How long does it take for statins to get out of your system? It can take a few months for your cholesterol levels to return to what they were prior to the medication. Side effects will generally disappear a few weeks after your last dose.
About 5 to 10% of people who try statins are affected. It's more common in the elderly, in women and in those taking the more potent statins. Fortunately, these effects disappear within a month after stopping statin therapy.
You usually have to continue taking statins for life because if you stop taking them, your cholesterol will return to a high level.
Statins also increase the release of protective nitric oxide from the cells lining the inner walls of heart arteries. Animal research indicated that suddenly withdrawing statins causes a rebound phenomenon. Rather than simply returning to normal, the level of nitric oxide released by cells drops below normal.
It's important to know that stopping statins cold turkey, or even gradually, can cause serious health problems and you should talk to your doctor before doing so.
If you quit cold turkey, your body can go into shock. It is not recommended that you stop statins suddenly if you have a history of heart attack or stroke, as it can put you at a higher risk of recurrent heart attack. You should speak with your doctor before stopping the medicine under any circumstance.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
You will not get any withdrawal symptoms. However, stopping atorvastatin may cause your cholesterol to rise. This increases your risk of heart attacks and strokes. If you want to stop taking your medicine, it's important to find another way to lower your cholesterol.
Carimi says it's best to stick with the medication. He says the risk is too high, even if you're now living a better, healthier lifestyle. However, if you haven't had a stroke or heart attack and you are taking statins due to high cholesterol numbers, ending statin use might be an option.
Joseph A. Hill, M.D., Ph. D. The controversy in the United Kingdom started in 2013 when the British Medical Journal (BMJ) claimed statins were being overprescribed to people with low risk of heart disease, and that the drugs' side effects were worse than previously thought.
Anyone who wants to stop taking a statin should talk to a doctor. In some cases, coming off these drugs can be dangerous. The doctor may suggest reducing the dosage, combining the statin with another cholesterol lowering drug, or switching to another drug entirely.
Our analysis of current evidence suggests that intermittent statin administration is effective in lowering LDL levels in patients with dyslipidemia. All dosing regimens, including alternate days, 3 to 5 times a week, 2 to 3 times a week, and once a week, were shown to be effective.
Overall, statins are safe as a class of drugs. Serious adverse events are very rare. Among the individual medications, studies have shown that simvastatin (Zocor®) and pravastatin (Pravachol®) seem to be safer and better tolerated than the other statins.
Fortunately, severe liver injury is uncommon with statin use and is generally reversible without any intervention other than offending statin cessation.
Low-density lipoprotein (LDL) cholesterol.
If your risk is very low, you probably won't need a statin, unless your LDL is above 190 mg/dL (4.92 mmol/L). If your risk is very high — for example, you've had a heart attack in the past — a statin may be helpful even if you don't have high cholesterol.
The cholesterol-lowering action of alternate-day statins is as effective as daily dosing in many individuals. Alternate-day statin administration seems to decrease the incidence of its adverse effects, particularly myopathy.
If you forget to take your dose, take it as soon as you remember. If you do not remember until the next day, skip the missed dose and take the next one at the usual time. If you often forget doses, it may help to set an alarm to remind you.
So, why do people take statins at night? Many statins work more effectively when they are taken at night. This is because the enzyme which makes the cholesterol is more active at night. Also, the half-life, or the amount of time it takes for half the dose to leave your body, of some statins is short.
Background: Statins are generally well tolerated, but some patients discontinue therapy secondary to adverse effects. Dosing a statin (rosuvastatin) every other day (EOD) may provide significant lipoprotein changes while avoiding common adverse effects in this statin-intolerant population.
“Statins have a solid track record. In monitoring people taking statins for decades, we've found that they're safe and most people tolerate them well without any problems. But still, these misconceptions persist.”
Short-term statin exposure (< 2 years) was not associated with new onset type 2 diabetes in all statin subtypes, whereas long-term exposure (≥ 5 years) to statins was associated with a statistically significant increase in the risk of new onset type 2 diabetes in all statin subtypes.
Adults—5 to 40 milligrams (mg) once a day. Children 10 to 17 years of age—5 to 20 mg per day. Children 8 to 9 years of age—5 to 10 mg per day. Children younger than 8 years of age—Use and dose must be determined by your doctor.