A significant increase in eGFR was seen in a small population of patients with CKD practicing intermittent fasting for four months or more. Previous studies report an average annual decline in GFR of 1.5-2 ml/min/1.73 m2 in the general CKD population, with a more rapid decline in certain subsets.
Of these 74 has a post-fasting kidney test. Of the patients, 68.1% had stage 3A CKD, 21.7% had stage 3B, 7.9% stage 4, and only 2% stage 5. Of those who fasted, 11.1% had a drop in Glomerular Filtration Rate (eGFR) of 20% or more.
Healthcare providers may tell you not to eat or drink anything, except water, after midnight. You may also be asked not to eat any cooked meat the night before the test. It can increase the level of creatinine in your blood and affect your GFR results.
Good preparation and planning can avoid problems during fasting. Dehydration can have a negative impact on the kidneys, building up a waste and acids in the body, and potentially leading to kidney stones, urinary tract, kidney damage and disease if left untreated.
A decrease or decline in the GFR implies progression of underlying kidney disease or the occurrence of a superimposed insult to the kidneys. This is most commonly due to problems such as dehydration and volume loss.
Glomerular filtration rate is a measure of functional renal mass. Reductions in GFR can occur with primary renal disease, decreased renal perfusion, or obstructive renal disease.
What are the main causes of a low EGFR? If one's low EGFR is kidney-related, the most common causes for this typically include hypertension, diabetes, and other conditions that can cause vascular disease.
The estimated glomerular filtration rate (eGFR) is variable and it relies on a blood test, which may have day to day variations and it is an "estimation". Hence, the more times you do the test, the more accurate will be the estimate.
Water ingestion can acutely affect GFR, although not necessarily in the direction one might expect. Using 12 young, healthy individuals as their own controls, Anastasio et al. found increased water intake actually decreases GFR.
Fasting effects various body systems, apart from the renal system. Fasting can also increase serum creatinine levels because of dehydration.
In this population-based study, we examined factors associated with glomerular filtration rates (GFR) in both genders. The findings of our study showed that obesity, diabetes, blood urea nitrogen, atherogenic factor, hypertension, meat consumption, and smoking were associated with lower GFR.
Avoid processed foods and choose fresh fruits and vegetables instead. Follow a low-salt diet. Salt should be limited especially if you have high blood pressure, protein in your urine, or swelling, or difficulty breathing. Eating less than 2000 mg a day of sodium is recommended.
Do I need to do anything to prepare for my eGFR test? Your doctor may have you fast (not eat or drink) or avoid certain foods for several hours before the test. They will let you know how to prepare.
Dehydration does cause the serum creatinine to rise and the estimated glomerular filtration rate (eGFR) will, accordingly, fall.
After the meal, there were significant increases in urinary excretion of Na (in the low hydration regimen) and urea (90 to 180 min after the meal). Conclusions: In fasting adults, high hydration lowered GFR and increased natriuresis.
People with mildly low gFR (between 60 and 89) may not have kidney disease if there is no sign of kidney damage, such as protein in their urine. these people should have their gFR checked more often.
Classically dehydration results in a 'pre-renal state' associated with intrarenal vasoconstriction but with relative maintenance of glomerular filtration rate (GFR).
Furthermore, eGFR fluctuates; for example, in a 60-year-old man with a serum creatinine of 0.7 mg/dL, a 0.1 mg/dL change in serum creatinine would result in a 13.6% change in eGFR (from 88.5 mL/min/1.73 m2 to 76.5 mL/min/1.73 m2).
Following the classical way, we can assert that normal GFR values are largely over 60 mL/min/1.73 m2 in healthy subjects, at least before the age of 70 years. However, we know that GFR physiologically decreases with age, and in adults older than 70 years, values below 60 mL/min/1.73 m2 could be considered normal.
In normal individuals, glomerular filtration rate (GFR) measured by inulin and creatinine clearance reaches a maximum during the day, peaking around 2–3 p.m., and a minimum in the middle of the night [11–13].
Normal Results
Older people will have lower than normal GFR levels, because GFR decreases with age. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.
Psychosocial stress was not directly associated with any of the four measures of the eGFR.
It is only an estimate of kidney function and a significant error is possible. The eGFR is most likely to be inaccurate in people at extremes of body type e.g. patients with limb amputations, severely malnourished and morbidly obese individuals.
A low eGFR in an older person does not always mean CKD, even if the eGFR is less than 60. When you get an eGFR test, a simple urine test called the uACR will also be done to check for blood or albumin (a type of protein) in the urine.