Although April wanted to fight for their relationship, the couple couldn't work through their differences, leading to them officially divorcing in season 12, episode 11, "Unbreak My Heart". Given their extensive history, this felt like an end of an era as no one thought they would ever break up.
Jackson Avery and Dr. April Kepner — and to fans' delight, "Japril" finally got back together! Sarah Drew, who played April on the Shondaland hit from 2009 to 2018, told PEOPLE returning to set and to her character "felt like coming home."
In season 12, April and Jackson go through divorce proceedings started by Jackson. The morning before they sign the divorce papers, April discovers that she is expecting a second baby.
They lost their first child — a son named Samuel Norbert Avery — to osteogenesis imperfecta on Grey's Anatomy Season 11 Episode 11, “All I Could Do Was Cry.” Sadly, they never learned how to be there for each other while grieving him, and his loss is essentially the catalyst for their divorce.
The character ultimately married paramedic Matthew Taylor (Justin Bruening), the former fiancé she'd left at the altar to run away with Jesse Williams' Jackson Avery. Throughout the series, Jackson and April's relationship was affectionately dubbed "Japril," and many fans lamented that they didn't end up together.
He married Kepner and had two children: a son, Samuel, who died of osteogenesis imperfecta type II, and a daughter named Harriet.
A series of surgeries follows, including the delivery of her premature baby, along with emotional breakdowns of both Sloan and Robbins. Upon the awakening of Torres, she accepts her marriage proposal, and the two are married by Miranda Bailey (Chandra Wilson).
Thursday's episode featured the former couple in a bitter custody battle for their daughter Sofia that ended with Arizona gaining full custody.
He is pronounced brain dead and, wanting something good to come from it, Jo decided to donate his organs for transplant. Jo and Alex have their wedding in "All of Me".
Callie and Arizona have a five-year relationship, ultimately marrying in season 7 and divorcing in season 11. Callie starts a new relationship with Penny Blake and leaves to go to New York with her in the season 12 finale.
Jackson professed his love for April as she stood at the altar with Matthew. So, April and Jackson ran off together and eloped. April and Jackson get pregnant unexpectedly. While they are initially overjoyed, their joy is short-lived when they learn their baby has Osteogenesis Imperfecta type 2.
Back in season 12, Jo learns about Alex and Izzy's frozen embryos from when the latter had cancer, and they briefly talk about their future together. Alex was down to have a baby with Jo, but they both decided that it wasn't time for them yet.
Later, she marries Owen but expresses doubt and second thoughts before the wedding in the season 12 finale. The thirteenth season sees Amelia and Owen's marriage face problems when the idea of pregnancy brings repressed memories of the death of her firstborn son, Christopher.
Season 11, episode 11: Their baby got a fatal diagnosis
April's labor was induced so she could give birth and they could meet their son and say goodbye. Their son, Samuel Norbert Avery, died soon after. Viewers later saw a scene of the two grieving in the flashbacks during their dedicated episode, "Unbreak My Heart."
Sarah Drew will not be reprising her role of Jackson's fellow doctor and on-again/off-again/back-on-again love interest, April Kepner.
She meets an ex's colleague, Dr. Nathan Riggs, but she eventually decides to stay single; she has also been linked to Dr. Cormac Hayes, her colleague and friend, but it remains platonic. Ultimately, Meredith remains single after Derek's death, and continues to dedicate herself to her career and children.
Luna Wilson is the daughter of Jo Wilson, who was born to her late patient Val Ashton.
Grey's Anatomy season 19, episodes 14 and 15 were released on Thursday, April 13, 2023, and it saw Maggie Pierce and Winston break up. The two broke up after Maggie quit her job in Seattle to move to Chicago to explore more opportunities.
Wilson-Karev was conceived during a rape. Jo informs her mom she was in an abusive marriage, which viewers are already painfully aware of. Then, Jo drops what may be the final major secret of her past: She had an abortion.
Arizona sends Penny to take more tests and when April still feels uncomfortable Arizona decides to put her and the baby under anesthesia so they can do a MRI to make sure the baby is okay. After putting us all through a very stressful episode the MRI confirms that April and Jackson's baby is indeed okay.
The reason Arizona won that custody battle is because she was the better person to raise Sofia. Callie decided to run off to New York with her girlfriend of a few months and thought it would be fine to drag her child across the country, away from all her friends, away from her school, and away from her other mom.
Alex Karev's fate was finally revealed during Thursday's episode of Grey's Anatomy. After Alex (Justin Chambers) planned to take a plea deal that would see him go to jail for two years, Meredith (Ellen Pompeo) finally located him—but Alex wasn't in jail!
After Arizona won custody of Sofia, Callie and Penny broke up and she was last seen departing for New York in the penultimate season 12 episode “At Last.” However, in the season finale, Arizona let Callie take Sofia to New York where she and Penny were reunited off-screen.
After 10 years at Grey Sloan, Callie unceremoniously left the hospital when her girlfriend Penny (Samantha Sloyan) scored a grant that took her to the East Coast. Ramirez's swan song was initially unclear as the cast was going through contract negotiations, so many fans didn't get closure when she exited.
Ben is able to save both April and her daughter's lives, while Arizona makes amends with Callie and allows her to move with Penny and share custody of Sofia.