Ozempic (Semaglutide) will take 5 weeks to get going and get into your system. It won't reach, what we call steady state, until that time.
You'll likely notice some changes in appetite and reductions in food cravings within the first week.
Nausea was the most common side effect reported by people taking the drug in clinical trials. For most people, the nausea was mild and temporary. You're more likely to have nausea when you first start Ozempic treatment or after your doctor increases your dose.
How can I maximise my body weight loss on Ozempic? You can assist Ozempic by lowering your overall calorie intake, moving your body where possible and limiting your alcohol consumption.
Although steady state levels are reached in 4 to 5 weeks, clinical effectiveness with Ozempic will vary from person to person and may take longer due to unique factors such as age, weight, amount of body fluid, additional medications you take, kidney or liver function, or your other medical conditions.
Ozempic is a long-acting medication, and it may take up to eight weeks for you to fully feel its effects. Health providers prescribe Ozempic at a lower starting dose, such as 0.25 mg. The lower starting dose may make it easier for your body to adjust to using Ozempic, which can help reduce side effects.
Seeing results. Ozempic starts working within the first week of beginning your maintenance dose. Your blood sugar levels will start to decline during this time. Reaching the steady state can take about four to five weeks of once-a-week Ozempic doses.
Once you begin using Ozempic, some people can find it takes several weeks to see any weight loss, yet others may see some weight loss within a week or 2. While it can be difficult, try to remain patient — change looks different for everyone.
The active ingredient in Ozempic is semaglutide, which works by inducing satiety. This feeling of being satisfied or “full”, suppresses appetite. This is why it works for weight loss.
How much weight can you lose on Ozempic or Wegovy? In randomized clinical trials, patients receiving the 2.4 milligram dose of semaglutide lost a mean of 6% of their weight by week 12 and 12% of their weight by week 28, researchers reported.
Ozempic works, in part, by blocking the brain's hunger signals, suppressing appetite; it also causes the stomach to empty more slowly, leading people to feel full for longer. When people are on a drug like Ozempic, doctors need to monitor them closely with regular check-ins, Dr. Kraftson said.
Refined carbohydrates
This can make it harder to manage blood sugar levels in people both with and without diabetes. These types of foods are typically lacking fiber, which can send blood sugar levels soaring. It is best to avoid refined carbohydrates if you're taking Ozempic.
High fat foods or sugary foods
Ozempic can cause nausea and vomiting if taken after eating foods high in fat or sugar. It is recommended that you take Ozempic before meals, rather than after, to minimise any potential side effects from eating high-fat or high-sugar foods.
Semaglutide (Ozempic, Wegovy, Rybelsus) can cause side effects that some people are unable to tolerate. Following dosing guidelines can help manage these side effects. Nausea, vomiting, and diarrhea are the most common semaglutide side effects.
So, on average, with the recommended starting Ozempic dose of 0.25 mg, a 500 to 1000 calorie reduced diet, and exercise 3 times a week, you can expect to lose 3-5 pounds in the first month of treatment, which works out to about 3% of body weight for most overweight or obese individuals.
If you don't have diabetes, taking Ozempic for weight loss is considered an off-label use. Wegovy, a higher-dose version of Ozempic, is approved to help people manage their weight. This includes adults and adolescents ages 12 and older who meet certain body mass index (BMI) criteria.
Teresa Shepherd said she lost 90 pounds while taking an off-brand version of the drug Ozempic for around eight months. Shepherd, who lives in Florida, told "Good Morning America" she has been able to maintain her weight loss two months after stopping the medication.
Common Side Effects of Ozempic
“The most common side effects are gastrointestinal in nature: nausea, vomiting, diarrhea and constipation.” While the majority of people who take Ozempic will most likely experience these symptoms at some point during their treatment, they should subside over time, continues Dr. McGowan.
“Ozempic face” is a term for common side effects of the type 2 diabetes medication semaglutide (Ozempic). It can cause sagging and aging of facial skin. A doctor may recommend lifestyle modifications or facial fillers to treat these effects.
Stop using Ozempic® and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat.
It may last for a few weeks while your body gets used to the medication and while your dose is increasing. Fatigue may be caused by other factors, however, so how long it lasts can vary. Lower your sleep debt and get in sync with your circadian rhythm to boost your energy levels.
Ozempic is a long-acting medication that can cause severe hypoglycemia (low blood sugar) if not taken exactly as prescribed. If you do take more than your prescribed dose, call your provider immediately and monitor for signs and symptoms of low blood sugar, which include (ADA, n.d.): Headache. Dizziness.
Avoiding alcohol and caffeine with Ozempic®
Caffeine may also cause your blood sugar levels to fluctuate, possibly increasing the risk for hypoglycemia when taking Ozempic® at the same time.