Dendrites are cellular extensions found in the neurons, or nerve cells. This suggests that depression is not an irreversible neurodegenerative disorder. Instead, its impact on the brain may be reversible, and the brain can heal.
A depression not only makes a person feel sad and dejected – it can also damage the brain permanently, so the person has difficulties remembering and concentrating once the disease is over. Up to 20 percent of depression patients never make a full recovery.
And, since depression is often a long-term disease, people needs long-term treatments for it. “There are clear differences between a healthy brain and a depressed brain,” Dr. Katz says. “And the exciting thing is, when you treat that depression effectively, the brain goes back to looking like a healthy brain.”
To further enhance your brain function as you recover from depression, it is vital to get at least 7 hours of sleep each night, increase your social connectedness, and avoid alcohol and recreational drugs like marijuana because they adversely affect cognition and mood.
Depression causes the hippocampus to raise its cortisol levels, impeding the development of neurons in your brain. The shrinkage of brain circuits is closely connected to the reduction of the affected part's function. While other cerebral areas shrink due to high levels of cortisol, the amygdala enlarges.
The main subcortical limbic brain regions implicated in depression are the amygdala, hippocampus, and the dorsomedial thalamus. Both structural and functional abnormalities in these areas have been found in depression. Decreased hippocampal volumes (10, 25) have been noted in subjects with depression.
Research suggests that depression doesn't spring from simply having too much or too little of certain brain chemicals. Rather, there are many possible causes of depression, including faulty mood regulation by the brain, genetic vulnerability, and stressful life events.
There's no cure for depression, but you still have plenty of options for treatment, all of which can improve your symptoms and minimize their impact on your daily life.
The sooner you start managing your stress effectively, the easier it will be to keep unexpected stress from causing damage in the future. Luckily, the plasticity of the brain allows it to mold, change, and rebuild damaged areas as you practice new behaviors.
As discussed, depression is believed to affect short-term memory loss. When the underlying symptoms are treated, memory issues typically subside. A recent 2019 study found a potential way to reverse the memory loss linked to both depression and aging.
For people with chronic or severe depression, medication may be needed on a long-term basis. In these cases, antidepressants are often taken indefinitely. That is, in part, because depression is not an illness that can be cured.
Untreated clinical depression is a serious problem. Untreated depression increases the chance of risky behaviors such as drug or alcohol addiction. It also can ruin relationships, cause problems at work, and make it difficult to overcome serious illnesses.
If you or someone you love is struggling with addiction, know this – the brain can heal from the aftermath of chemical dependency. Experts suggest 90 days as a general estimate for rewiring the brain, but everyone is different.
Luckily, the plasticity of the brain allows it to mold, change, and rebuild damaged areas as you practice new behaviors. So implementing healthy stress-relieving techniques can train your brain to handle stress more effectively and decrease the likelihood of ill effects from stress in the future.
There's no cure for mental illness, but there are lots of effective treatments. People with mental illnesses can recover and live long and healthy lives.
A PET scan can compare brain activity during periods of depression (left) with normal brain activity (right). An increase of blue and green colors, along with decreased white and yellow areas, shows decreased brain activity due to depression.
Studies have demonstrated the reverse neuroplasticity effects of antidepressant therapies. Antidepressants were observed to promote neurogenesis in the hippocampus and to strengthen functional connectivity (72,73).
People with clinical depression often have increased levels of monoamine oxidase A (MAO-A), an enzyme that breaks down key neurotransmitters, resulting in very low levels of serotonin, dopamine and norepinephrine.
There's no single cause of depression. It can occur for a variety of reasons and it has many different triggers. For some people, an upsetting or stressful life event, such as bereavement, divorce, illness, redundancy and job or money worries, can be the cause. Different causes can often combine to trigger depression.
Clinicians generally recommend staying on the medication for six to nine months before considering going off antidepressants. If you've had three or more recurrences of depression, make that at least two years.