Dupuytren's disease is thought to be a hereditary disorder, running in families; however, the exact cause is unknown. There are a number of other risk factors that are believed to contribute to developing Dupuytren's disease. These include: Gender: Men are 8x more likely to develop the condition than women.
The cause of Dupuytren contracture is unknown. The condition tends to run in families. It's more common in men than in women.
Dupuytren's contracture is believed to run in families (be hereditary). The exact cause is not known. It may be linked to cigarette smoking, alcoholism, diabetes, nutritional deficiencies, or medicines used to treat seizures.
Dupuytren's disease is common in Norway and northern Europe but rare in individuals who are not of European descent. The aboriginal Sami of the northernmost parts of Scandinavia are ethnically distinct from most Norwegians.
In all analyses, no evidence was found for an excess of Norse ancestry in Dupuytren's disease. We conclude that there is no genetic evidence for a 'Viking origin of Dupuytren's disease'.
Through DNA testing, it is possible to effectively trace your potential inner Viking and discover whether it forms part of your genetic makeup or not. However, it's not 100% definitive. There's no exact Nordic or Viking gene that is passed down through the generations.
It sometimes was erroneously called "Viking disease," since it was often recorded among those of Nordic descent. In Norway, about 30% of men over 60 years old have the condition, while in the United States about 5% of people are affected at some point in time.
Dupuytren's contracture: This form of arthritis causes the tissue beneath the hand to develop nodules in the fingers and palms. These lumps can cause the fingers to stick in place.
Both alcohol and smoking are frequently mentioned as risk factors for Dupuytren's contracture. “The evidence for smoking is stronger than for drinking, and it makes sense because smoking, like diabetes, decreases blood supply to the hand,” Evans says.
Dupuytren disease is a genetic disorder that often is inherited in an autosomal dominant fashion, but is most frequently seen with a multifactorial etiology. It is associated with diabetes, seizure disorders, smoking, alcoholism, HIV, and vascular disease.
This condition usually progresses slowly over years or even decades. However, there's not enough research to determine the average span for the progression of Dupuytren's contracture. Most who develop it are men over age 50.
Dupuytren often runs in families but can skip several generations. One-fourth of Dupuytren patients don't know anyone in their family with it.
In ages 41 to 50 years there was no apparent increase among alcoholics when compared to nonalcoholic controls of the same age. However, in ages 51 to 60 years Dupuytren's contracture was significantly increased in alcoholics when compared to controls.
Dupuytren's contracture can be considered a complication of diabetes and of the local neurovascular changes since both are often associated. The contracture is usually not severe in diabetes, is nodular in form, and usually crushes the palmar surface of the long and ring fingers.
Dupuytren disease is also associated with diabetes, hyperlipidemia, a variety of other medical conditions, increased cancer risk and shortened lifespan.
Magnesium isn't necessarily a cure. Instead, low magnesium levels may be the culprit. Low magnesium levels may act as a stressor, amplifying the effect of calcium on Dupuytren biology.
Dupuytren's contracture complications
If left untreated, Dupuytren's contracture can be debilitating. As the condition progresses, it can limit your ability to open your hand fully, grasp small objects, or insert your hands in narrow spaces.
Soft-tissue manipulation and massage can be especially beneficial during the early stages of Dupuytren's contracture. Due to the fact that this is often a progressive condition, there's simply no reason to wait to see if “it gets better” before booking an appointment with a chiropractor to try to manage symptoms.
We observed a tendency toward changed frequencies of occurrence of central nervous system tumors, laryngeal cancer and non-melanoma skin cancers in DD families. The results of our study indicate a lack of a strong association between Dupuytren disease and familial cancer risk.
In terms of the immunological features of DD, evidence has persistently suggested the involvement of both T and B lymphocytes in DD etiology [7, 38]. As such, the disease has frequently been termed a “T-cell-mediated autoimmune disorder” [6].
Dupuytren's contracture mainly affects the ring and little fingers. You can have it in both hands at the same time. It tends to get slowly worse over many months or years.
You may be able to get Industrial Injuries Disablement Benefit if you have Dupuytren's contracture caused by your work. Dupuytren's contracture is a condition where, over time, one or more fingers permanently bend in towards the palm of your hand and can no longer be straightened.
Viking DNA study finds they were more genetically diverse than modern Scandinavians. The Viking Age brought surprising genetic diversity to northern Europe, but it didn't last.
Who are the descendants of the Vikings? Viking settlements exist in different parts of the world, including Denmark, Greenland, Iceland, Great Britain, Ireland, Scotland, Normandy and Swedish parts of Finland, Estonia and Latvia.