Metformin does not instantly reduce blood sugar levels. The effects are usually noticeable within 48 hours of taking the medication, and the most significant effects take 4–5 days to occur. However, the timing depends on the person's dosage.
Luckily, metformin may start to work within the first week of treatment. In one study of over 700 people, metformin ER lowered blood glucose within the first week of treatment. But it took about 2 months for it to have its full glucose-lowering effect.
If your blood sugar is high despite medication, it could mean a few things: Your dosage is not high enough, you are not responding to the medication as expected, or your diet, exercise, and lifestyle are not helping enough to control your blood sugar.
You'll have more energy as your body uses insulin more efficiently. Common diabetes-related symptoms, such as blurry vision, being thirsty all of the time, or having to pee a lot, improve or disappear.
Using metformin alone, with a type of oral antidiabetic medicine called a sulfonylurea, or with insulin, will help to lower blood sugar when it is too high and help restore the way you use food to make energy. Many people can control type 2 diabetes with diet and exercise.
The administration of metformin, as glucophage retard, at bedtime instead of supper time may improve diabetes control by reducing morning hyperglycemia.
As much as possible, avoid white bread, white rice, white pasta, candy, soda, desserts, and snacks like chips or crackers. Eating foods that can spike your blood sugar will not necessarily make the metformin not work, however, it will increase the burden it has to work against.
Metformin does cause side effects in some people, but many of these are mild, and are associated with taking the medicine for the first time. Nausea and gastric distress such as stomach pain, gas, bloating, and diarrhea are somewhat common among people starting up on metformin.
You may notice improvement in your blood glucose control in 1 to 2 weeks, but the full effect of blood glucose control may take up to 2 to 3 months. Ask your doctor if you have any questions about this.
Official answer. Metformin (brand name: Glucophage) will be in your system for 96.8 hours which is approximately 4 days. Metformin has an elimination half-life of approximately 17.6 hours.
If metformin no longer works for you, your doctor may add another drug to your treatment plan. “But there's no magical second drug; the secondary options will depend on the individual,” she says. Your doctor may prescribe other oral medications or noninsulin injectables.
Your blood sugar may fall too low if you take metformin while fasting or doing very heavy physical activity. If you're taking a combination pill, or metformin with other diabetes medications or insulin, check with your doctor about how likely you are to have low blood sugars.
Agents to be considered after metformin should be DPP-4 inhibitors or GLP-1 agonists if hypoglycemia and weight gain are a concern, or alternatively, sulfonylureas if fasting and postprandial glucose levels are elevated and a greater degree of A1C lowering is needed.
Metformin is very effective at controlling blood glucose and lowers A1c levels by as much as 1.5% at maximum doses.
Some serious side effects caused by metformin are dangerous and require immediate medical attention. If you experience any of the following, consult with a healthcare professional right away: Tiredness. Unusual sleepiness.
It's best to take metformin tablets with, or just after, your evening meal to reduce the chance of getting side effects. Swallow your metformin tablets whole with a drink of water.
Metformin and weight loss
In a much larger trial in over 4,000 people with type 2 diabetes, it was found metformin use was associated with a 2.4 kg (roughly 5.3 lbs) weight loss over a four-year period. There are a few ways that metformin might impact weight. One is that the medication can reduce your appetite.
DO NOT take 2 doses at the same time. Common Side Effects: Loose stools/diarrhea, upset stomach, and gas. These USUALLY GET BETTER if you keep taking your metformin. Try taking it with food.
Periodontal Disease and Diabetes
Medications used by people with diabetes such as Glipizide and Metformin may cause changes to the oral cavity, such as candidiasis, burning mouth, xerostomia, and the chance of getting periodontal disease and caries.
Severe Side Effects of Metformin
Anemia: Metformin can interfere with the body's ability to absorb vitamin B12, which plays an important role in healthy red blood cells. If this happens, it can lead to anemia, which may cause symptoms like extreme tiredness, feeling cold all the time, and dizziness.
Taking metformin with a meal has been shown to decrease bioavailability of metformin. We hypothesized that taking metformin 30 min before a meal improves glucose metabolism.
Metformin side effects can include diarrhea, nausea and vomiting, and gas. Taking metformin on a schedule can help reduce side effects. Most metformin side effects are short-term, which is 2 weeks or less. See a healthcare provider if you're experiencing long-term metformin side effects.
Barley or jau water is high in insoluble fibre, which makes it good for diabetics. It is recommended for diabetics as it helps stabilise blood glucose levels. Make sure you drink unsweetened barley water to get effective results. The antioxidant properties of barley water also helps keep many diseases at bay.
Should you drink a lot of water when consuming this medicine? Metformin must be consumed with meals to assist lower stomach or bowel side effects that might happen during the initial few weeks of treatment. The tablet or extended-release tablet must be taken whole with a full glass of water.