Semaglutide (Ozempic, Wegovy, Rybelsus) can cause side effects that some people are unable to tolerate. Following dosing guidelines can help manage these side effects. Nausea, vomiting, and diarrhea are the most common semaglutide side effects. But they usually subside after a few weeks of using the medication.
Nausea. Nausea was the most common side effect of Ozempic noted in clinical studies [4]. This is often described as an unsettled feeling in your stomach — or an upset stomach where you feel like you may need to vomit, but it may not always lead to vomiting.
Key Points. Your blood glucose (sugar) levels should start to fully decline within the first week after you start using Ozempic (semaglutide) at your regular maintenance dose. However, the full effect can take 8 weeks or longer, as this is a long-acting medication that is injected only once per week.
It's possible to feel fatigued when taking Ozempic. During clinical trials, a small number of participants—less than 0.4%—reported feeling tired while taking Ozempic. People might experience fatigue more often within the first few weeks of treatment.
It may last for a few weeks while your body gets used to the medication and while your dose is increasing. Fatigue may be caused by other factors, however, so how long it lasts can vary. Lower your sleep debt and get in sync with your circadian rhythm to boost your energy levels.
Stop using Ozempic® and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat.
You'll likely notice some changes in appetite and reductions in food cravings within the first week.
How can I maximise my body weight loss on Ozempic? You can assist Ozempic by lowering your overall calorie intake, moving your body where possible and limiting your alcohol consumption.
How much weight can you lose on Ozempic or Wegovy? In randomized clinical trials, patients receiving the 2.4 milligram dose of semaglutide lost a mean of 6% of their weight by week 12 and 12% of their weight by week 28, researchers reported.
Once you begin using Ozempic, some people can find it takes several weeks to see any weight loss, yet others may see some weight loss within a week or 2. While it can be difficult, try to remain patient — change looks different for everyone.
Nausea was the most common side effect reported by people taking the drug in clinical trials. For most people, the nausea was mild and temporary. You're more likely to have nausea when you first start Ozempic treatment or after your doctor increases your dose.
Semaglutide (Ozempic, Wegovy, Rybelsus) can cause side effects that some people are unable to tolerate. Following dosing guidelines can help manage these side effects. Nausea, vomiting, and diarrhea are the most common semaglutide side effects.
Common Side Effects of Ozempic
“The most common side effects are gastrointestinal in nature: nausea, vomiting, diarrhea and constipation.” While the majority of people who take Ozempic will most likely experience these symptoms at some point during their treatment, they should subside over time, continues Dr. McGowan.
So, on average, with the recommended starting Ozempic dose of 0.25 mg, a 500 to 1000 calorie reduced diet, and exercise 3 times a week, you can expect to lose 3-5 pounds in the first month of treatment, which works out to about 3% of body weight for most overweight or obese individuals.
“You have to eat what your body will accept.” Ozempic works, in part, by blocking the brain's hunger signals, suppressing appetite; it also causes the stomach to empty more slowly, leading people to feel full for longer.
Caffeine. Caffeine can also affect the action of Ozempic by causing low blood sugar levels or dehydration. Make sure you are consuming plenty of fluids throughout the day when taking this medication and limit caffeine consumption to no more than one cup of coffee per day.
Seeing results. Ozempic starts working within the first week of beginning your maintenance dose. Your blood sugar levels will start to decline during this time. Reaching the steady state can take about four to five weeks of once-a-week Ozempic doses.
If you don't have diabetes, taking Ozempic for weight loss is considered an off-label use. Wegovy, a higher-dose version of Ozempic, is approved to help people manage their weight. This includes adults and adolescents ages 12 and older who meet certain body mass index (BMI) criteria.
The starting Ozempic dosage is usually 0.25 mg once weekly. This dose isn't intended to have an effect on your blood glucose. Instead, it's meant to help your body start adjusting to digestion-related side effects.
8. Can Ozempic cause mood swings? In rare cases, the use of Ozempic may cause anxiety and mood swings, irritability, shakiness, and confusion. However, when you take other medications along with Ozempic, it may escalate anxiety or mood change.
“Ozempic face” is a term for common side effects of the type 2 diabetes medication semaglutide (Ozempic). It can cause sagging and aging of facial skin. A doctor may recommend lifestyle modifications or facial fillers to treat these effects.
Yes, Ozempic® can make you tired. Why the medication has this effect in some people is not fully understood. It could be because Ozempic decreases appetite which leads a person to eat less and therefore get less energy from food.