The ocular manifestations of cystic fibrosis (CF) typically present with ocular surface irritation or nyctalopia due to Vitamin A deficiency secondary to malabsorption; additionally decreased contrast sensitivity, oculosympathetic paresis, decreased lenticular transparency, and optic nerve dysfunction have been ...
Cystic fibrosis (CF) is a known risk factor of VAD because of liposoluble vitamin malabsorption due to pancreatic insufficiency. We describe a case of a 9-year-old girl who experienced recurrent episodes of nocturnal blindness due to profound VAD.
Patients with cystic fibrosis (CF) who have the CFTR loss of function mutation have an increased incidence of dry eye syndrome [12]. The most common mutation in CFTR in CF is ΔF508, accounting for approximately 70% of all mutations [15].
CF causes thick mucus that clogs certain organs such as the lungs, pancreas, and intestines. This may cause malnutrition, poor growth, frequent respiratory infections, breathing problems, and chronic lung disease.
Caring for anyone with a long-term disease — especially if that person is your child — is stressful. Parents of children with cystic fibrosis are more likely to experience anxiety, depression, or both compared to parents in general.
People with chronic diseases, such as cystic fibrosis, are at greater risk for developing clinical depression. When left untreated, depression can interfere with your ability to manage your CF effectively and experience a better quality of life.
Important areas to assess in youth with CF include psychological factors such as symptoms of depression, anxiety, and stress. CF Foundation guidelines recommend that patients with CF complete a screener for depression and anxiety as a routine component of clinic visits.
Eating disorders and disturbed body image have been reported in individuals with cystic fibrosis (CF) and may contribute to poor weight gain, reduced lung function and increased mortality.
The CFTR gene mutation can cause the CFTR protein to malfunction and affect multiple organs and systems, including lungs, upper respiratory tract, gastrointestinal tract, pancreas, liver, sweat glands, and genitourinary tract [5], and may also affect brain.
Cystic fibrosis affects various organ systems in children and young adults, including the respiratory system, digestive system and reproductive system.
Congenital fibrosis of the extraocular muscles (CFEOM) is a disorder of the nervous system that affects use of the muscles that surround the eyes (extraocular muscles). These muscles control eye movement and the direction of the eyes (for example, looking straight ahead). CFEOM impairs control of these muscles.
Ocular fibrosis is a complex biological process responsible for the pathogenesis or treatment failure of many blinding eye diseases, including corneal and conjunctival scarring, open-angle glaucoma and failure of glaucoma filtration surgery (GFS), fibrosis in the lens capsule post-cataract surgery, scarring in the ...
Cystic fibrosis tends to get worse over time and can be fatal if it leads to a serious infection or the lungs stop working properly. But people with cystic fibrosis are now living for longer because of advancements in treatment. Currently, about half of people with cystic fibrosis will live past the age of 40.
People with CF who have had a lung or any solid-organ transplant may be particularly vulnerable to serious illness from COVID-19 due to medications that suppress their immune systems to prevent organ rejection.
Literature suggests that CF may be associated with developing cataracts; however, the true prevalence of cataracts in CF patients is unknown since a cataract may remain undetected until vision is impaired. This analysis characterizes cataract frequency in patients homozygous for the F508del-CFTR mutation.
Symptoms of cystic fibrosis depend on which organs are affected and the severity of the condition. The most serious and common complications of cystic fibrosis are problems with the lungs, also known as pulmonary or respiratory problems, which may include serious lung infections.
These thick secretions also obstruct the pancreas, preventing digestive enzymes from reaching the intestines to help break down and absorb food. Cystic fibrosis does not affect intelligence.
Possible Complications of Living with Cystic Fibrosis
Respiratory diseases are the most common and include damaged airways (bronchiectasis), chronic infections, growths in the nose (nasal polyps), coughing up blood (hemoptysis), pneumothorax, and respiratory failure.
It is caused by a defective gene that makes the body produce abnormally thick and sticky fluid, called mucus. This mucus builds up in the breathing passages of the lungs and in the pancreas. The buildup of mucus results in life-threatening lung infections and serious digestion problems.
The sticky mucus from cystic fibrosis can block normal absorption of key nutrients and fat in the intestines, causing: poor digestion. slow growth. trouble gaining weight.
Skeletal muscle weakness and exercise intolerance are prevalent in cystic fibrosis.
CF affects many different organs in the body, making people with the disease more likely to develop other health conditions including diabetes, cirrhosis (liver disease), arthritis, reflux, hypersplenism (overactive spleen), and osteoporosis.
Cystic fibrosis (CF) is a chronic, progressive, and frequently fatal genetic (inherited) dis ease of the body's mucus glands. CF pri marily affects the respiratory and digestive systems in children and young adults. The sweat glands and the reproductive system are also usually involved.
Neurological problems that do occur are more likely secondary to other sequelae of cystic fibrosis, such as: Headache (common) - possibly a reflection of sleep disordered breathing, or chronic hypoxia/hypercarbia.