Few studies had compared the effect of betahistine and metformin before. According to our study, although betahistine group failed to decrease the body weight significantly, it prevented further weight gain with a decreasing tendency.
It was taken off the market in the United States in 1970 because it was thought to be ineffective for vertigo, but is still used for this purpose in many other countries. Some research suggests that betahistine may reduce appetite and food intake.
Your doctor may advise you to try betahistine for 6 to 12 months to see if it helps to reduce your symptoms. If it does, it can then be continued.
Taking too much betahistine can make you feel sick or sleepy, or give you stomach ache.
Antihistamines, e.g. betahistine and cinnarizine. These are sedative, and patients should not operate machinery or drink alcohol.
It has been found to improve vestibular compensation in animal models of unilateral vestibular dysfunction, by increasing vestibulocochlear blood flow and reducing the histamine-induced excitatory response in vestibular cells by blocking local H(3) autoreceptors [8].
Do not stop taking this medicine suddenly, or change the dosage, without checking with your doctor. Do not use this medicine to treat any other complaints unless your doctor or pharmacist tells you to. Do not give this medicine to anyone else, even if they have the same condition as you.
If you stop taking Betahistine
Keep taking your tablets until your doctor tells you to stop. Even when you start feeling better, your doctor may want you to carry on taking the tablets for some time to make sure that the medicine has worked completely.
Some medicines and betahistine affect each other and can increase your chance of side effects. Tell your pharmacist or doctor if you're taking: medicines called MAO inhibitors, used to treat depression or Parkinson's disease. antihistamines for allergies such as hay fever.
Anxiety symptoms
The repeated-measures ANOVA showed a significant effect of time (P<0.00001), indicating that both high-dose and low-dose betahistine could significantly reduce the HARS score.
Increases in vestibular blood flow and decreases in blood pressure were observed in response to betahistine infusions.
Conclusion: Betahistine prevented PTZ-induced memory loss; an effect could be in part attributed to the enhanced cholinergic activity and GSK3-β inhibition.
Betahistine is not approved in the United States. Interestingly, it was approved in the U.S. in the 1960s but after 5 years the approval was withdrawn due to a lack of evidence for its efficacy.
Ginkgo biloba
It works by managing blood flow to the brain to relieve dizziness and balance issues. A study reported in the International Journal of Otolaryngology finds Ginkgo biloba is just as effective as the medication betahistine in managing vertigo.
Duration of Therapy
If betahistine is used as a vestibular suppressant and only for symptomatic relief of vertigo, the duration should be limited to a maximum of 3 to 5 days and not more than that just like any other vestibular sedative.
This medication may irritate the stomach, and should be taken with food. It is best to avoid coffee, spicy food or alcohol.
Betahistine is the analogue of histamine with weaker agonistic effect on histamine H1 receptors and stronger effect on histamine H3 receptors, while Cinnarizine has more effective effect on H1 receptors.
Betahistine Brand name: Serc.
What does the research say? Studies did not show differences in tinnitus loudness, severity of tinnitus symptoms or side effects between participants receiving betahistine and participants receiving a placebo[1].
Taking it at the same time each day will have the best effect. It will also help you remember when to take it. Take BETAHISTINE VIATRIS during or immediately after a meal. If you take BETAHISTINE VIATRIS on an empty stomach, it may cause stomach upsets.
Vitamin D and Calcium Prevent Recurrent Vertigo.
It has been suggested that betahistine hydrochloride reduces the frequency and severity of vertiginous episodes and tinnitus and arrests the progression of hearing loss in patients with Ménière's syndrome (Solvay 1998).
Betahistine Hydrochloride is the hydrochloride salt form of betahistine, a histamine analog with weak histamine H1 agonistic and more potent histamine H3 antagonistic properties.