You should not take zoledronic acid if you are pregnant, breastfeeding, have severe kidney problems, or have low blood calcium (hypocalcemia); also avoid it if allergic to bisphosphonates, planning major dental surgery, or have certain eye/jaw issues, as it requires careful monitoring for kidney function, heart issues, and potential bone complications like osteonecrosis of the jaw (ONJ), with risks increased by smoking, steroids, or cancer treatments. Mayo Clinic +6
Mild diarrhoea that is self-limited has been reported with oral non-aminobisphosphonates but not with oral or intravenous aminobisphosphonates. We report a case of acute watery diarrhoea leading to severe hypotension and hyponatremia following ZA infusion.
Some people who take this medication have severe bone, joint, or muscle pain. This medication may also increase your risk for jaw problems or a broken thigh bone. Tell your care team right away if you have severe pain in your jaw, bones, joints, or muscles.
changes to your heartbeat. allergic reaction that can cause a rash, shortness of breath, redness or swelling of the face and dizziness - some allergic reactions can be life threatening, alert your nurse or doctor if notice any of these symptoms.
Side effects for all the bisphosphonates (alendronate, ibandronate, risedronate and zoledronic acid) may include bone, joint or muscle pain. Side effects of the oral tablets may include nausea, difficulty swallowing, heartburn, irritation of the esophagus (tube connecting the throat to the stomach) and gastric ulcer.
As with all medicines, some people may have side effects when they receive this treatment. Some of the side effects are flu-like symptoms including a temperature, headache and general aches and pains. These symptoms are usually mild and occur within the first three days following zoledronate treatment.
Common side effects
Because of their rarity and/or long latency, some adverse effects that have been associated with the use of bisphosphonates (including severe musculoskeletal pain, esophageal cancer, ocular inflammation, ONJ, oversuppression of bone turnover, and subtrochanteric femoral fractures) require health and dental care ...
Two major drug types to avoid or use with extreme caution in kidney disease are Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) like ibuprofen (Advil, Motrin) and naproxen (Aleve) for reducing blood flow to the kidneys, and certain antibiotics, such as aminoglycosides (like gentamicin) and some antivirals, which can directly harm kidney tissue. Always consult your doctor before taking any new medication, as many over-the-counter products and prescriptions can negatively impact kidney function.
Rheumatoid arthritis and its treatment with corticosteroids can increase an individual's chance of developing a low bone mineral state such as osteopenia or osteoporosis. Screening tests to identify poor bone mineralization are important along with treatment with medications, if indicated.
Treatment with ALN and ZOL is characterized by an important “tail effect”. Thus, after five years of optimal adherence, a treatment discontinuation might be planned in low-moderate risk patients, but the treatment holiday should rarely exceed 1–2 years with ALN and ZOL, respectively.
People with ONJ may experience pain, soft tissue swelling and drainage in the mouth, and an exposed jawbone for eight weeks or longer. Other possible signs are bad breath, loose teeth, and signs of infection of the gums.
Zoledronic acid reduces the activity of the cells that break down the bone (osteoclasts). This can help reduce pain and strengthen the bone. For primary breast cancer, it can reduce the risk of cancer spreading to the bones. Zoledronic acid also reduces the amount of calcium that is lost from the bones.
Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving the medicine. This medicine may cause hypocalcemia (low calcium in the blood). Low blood calcium must be corrected before you receive this medicine.
Osteoporosis may also be the initial sign of bowel disease in otherwise asymptomatic patients, who then may be referred to a gastroenterologist for further evaluation and management.
as corticosteroids (e.g., dexamethasone, prednisone), phosphate supplements, vitamin D, calcitonin, and diuretics such as furosemide (LASIX®) may interact with zoledronic acid. Tell your doctor if you are taking these or any other drugs as you may need extra blood tests or your dose may need to be changed.
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Extreme, on-going tiredness, together with a lack of energy, is often called fatigue. There are lots of reasons why you may experience fatigue with CKD. If your kidneys are not working well, toxins (waste products) build up in your blood and this can make you feel tired and weak.
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Nitrogen-containing bisphosphonates (NBPs) are associated with a reduced risk of Alzheimer's disease and related dementia. NBPs resulted in an absolute risk reduction of 0.007, 0.018, and 0.021 at 1, 3, and 5 years, respectively.
Weight-bearing aerobic activities
Examples include walking, dancing, low-impact aerobics, elliptical training machines, stair climbing and gardening. These types of exercise work directly on bones in the legs, hips and lower spine to slow bone loss. They also improve blood flow and are good for the heart.
In general, bisphosphonates like Boniva and Fosamax are well-tolerated. The most common side effects are mild and GI-related, like indigestion, nausea, and diarrhea or constipation.
Based on these findings we have something called as Rule of 2. If a patient consumed 20mg/day or more Cortisone or its equivalent, for a duration of 2 weeks or more, within 2 years then the dosage of the steroid medication should be doubled preoperatively.
How long is the immune system compromised after steroid injection? The immune system may be compromised shortly after a steroid injection, typically lasting a few days to a week. However, this can vary depending on factors such as the type and dosage of the steroid medication and individual health conditions.
Steroids are the medications most likely to cause skin thinning. Millions of people depend on steroids to treat a wide range of medical conditions. While they can be life saving, steroids can also cause a wide range of side effects. For example, steroids stop the body from making collagen.