The DNA of monozygotic twins tends not to be 100% identical, and epigenetic and environmental differences further widen the gap between twin pairs. It's not nature or nurture; it's a complex interaction between our genes, our environment, and our epigenetic markers that shape who we are and what illnesses befall us.
The study of 381 pairs of identical twins and two sets of identical triplets found that only 38 were genetically identical, Tina Hesman Saey reports for Science News. Most had just a few points of genetic mismatch, but 39 had more than 100 differences in their DNA.
It is true that identical twins share their DNA code with each other. This is because identical twins were formed from the exact same sperm and egg from their father and mother. (In contrast, fraternal twins are formed from two different sperm and two different eggs.)
Identical Twins
Identical twins share the same genomes and are always of the same sex. In contrast, fraternal (dizygotic) twins result from the fertilization of two separate eggs with two different sperm during the same pregnancy. They share half of their genomes, just like any other siblings.
Identical (i.e., monozygotic, or MZ) twins share 100 percent of their genes, whereas fraternal (i.e., dizygotic, or DZ) twins generally share only 50 percent of their genes.
The bottom line
Identical twins share a lot of similarities in both their genetic makeup and their physical appearances. But, like those who aren't twins, identical twins all have unique fingerprints.
Like for their twin parents, there are many fascinating family relationships for the children of twins–when identical twins have children, their children are cousins but genetically as similar as half-siblings.
Identical twins will always have the same blood type because they were created from the same fertilized egg (fraternal twins can have different blood types — again, providing the parents do — because they are created by two fertilized eggs).
The gene versions that increase the chance of hyperovulation can be passed down from parent to child. This is why fraternal twins run in families. However, only women ovulate. So, the mother's genes control this and the fathers don't.
Most of our DNA determines that we are human, rather than determining how we are different from any other person. So it is not so surprising that the DNA of any two human beings is 99.9 percent identical.
If one egg is fertilised by two sperm, it results in three sets of chromosomes, rather than the standard two - one from the mother and two from the father. And, according to researchers, three sets of chromosomes are "typically incompatible with life and embryos do not usually survive".
If twins are a boy and a girl, clearly they are fraternal twins, as they do not have the same DNA. A boy has XY chromosomes and a girl has XX chromosomes. Girl-boy twins occur when one X egg is fertilized with an X sperm, and a Y sperm fertilizes the other X egg.
Occasionally, two sperm are known to fertilize a single egg; this 'double fertilization' is thought to happen in about 1% of human conceptions. An embryo created this way doesn't usually survive, but a few cases are known to have made it — these children are chimaeras of cells with X and Y chromosomes.
All human beings are 99.9 percent identical in their genetic makeup. Differences in the remaining 0.1 percent hold important clues about the causes of diseases.
Factors that increase the chance of twins include: consuming high amounts of dairy foods, being over the age of 30, and conceiving while breastfeeding. Many fertility drugs including Clomid, Gonal-F, and Follistim also increase the odds of a twin pregnancy.
Older women generally have a higher chance of conceiving twins. A 35 year old woman is about 4 times more likely to have fraternal twins than a 15 year old! That is because they are experiencing some hormonal changes as they near menopause. This could encourage their body to release more than one egg during ovulation.
Do Twins Skip Generations? Many people believe twins skip a generation, but that's just a myth. The idea that twins skip generations likely comes from the fact that the genetic factors contributing to twins only come from the gestational parent's side.
Monoamniotic-monochorionic Twins
These types of twins share a chorion, placenta, and an amniotic sac. This is the rarest type of twin, and it means a riskier pregnancy as the babies can get tangled in their own umbilical cords.
Dizygotic (DZ) twins, also called fraternal twins, occur when two egg cells are each fertilized by a different sperm cell in the same menstrual cycle. DZ twins are about twice as common as MZ twins, and they are much more likely to run in families.
What's the rarest blood type? AB negative is the rarest of the eight main blood types - just 1% of our donors have it.
"Twins married to twins who both have babies at the same time." Since identical twins share the same DNA, the children of two pairs of identical twins are legally cousins, but genetically more similar to siblings.
But you may be left wondering: Can twins have different fathers? The answer is yes, but only in cases in which they're fraternal, as identical twins form from a single egg/sperm combination and thus cannot have different fathers.
In rare cases, fraternal twins can be born from two different fathers in a phenomenon called heteropaternal superfecundation. Although uncommon, rare cases have been documented where a woman is pregnant by two different men at the same time.
The short answer is that while there are plenty of stories out there about twins who claim to have read each other's minds and predicted when the other was in danger, Nancy Segal, PhD, director of the Twin Studies Center, at California State University, Fullerton, says that scientific research doesn't support the idea.
Twin DNA testing can be used to confirm if two individuals are identical or non-identical (fraternal) twins. Should a twin need an organ or tissue transplant, an identical twin would be an optimal donor in most instances.