib is in a class of medications called dipeptidyl peptidase 1 (DPP1) inhibitors. It works by decreasing inflammation and improving lung function.
Medicines for bronchiectasis
Your care team will give you instructions on when to take them. If you get more than 3 chest infections a year, a specialist may recommend you take antibiotics long term to help prevent them. You may also be offered other medicines, such as inhalers to help your breathing.
Our pulmonologists, or lung specialists, have expertise in the direct delivery of antibiotics to the lungs. They also have experience managing rare but serious conditions, such as atypical mycobacterial infections, that are known to affect people with bronchiectasis.