Deadpool is effectively immortal, although he has died several times. He is still alive 800 years in the future when the new X-Force encounters him.
Immortality: Deadpool's healing factor provides him with an endless lifespan by halting the aging process. His life span is extended to such a degree that an alternate reality version of him was alive and still in business as Deadpool 800 years in the future.
So, can Deadpool die? The answer is yes, but it's not as simple as it seems. While there are ways to kill him permanently, his healing factor makes him incredibly resilient, and his ability to come back from even the most impossible deaths is a testament to his immortality.
Deadpool's immortality lies in his cancer and regeneration ability. According to the comics, cancer triggered his healing powers. As a result, the cancerous cells regenerate just like the normal, healthy ones do.
And because of his healing factor, Wade ages really slowly, making it almost impossible to guess how old he is. We also know he can live at least 800 years, as we have seen in the alternate future of Deadpool of Earth-80521, where he was stuck beneath a collapsed building during all those years (in the storyline).
Deadpool is effectively immortal, although he has died several times. He is still alive 800 years in the future when the new X-Force encounters him. In addition, Thanos once declared that Deadpool should "consider yourself cursed ... with life!" out of jealousy over Deadpool's status as Death's love interest.
Disease Immunity: The unique regenerative qualities of Deadpool's healing factor also extend to his immune system; he is immune to all diseases, infections, disorders, imperfection, and resistant to elemental extremes.
Well, he didn't do it himself. The nefarious sorcerer T-Ray (who has his own bones to pick with Wade Wilson) cursed Deadpool using a cosmic artifact given to him by Thanos. As a result, Deadpool was unable to die, which prevented him from joining his lover in the afterlife.
His cancer is never cured. That's one of the defining characteristics of Deadpool, and why he looks the way he does. His healing factor affects not only his normal, healthy cells, but his cancerous ones too, making them unable to die.
Again, the implications of this are still a mystery, even to Deadpool. This caused Thanos, who was in love with Mistress Death, to curse Deadpool with immortality. Death's design in the video game.
Deadpool is nigh-immortal, meaning the situation has to be insanely specific for him to die. He does feel pain, however, and he feels it all the time – both physically, and mentally. He's just learned to ignore it. As for aging, Deadpool's healing factor makes it so slow it's practically non-existent.
Deadpool can survive a nuclear bomb -- how hard could it be, right? The merc has been known for being indestructible, but you would have never guessed that he could survive his very atoms being blown to bits.
Cows, Clowns and Other Phobias
The fast-talking gunman seems almost fearless on the battlefield, but in reality, there's a lot that scares the Merc with the Mouth. There are two things though, that scare him above all: cows and clowns are a Deadpool weakness.
Deadpool creator Rob LiefeldOpens in new tab says that Wade Wilson can even regrow his entire head if he had to.
At the start of the game you can make Deadpool drink loads of beer, however Deadpool scolds the player for it and states he can't get drunk even if he wanted too.
Deadpool is also able to regenerate limbs even faster, consciously control his healing, and - best of all - whatever he regrows actually comes back better than when it was damaged. It's suggested Wade's regenerated limbs are stronger and more durable, and could even deflect bullets.
Would Deadpool survive if he was thrown in lava? Yes, Deadpool could escape; he's capable of regenerating from a single cell and survived getting his head uppercutted by the Hulk, splitting his head into sub-atomic particles.
Deadpool has died many times, and being hurled into the sun would definitely end up being one of those times. Direct immersion in the Sun would kill nearly any protagonist in the MCU short of Ghost Rider and maybe the Silver Surfer.
A black hole is an area in spacetime which gravity is so strong that not even light can't escape. Moments after crossing the event horizon, tidal forces on the black hole causes whatever falls in (whether it's Deadpool, you, or a piece of chimichangas) to get stretched until it breaks, and that is how you die.
While Thanos ranks far from the top 10 villains in the Marvel Universe, The Mad Titan is powerful enough to effortlessly put down Deadpool. Given the latter ever fights Thanos with Infinity Gauntlet and all the Infinity Stones, The Mad Titan can easily erase Wade from existence, ending the fight in an instant.
Deadpool survived the Infinity War snap because he wasn't technically in the Marvel Cinematic Universe at the time. Marvel Studios boss Kevin Feige was asked about the Merc with a Mouth and jokingly gave the answer that certain hardcore McU fans have been wondering about since April of this year.
Able to regenerate from any and all injuries, including death, Craig Hollis is unable to die and therefore dubs himself Mister Immortal, vowing to fight crime. With the two-dimensional Flatman, they form the Great Lakes Avengers in the Wisconsin area, despite lacking official Avengers sanction.
His skin, like all his other internal organs, including his brain, constantly get cancer, which the healing factor fights off before they can become fatal.
One of the more surprising characters to lift Mjolnir was Deadpool. How was Deadpool ever worthy of Thor's hammer? That's because he wasn't. The hammer that Deadpool lifted was actually a fake one, forged by the trickster, Loki.
Because of Deadpool wearing the mutant-suppressing collar, he will lose his ability to heal from any injury. However when decapitates himself, his healing factor will regrow the rest of his body.