1. How long does it take metformin to work? Metformin is a long-term medication. While not everyone with diabetes needs to take medication forever, many people will continue taking metformin for life.
It is recommended that metformin should be discontinued once eGFR falls below 30 ml/min/1.73 m2 and to decrease the metformin dose in mild to moderate renal impairment (eGFR 30–60 ml/min/1.73 m2).
Risks of stopping metformin
If left untreated, high blood glucose levels can lead to complications, such as: impaired vision, or diabetic retinopathy. kidney problems, or diabetic nephropathy. nerve damage, or diabetic neuropathy.
The American Diabetes Association (ADA) also recommends metformin for some people with prediabetes. Generally, if you're prescribed metformin, you'll be on it long term. That could be many decades, unless you experience complications or changes to your health that require you to stop taking it.
Summary. Metformin is a common drug for the treatment of diabetes. If you successfully manage your diabetes to remission, it's possible to stop taking metformin. Lifestyle and dietary changes can help you manage your blood sugar levels and possibly reach diabetes remission.
Metformin doesn't work for everyone. Precose, Januvia, Victoza, Glucotrol XL, and Actos are some metformin alternatives.
Recently, Samira et. reported no increase in the risk of acute kidney injury in patients receiving metformin compared to those without metformin treatment by baseline eGFR . However, in the present study, continuous metformin therapy was shown to worsen renal function in patients with DM and moderate CKD.
You'll have more energy as your body uses insulin more efficiently. Common diabetes-related symptoms, such as blurry vision, being thirsty all of the time, or having to pee a lot, improve or disappear.
Metformin lowers your blood sugar levels by improving the way your body handles insulin. It's usually prescribed for diabetes when diet and exercise alone have not been enough to control your blood sugar levels.
Long-term side effects
Taking metformin can cause vitamin B12 deficiency if you take it for a long time. This can make you feel very tired, breathless and faint, so your doctor may check the vitamin B12 level in your blood. If your vitamin B12 levels become too low, vitamin B12 supplements will help.
Official answer. Metformin (brand name: Glucophage) will be in your system for 96.8 hours which is approximately 4 days. Metformin has an elimination half-life of approximately 17.6 hours.
The administration of metformin, as glucophage retard, at bedtime instead of supper time may improve diabetes control by reducing morning hyperglycemia.
Conclusion: Metformin does not appear to cause or exacerbate liver injury and, indeed, is often beneficial in patients with nonalcoholic fatty liver disease. Nonalcoholic fatty liver frequently presents with transaminase elevations but should not be considered a contraindication to metformin use.
Diabetics should avoid fruits with a high GI or eat them in moderation so that their blood sugar levels do not spike abruptly. Pineapple, watermelon, mango, lychee, and banana have a high GI, so these are the worst fruits if you are diabetic.
More serious side effects are rare. They include severe allergic reactions and a condition called lactic acidosis, a buildup of lactic acid in the bloodstream. The risk for this is higher among people with significant kidney disease, so doctors tend to avoid prescribing metformin for them.
Learn about Berberine
A 2012 study published in European Journal of Endocrinology shows berberine has similar insulin normalizing benefits as Metformin for PCOS but without the side effects. Further, berberine was superior to Metformin in reducing other risk factors like waist circumference and waist-to-hip ratio.
Why Shouldn't You Stop Taking Metformin? Metformin works by decreasing the amount of sugar your liver releases into your blood, making your body more sensitive to insulin's effects. If you suddenly discontinue use, it can lead to dangerously high blood sugar levels.
Dosage and strength
The maximum daily dose is 2,000mg a day. This can be taken as four 500mg tablets a day. Liquid metformin should be taken in 5ml doses of 500mg, 850mg or 1,000mg.
Luckily, metformin may start to work within the first week of treatment. In one study of over 700 people, metformin ER lowered blood glucose within the first week of treatment. But it took about 2 months for it to have its full glucose-lowering effect.
Your doctor may increase your dose if needed until your blood sugar is controlled. Later, your doctor may want you to take 500 or 850 mg two to three times a day with meals. However, the dose is usually not more than 2550 mg per day.
The current drug labeling strongly recommends against metformin use in some patients whose kidneys do not work normally because use of metformin in these patients can increase the risk of developing a serious and potentially deadly condition called lactic acidosis, in which too much lactic acid builds up in the blood.