Yet, another study found that both low and high magnesium concentration levels were associated with a greater risk of all-cause dementia [172].
Early signs of excessive magnesium intake can include low blood pressure, facial flushing, depression, urine retention, and fatigue. Eventually, if untreated, these symptoms can worsen and include muscle weakness, difficulty breathing, irregular heartbeat, and even, in very rare cases, cardiac arrest.
Acute or chronic Mg deficiency may affect the nervous system. Acute Mg deficiency leads to metabolic encephalopathy and alteration of neuromuscular excitability, such as deprementia and nervousness. By contrast, chronic Mg deficiency is characterized by spasm.
However, yet another study suggested that both too high and too low an intake of magnesium could raise the risk of dementia. Further research on the link between magnesium and cognitive status could inform preventative strategies for dementia.
High doses of magnesium from supplements or medications can cause nausea, abdominal cramping and diarrhea. In addition, the magnesium in supplements can interact with some types of antibiotics and other medicines.
Severe hypermagnesemia (levels greater than 12 mg/dL) can lead to cardiovascular complications (hypotension, and arrhythmias) and neurological disorder (confusion and lethargy). Higher values of serum magnesium (exceeding 15 mg/dL) can induce cardiorespiratory arrest and coma.
Magnesium can also reduce physiological symptoms like headaches, muscle pain, back pain, and stomach pain. In addition, magnesium benefits mental health by acting as a mood booster, muscle relaxer, stress reducer, and sleep aid.
Cognitive delays
Commonly referred to as brain fog, slow cognition or difficulty with concentration and memory can all indicate magnesium deficiency. Magnesium is an essential nutrient for the brain, so without it the brain cannot perform as well.
Magnesium also modulates activity of the hypothalamic pituitary adrenal axis (HPAA) which is a central substrate of the stress response system. Activation of the HPAA instigates adaptive autonomic, neuroendocrine, and behavioral responses to cope with the demands of the stressor; including increasing anxiety.
Magnesium deficiency can cause a wide variety of features including hypocalcaemia, hypokalaemia and cardiac and neurological manifestations. Chronic low magnesium state has been associated with a number of chronic diseases including diabetes, hypertension, coronary heart disease, and osteoporosis.
Symptoms of magnesium toxicity, which usually develop after serum concentrations exceed 1.74–2.61 mmol/L, can include hypotension, nausea, vomiting, facial flushing, retention of urine, ileus, depression, and lethargy before progressing to muscle weakness, difficulty breathing, extreme hypotension, irregular heartbeat, ...
The benefits of magnesium supplementation in healthy individuals aren't clear, but Dr. Nassar says that taking a magnesium supplement every day likely isn't unsafe for most people. Just be sure you're not taking too much magnesium. The maximum dietary allowance for most adults is around 400 mg or less.
“Most magnesium will stay in the body for anywhere from 12 to 24 hours. So it's not something you can just take once, see results, and then never take again,” explains registered dietitian Amanda Li, R.D.
Antibiotics: Taking magnesium supplements may reduce the absorption of quinolone antibiotics, tetracycline antibiotics, and nitrofurantoin (Macrodandin). Magnesium should be taken 1 hour before or 2 hours after taking these medications. Quinolone and tetracycline antibiotics include: Ciprofloxacin (Cipro)
Antibiotics -- The absorption of quinolone antibiotics, such as ciprofloxacin (Cipro) and moxifloxacin (Avelox), tetracycline antibiotics, including tetracycline (Sumycin), doxycycline (Vibramycin), and minocycline (Minocin), and nitrofurantoin (Macrodandin), may be diminished when taking magnesium supplements.
Intravenous calcium, diuretics, or water pills may also be used to help the body get rid of excess magnesium. People with renal dysfunction or those who have had a severe magnesium overdose may require dialysis if they are experiencing kidney failure, or if magnesium levels are still rising after treatment.
Side effects from too much magnesium are unusual, because the body clears excess magnesium naturally. In rare cases, magnesium toxicity can cause dizziness or fainting, flushing, or muscle paralysis. An overdose is extremely unlikely, but can happen in people with kidney disease.
What is brain fog syndrome? Brain fog is characterized by confusion, forgetfulness, and a lack of focus and mental clarity. This can be caused by overworking, lack of sleep, stress, and spending too much time on the computer.
Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor's recommendation. Severe interactions with magnesium supplement include: baloxavir marboxil.
Magnesium inhibits calcium-dependent brain dopamine release [7]. By decreasing glutamate action on NMDA receptors in the brain. By stimulation of NMDA receptors, glutamate increases synaptic dopamine release.
Side effects of magnesium
Taking magnesium supplements can bring a range of side effects, such as drowsiness or fatigue during the day, muscle weakness, nausea, vomiting, skin flushing or diarrhea, Gurubhagavatula said. Some risks are even more serious.